Mukherjee Cardiovascular Innovations Lab
The Mukherjee Cardiovascular Innovations Lab harnesses multimodality imaging techniques to refine risk prediction of adverse clinical outcomes in autoimmune and rheumatologic diseases.
Research Advanced Multimodality Cardiovascular Imaging
The Mukherjee Cardiovascular Innovations Lab is dedicated to advancing precision cardiovascular medicine through innovative applications of multimodality imaging, computational analytics, and translational cardiovascular research.
Our work focuses on defining the mechanisms of cardiac and pulmonary vascular remodeling across a spectrum of cardiopulmonary diseases, with particular expertise in pulmonary vascular disease, right heart adaptation, systemic sclerosis, and inflammatory cardiovascular disorders. By integrating advanced echocardiography, cardiac magnetic resonance imaging, hemodynamic phenotyping, machine learning, and outcomes research, we seek to identify early markers of disease, refine risk stratification, and uncover novel pathways of cardiopulmonary dysfunction.
Through collaboration across clinical, imaging, and basic science disciplines, our goal is to translate advanced cardiovascular phenotyping into improved diagnosis, earlier intervention, and more personalized treatment strategies for patients with complex cardiovascular disease.
Principal Investigator Dr. Monica Mukherjee, M.D., M.P.H., FAHA, FACC, FASE
Dr. Monica Mukherjee is a Professor of Medicine in the Division of Cardiology at the Johns Hopkins University School of Medicine. She serves as Associate Director of the Johns Hopkins Echocardiography Program, Medical Director of the Echocardiography Laboratory at Johns Hopkins Bayview Medical Center, Director of Echocardiographic Research, and Program Director of the Advanced Echocardiography and Multimodality Cardiovascular Imaging Fellowship.
Dr. Mukherjee is an internationally recognized leader in multimodality cardiovascular imaging with expertise in right heart adaptation, pulmonary vascular disease, pulmonary hypertension, connective tissue disease associated cardiovascular complications, and cardiopulmonary hemodynamics. Her research integrates advanced echocardiography, cardiac magnetic resonance imaging, invasive hemodynamic phenotyping, machine learning, and population-based approaches to improve early disease detection, risk stratification, and precision cardiovascular medicine.
Dr. Mukherjee leads a multidisciplinary research program focused on understanding mechanisms of right heart dysfunction and cardiopulmonary vascular disease. Her work has contributed to the development of novel imaging biomarkers, advanced phenotyping strategies, and contemporary approaches to risk prediction in pulmonary vascular disease and systemic sclerosis.
Dr. Mukherjee currently serves in numerous national leadership roles, including membership on the American Society of Echocardiography Board of Directors, leadership positions within the American Heart Association, American College of Cardiology, Pulmonary Vascular Research Institute, and Chair of the American Society of Echocardiography Writing Group for the 2025 Guidelines for Echocardiographic Assessment of the Right Heart in Pulmonary Hypertension. She also serves on the editorial boards of Circulation, Journal of the American Society of Echocardiography, Journal of the American Heart Association and Circulation: Cardiovascular Imaging, and is Associate Editor of Echo Research and Practice.
Dr. Mukherjee graduated summa cum laude from the University of Florida with dual degrees in Behavioral Neuroscience and Psychology. She earned her Doctor of Medicine from The George Washington University School of Medicine and Health Sciences, completed Internal Medicine residency training at Drexel University College of Medicine, and subsequently completed fellowship training in Cardiovascular Disease at The George Washington University. She also earned a Master of Public Health from the Johns Hopkins Bloomberg School of Public Health, where she received the Dean's Scholarship Award for academic excellence.
Her research program is supported by the National Institutes of Health, the Department of Defense, and the National Scleroderma Foundation, with a focus on advancing innovative imaging approaches to improve outcomes for patients with cardiopulmonary and systemic inflammatory diseases.
Research Team
Anna Zaeske, B.S./M.S.
Senior Research Program Coordinator, Echocardiography
Anna Zaeske is a passionate researcher looking to further our knowledge of health and disease and aiming to become an established physician scientist. She graduated from Johns Hopkins University, receiving both Bachelor and Master of Science degrees in Molecular and Cellular Biology. During her degree program, she worked in Dr. Kyle Cunningham’s laboratory studying pathogenic yeast genetics and the microbiome. Now in the Mukherjee Lab, she assists various projects involving advanced imaging technologies and scleroderma risk-prediction, aiming to advance screening and treatment of cardiopulmonary disease. Outside of academia, Anna enjoys running and lifting, hiking, baking, and reading.
