Adamo Cardiac Immunology Lab
The Adamo Cardiac Immunology Lab seeks a deeper understanding of the relationship between the immune system and cardiac function, with specific attention to B-cell myocardial interactions.
Research Team
Maryam Ebadi Fard Azar, M.D.
Maryam Azar completed her M.D. at the Iran University of Medical Sciences, where she also worked as a research assistant during and after medical training. She served as an ER physician in Mehregan Psychiatric Hospital in Tehran, Iran, before coming to Johns Hopkins as a post-doctoral research fellow in the Department of Pulmonary and Critical Care Medicine in Dale Needham’s Lab, where she investigated improvement of outcomes in ICU patients after intubation. Then, as a research fellow in the Department of Neuropathology with Tong Li and Philip Wong, she studied Tau pathology in Alzheimer's disease. Now with the Adamo Lab, Maryam is investigating the immune links to pediatric cardiomyopathies, and plans to pursue her clinical licensure in the United States.
Beyond the lab and the clinic, Maryam enjoys painting, reading philosophy, and the vibrant social life of the Washington, D.C., and Baltimore areas. Maryam is a polyglot, speaking Farsi, Turkish and Azerbaijani fluently, and learning Yiddish.
Kevin Bermea, M.D., M.Sc.
Charles Cohen, Ph.D.
Oby Ebenebe, Ph.D., M.Sc.
Oby is a post-doctoral fellow in the Adamo Lab, with a previous fellowship at Johns Hopkins School of Public Health with Mark Kohr in the department of Environmental Health and Engineering. Born in Nigeria, raised in England, she graduated from the University of Leicester (UK) with a BSc in Biological Sciences: Physiology with Pharmacology and from Kings College London with an M.Sc. in Human and Applied Physiology. Oby completed her Ph.D. in Physiology at the University of Otago (New Zealand) training with Jeff Erickson. Her research interest is in understanding the physiological differences of the cardiovascular system between the sexes and how these differences influence disease progression.
Qiao Huang, B.S., B.M.
Qiao Huang graduated with honors from The Johns Hopkins University Krieger School of Arts and Sciences, earning a Bachelor of Science degree in Molecular and Cellular Biology. During his undergraduate education, Qiao served as a research assistant at the Biology of Healthy Aging (BOHA) program at The Johns Hopkins Medicine Bayview Medical Center. Under the mentorship of Dr. Jeremy Walston, Dr. Peter Abadir, and Dr. Qinchuan Wang, he focused on investigating the roles of the kynurenine-NAD biosynthesis pathway and ox-CAMKII in inflammation and aging.
In May 2024, Qiao joined the Adamo Cardiac Immunology Lab, where he is investigating the molecular mechanisms underlying cardiomyopathies and exploring the clinical implications of these discoveries in basic science. His current research centers around the role of B cells in mediating the heart's response to pressure overload.
Qiao also holds a Bachelor of Music degree in Jazz Saxophone Performance from the Peabody Institute Conservatory at The Johns Hopkins University. He continues to nurture his passion for music in his pastime, balancing his scientific endeavors with his artistic pursuits.
Jana Lovell, M.D.
Sylvie Rousseau
Helen Song, B.S.
Yiran (Helen) Song is currently pursuing a master’s degree in biomedical engineering at Johns Hopkins. She received her bachelor’s degree in Bioengineering: Biotechnology from the University of California San Diego. She is interested in cardiac physiology and inflammation. Helen’s undergraduate research was dedicated to identifying extracellular RNA as biomarkers for Alzheimer’s Disease from plasma and cerebrospinal fluid. She also worked on designing a device to facilitate the imaging of small-scale blood vessels under a multiphoton microscope. Helen joined the Adamo Lab in February 2024, and her work focuses on characterizing B cell non-depleting antibodies.
Outside of work, Helen enjoys ice skating, dancing, and exploring Baltimore with her friends.
Former Lab Members
Aashik Bhalodia, B.S.
Aashik Bhalodia studied molecular and cellular biology and classics at Johns Hopkins University. He has worked in basic science research labs, as well as hospital and outpatient facilities, and he approaches research from an interdisciplinary perspective. Aashik joined the Adamo Lab in June 2022 and moved on to pursue his Ph.D. at Yale University.
Marcelle Dina Zita, Ph.D.