Ahmad Daoud, MBBS
Postdoctoral Fellow
Ahmad Daoud is currently a postdoctoral fellow and a medical graduate aiming to become a physician-scientist specializing in cardiovascular diseases. He graduated with honors from medical school in Saudi Arabia before moving to the United Kingdom, where he obtained a master's degree in Cardiovascular Research. He also worked as a clinical fellow in Cardiology at Guy’s and St Thomas’ hospital. His research focuses on echocardiography, specifically utilizing advanced conventional and speckle-based strain analysis alongside innovative biostatistical methods to identify systemic sclerosis patients at risk for adverse clinical outcomes. In his spare time, he enjoys soccer, billiards, and cooking.
Rayyan Islam, MBBS
Postdoctoral Fellow
Rayyan is a postdoctoral fellow aiming to become a physician-researcher in cardiology. He graduated with triple distinctions from the Imperial College School of Medicine in the United Kingdom, where he won numerous awards for teaching and leadership having led his Students’ Union. Building on time spent there contributing to work on AI-ECGs and a keen interest in tech and machine learning, his primary research interests involve utilizing deep learning with ECGs to identify patients at risk for cardiac manifestations of scleroderma. Outside of medicine, he’s an active runner and gym-goer, an avid reader, and a fan of both types of football, following Chelsea F.C. in his native London, and the Seattle Seahawks, where much of his family live and through which he was introduced to the US.
Hoda Mombeini, M.D.
Postdoctoral Fellow
Hoda Mombeini is a postdoctoral research fellow with a robust background in both clinical practice and research in cardiology. Following medical school, she specialized in cardiovascular disease and completed an echocardiography fellowship at Rajaie Heart Center in Iran. Hoda has held positions as an attending cardiologist at Ahvaz University and Tehran University of Medical Sciences in Iran, where she has actively led and contributed to numerous cardiology research projects. Her primary research interest is the role of advanced echocardiography in the early management of cardiovascular diseases, with a particular focus on left and right ventricular dysfunction and valvular heart disease. Outside of her professional life, she enjoys gym workouts, hiking, baking and singing.
Kaidong Wang, Ph.D.
Dr. Kaidong Wang is a Postdoctoral Fellow and Data Scientist in the Division of Cardiology at Johns Hopkins University School of Medicine. His research centers on the development of medical impedance devices and the application of multimodal machine learning in diagnostics. He earned his Ph.D. in Chemical Engineering from Tsinghua University in 2020. Following this, he completed a three-year postdoctoral fellowship at UCLA, where he worked on nanoengineered multichannel immunosensors and machine learning algorithms for acute thrombosis prediction. Currently, Dr. Wang’s work focuses on advancing multimodal machine learning for clinical data analysis and developing next-generation imaging techniques, including ultrasound and electrical impedance tomography, for cardiopulmonary monitoring. In his free time, he enjoys playing tennis and engaging in cardio workouts.
George Morcos, M.D.
Medical Resident
George grew up in Springfield, VA, and majored in biomedical engineering at the University of Virginia (Go Hoos!). After a gap year of research at the NIH, he attended medical school at George Washington University. There, he discovered his passion for medical imaging, medical education, and patient advocacy. He is currently an Osler resident in the Barker firm. In the Mukherjee lab, George's research focuses on the diagnostic performance of right ventricular parameters in detecting pulmonary hypertension. In his free time, you can find him spending time with family and friends, keeping up with the NFL, working out, visiting a national park, or exploring Baltimore’s diverse food scene.
Anagh Astavans, B.S.
Medical Student
Anagh Astavans is a 3rd year medical student at Johns Hopkins School of Medicine. Originally from Maryland, he graduated Summa Cum Laude from University of Maryland College Park in 2024 where he majored in Physiology and Neurobiology. During college he was deeply involved in a vaccine development lab where he studied HIV and Marburg viruses. Since starting medical school, Anagh has taken the lead on numerous clinical research projects in the realms of orthopaedic surgery and cardiology. In the Mukherjee Lab, he is involved in a number of echocardiographic projects focused on scleroderma patients. Outside of school, Anagh enjoys playing tennis, ping-pong, and doing origami.
Vivek Jani, B.S./M.S.
Medical Student
Vivek Jani is an M.D./Ph.D. candidate at the Johns Hopkins University School of Medicine with extensive expertise in translational research, harnessing advanced imaging techniques and machine learning methods in patients with heart failure and pulmonary vascular disease. Vivek completed his B.S./M.S. in biomedical engineering at the University of California, San Diego. Vivek received the prestigious AHA Samuel A. Levine Clinical Investigation Award in 2024 under Dr. Mukherjee's mentorship. He is also the recipient of the NIH/NHLBI F30 grant and the AHA Pre-Doctoral Fellowship. In the Mukherjee Research Lab, Vivek’s research focuses on multiparametric clinical phenotyping of systemic sclerosis patients with HFpEF, a project that earned him the National Scleroderma Foundation Dr. Arnold Postlethwaite Pre-Doctoral Summer Fellowship in 2022. Outside of his academic pursuits, Vivek enjoys exercising, traveling, and hiking.
Arindam Bagga
Undergraduate Student Researcher
Arindam Bagga is a junior at the Johns Hopkins University. He is currently studying Public Health and has an interest in cardiovascular epidemiology. His research in the Mukherjee lab is studying mortality trends and disparities that occur in different cardiovascular diseases, specially identifying sociodemographic factors and looking at ways to explain and reduce these disparities. He is also involved in studying echocardiographic features in patients with systemic sclerosis who have pulmonary hypertension alongside heart failure with preserved ejection fraction. Outside the lab, Arindam loves to be outdoors, watch movies, and play sports.
Mark Naddour
Undergraduate Student Researcher
Mark Naddour is an undergraduate studying Public Health at the Johns Hopkins University on the pre-med track. His work in the Mukherjee Lab currently explores the relationship between dysphagia and several multimorbidity clusters. He is interested in the impact of dysphagia on cardiovascular conditions, especially in populations who are at a higher risk of these diseases, like scleroderma patients. Mark plans to go to medical school with an interest in becoming an interventional cardiologist one day. In his free time, he enjoys weightlifting, playing video games, and traveling.
Ammar Mandviwalla
Undergraduate Student Researcher
Ammar Mandviwalla is an undergraduate at the Johns Hopkins University studying Molecular and Cellular Biology on the pre-medical track. In the Mukherjee Lab, he is exploring the relationship between dysphagia and cardiovascular disease, and clinical outcomes in high-risk patient populations. His interests include cardiovascular and pulmonary manifestations of systemic disease and how comorbidities impact hospitalization and disease severity. Ammar plans to pursue medical school with an interest in surgery. In his free time, he enjoys traveling, strength training, and hiking.
Lab Alumni
James Flynn, M.D.
Now: Medical Resident at the UCSF Internal Medicine Residency Program
Abhi Gami, M.D.
Now: Cardiovascular Disease Fellow at University of Pennsylvania
Garrett Goldin, B.S./M.S.
Now: Medical Student at Hackensack Meridian School of Medicine
Lea Goren, M.D.
Now: Medical Resident at the Osler Internal Medicine Residency, Johns Hopkins University
Brigitte Kazzi, M.D.
Now: Clinical Fellow at Brigham and Women’s Hospital, Harvard University
Ethan Knight, M.D.
Now: Medical Resident at JH Osler Internal Medicine
Katherine Lang, M.D.
Now: Cardiovascular Medicine Fellow at Cleveland Clinic
Jim Lu, M.D.
Now: Medical Resident at Brigham and Women’s Hospital, Harvard University
Ryan Osgueritchian, M.D.
Now: Internal Medicine Resident at JHB
Selected Publications
Echocardiographic Parameters and Risk Prediction in Pulmonary Arterial Hypertension: Insights From the Redefining Pulmonary Hypertension Through Pulmonary Vascular Disease Phenomics Network
Mukherjee M*, Jani VP, Osgueritchian R, Mombeini H, Abidov A, Beck G, Erzurum S, Franz RP, Hassoun PM, Hemnes AR, Hill NS, Horn EM, Kim J, Kwon D, Larive AB, Leary PJ, Leopold JA, Mathai SC, Mehra R, Park MM, Rosenzweig, Tang WH, Jellis CL, Rischard FR, Badagliacca R and the PVDOMICS Study Group. Echocardiographic Parameters Enhance Risk Prediction Scores in Pulmonary Arterial Hypertension: Insights from the PVDOMICS Network. CHEST. Chest. 2025 Apr 11:S0012-3692(25)00431-3. doi: 10.1016/j.chest.2025.04.007. PMID: 40222714
Refining Risk Prediction in Systemic Sclerosis-Associated Pulmonary Arterial Hypertension
Osgueritchian R, Jani VP, Mombeini H, Gami A, Goldin G, Hsu S, Hummers LK, Wigley FM, Lammi MR, Ambale-Venkatesh, B, Hassoun PM, Shah AA, Mathai SC, Mukherjee M.* Refining Risk Prediction in Systemic Sclerosis Associated Pulmonary Arterial Hypertension. J Am Soc Echocardiogr. 2025 Jul 29:S0894-7317(25)00406-7. doi: 10.1016/j.echo.2025.07.013. PMID: 40744380
Defining Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Vascular Disease from the PVDOMICS Study
Mukherjee M*, Mathai SC, Jellis C, Freed BH, Yanek LR, Agoglia H, Simpson CE, Brittain EL, Tang WH, Park MM, Hemnes AR, Rosenzweig EM, Rischard FR, Frantz RP, Hassoun PM, Beck G, Hill NS, Erzurum S, Thomas JD, Kwon D, Leopold JA, Horn EM, Kim J and the PVDOMICS Study Group. Echocardiographic Degrees of Right Heart Size and Function in Pulmonary Hypertension from the PVDOMICS Study. Circ Cardiovasc Imaging. 2024 Oct;17(10):e017074. doi: 10.1161/circimaging.124.017074. Epub 2024 Oct 15. PMID: 39691460
Prognostic Value of Echocardiographic Coupling Metrics in Systemic Sclerosis-Associated Pulmonary Vascular Disease
Gami A, Jani VP, Mombeini H, Osgueritchian R, Cubero Salazar IM, Kauffman M, Simpson CE, Damico RL, Kolb TM, Shah AA, Mathai SC, Tedford RJ, Hsu S, Hassoun PM, Mukherjee M.* Prognostic Value of Echocardiographic Coupling Metrics in Systemic Sclerosis-Associated Pulmonary Vascular Disease. J Am Soc Echocardiogr. 2024 Oct 1:S0894-7317(24)00468-1. doi: 10.1016/j.echo.2024.09.010. PMID: 39362283
Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography
Writing Chair Monica Mukherjee, Co-Chair Lawrence Rudski, Writing Group: Addetia K, Afilalo J, D’Alto M, Freed BH, Friend LB, Gargani L, Grapsa J, Hassoun PM, Hua L, Kim J, Mercurio V, Saggar R, Vonk-Noordegraaf A. Guidelines for the Echocardiographic Assessment of the Right Heart in Adults and Special Considerations in Pulmonary Hypertension: Recommendations from the American Society of Echocardiography. J Am Soc Echocardiogr. 2025 Mar;38(3):141-186. doi: 10.1016/j.echo.2025.01.006. PMID: 40044341
Optimal Method for Assessing Right Ventricular to Pulmonary Arterial Coupling in Older Healthy Adults: The Multi-Ethnic Study of Atherosclerosis
Jani VP, Strom JB, Gami A, Beussink-Nelson L, Patel R, Michos ED, Shah SJ, Freed BH, Mukherjee M. Optimal Method for Assessing Right Ventricular to Pulmonary Arterial Coupling in Older Healthy Adults: The Multi-Ethnic Study of Atherosclerosis. Am J Cardiol. 2024 Jul 1;222:11-19. doi: 10.1016/j.amjcard.2024.03.043. Epub 2024 Apr 19. PMID: 38643925; PMCID: PMC11175998.
Normative Values of Echocardiographic Chamber Size and Function in Older Healthy Adults: The Multi-Ethnic Study of Atherosclerosis
Mukherjee M, Strom JB, Afilalo J, Hu M, Beussink-Nelson L, Kim J, Addetia K, Bertoni AG, Gottdiener JS, Michos ED, Gardin JM, Shah SJ, Freed BH. Normative Values of Echocardiographic Chamber Size and Function in Older Healthy Adults: The Multi-Ethnic Study of Atherosclerosis. Circ
Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement
Weber BN, Paik JJ, Aghayev A, Klein AL, Mavrogeni SI, Yu PB, Mukherjee M. Novel Imaging Approaches to Cardiac Manifestations of Systemic Inflammatory Diseases: JACC Scientific Statement. J Am Coll Cardiol. 2023 Nov 28;82(22):2128-2151. doi: 10.1016/j.jacc.2023.09.819. PMID: 37993205; PMCID: PMC11238243.
Characteristics of Right Ventricular to Pulmonary Arterial Coupling and Association With Functional Status Among Older Aged Adults from the Multi-Ethnic Study of Atherosclerosis
Mukherjee M*, Ogunmoroti O, Kapoor K, Beussink-Nelson L, Min K, Freed BH, Hays AG, Shah SJ, Michos ED. Characteristics of Right Ventricular to Pulmonary Arterial Coupling and Association with Functional Status Among Older Aged Adults in the Multi-Ethnic Study of Atherosclerosis. Am J Cardiol. 2023 Apr 15;196:41-51. doi: 10.1016/j.amjcard.2023.03.016. PMID:
Defining minimal detectable difference in echocardiographic measures of right ventricular function in systemic sclerosis
Mukherjee M, Mercurio V, Balasubramanian A, Shah AA, Hsu S, Simpson CE, Damico R, Kolb TM, Hassoun PM, Mathai SC. Reliability, Repeatability, and Reproducibility of Echocardiographic Measures of Right Ventricular Function in Systemic Sclerosis. Arthritis Res Ther. 2022 Jun 18;24(1):146. doi: 10.1186/s13075-022-02835-5. PMID: 35717399
Contact Information
600 N. Wolfe St., Carnegie 536,
Baltimore, MD 21287
Phone: 410-502-2319
Fax: 410-367-2151
Research Funding
The Mukherjee Cardiovascular Innovations Lab receives funding from the NIH/NHLBI, the Department of Defense and the National Scleroderma Foundation.