Marcelle Dina Zita was a post-doctoral research fellow in the Adamo Lab. Born and raised in Yaoundé, Cameroon, Marcelle moved to the U.S. to pursue a bachelor of science degree at the University of Arkansas at Little Rock. She then completed a Ph.D. in microbiology and immunology under the mentorship of Dr. Karl Boehme at the University of Arkansas for Medical Sciences, investigating mechanisms of reovirus-induced cardiac pathology. With the Adamo Lab, her work focused on developing a viral-induced murine model for pediatric cardiac pathology. She went on to work in patent law.
Fabiana Pani, M.D.
Fabiana Pani is a physician-scientist born and raised in Cagliari, Sardinia, Italy, She completed her M.D. and post-graduate training in endocrinology at the Universities of Pisa and Cagliari, focusing on autoimmune diseases and endocrinopathies. Fabiana completed a first post-doctoral fellowship at Johns Hopkins with Patrizio Caturegli, studying autoimmune thyroiditis. With the Adamo Lab, she applied her knowledge of autoimmune disease to the emerging field of immunotherapy. In 2022, Fabiana followed her passion for patient care and assumed a clinician-researcher role at Gustave Roussy University Hospital in Paris, France.
Selected Publications
- Serum Proteomic Analysis of Peripartum Cardiomyopathy Reveals Distinctive Dysregulation of Inflammatory and Cholesterol Metabolism Pathways.
Lovell, J.P., Bermea, K.C., Yu, J., Rousseau, S.R., Cohen, C.D., Bhalodia, A., Dina Zita, Head, R.D., Blumenthal, R.S., Alharethi, R., Damp, J., Boehmer, J., Alexis, J., McNamara, D.M., Sharma, G., Adamo, L. (2023). JACC: Heart Failure. doi: 10.1016/j.jchf.2023.05.031 - Myocardial Immune Cells: The Basis of Cardiac Immunology.
Cohen, C.D., Rousseau, S.R., Bermea, K.C., Bhalodia, A., Lovell, J.P., Dina Zita, M., Čiháková, D., Adamo, L. (2023). Journal of Immunology, 210 (9): 1198–1207. doi: 10.4049/jimmunol.2200924 - The role of B cells in cardiomyopathy and heart failure.
Bermea, K. C., Bhalodia, A., Huff, A., Rousseau, S. T., & Adamo, L. (2022). Current Cardiology Reports, 24(8), 935–946. doi: 10.1007/s11886-022-01722-4 - Flow cytometry-based quantification and analysis of Myocardial B-cells.
Bermea, K. C., Rousseau, S. T., & Adamo, L. (2022). Journal of Visualized Experiments, (186). doi: 10.3791/64344
- The human myocardium harbors a population of naive B-cells with a distinctive gene expression signature conserved across species.
Bermea, K. C., Kostelecky, N., Rousseau, S. T., Lin, C.-Y., & Adamo, L. (2022). Frontiers in Immunology, 13. doi: 10.3389/fimmu.2022.973211 - B cells modulate the expression of MHC-II on cardiac CCR2 macrophages. Rocha-Resende C, Pani F, Adamo L. J Mol Cell Cardiol. 2021 May 8;157:98-103. doi: 10.1016/j.yjmcc.2021.05.003. Epub ahead of print. PMID: 33971183.
- The Emerging Role of B Lymphocytes in Cardiovascular Disease.
Adamo L, Rocha-Resende C, Mann DL.Annu Rev Immunol. 2020 Apr 26;38:99-121. doi: 10.1146/annurev-immunol-042617-053104.PMID: 32340574
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Reappraising the role of inflammation in heart failure.
Adamo L, Rocha-Resende C, Prabhu SD, Mann DL.Nat Rev Cardiol. 2020 May;17(5):269-285. doi: 10.1038/s41569-019-0315-x. Epub 2020 Jan 22.PMID: 31969688 Review. -
Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart.
Adamo L, Rocha-Resende C, Lin CY, Evans S, Williams J, Dun H, Li W, Mpoy C, Andhey PS, Rogers BE, Lavine K, Kreisel D, Artyomov M, Randolph GJ, Mann DL.JCI Insight. 2020 Feb 13;5(3):e134700. doi: 10.1172/jci.insight.134700.PMID: 31945014 -
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
Adamo L, Yu J, Rocha-Resende C, Javaheri A, Head RD, Mann DL. J Am Coll Cardiol. 2020 Oct 27;76(17):1982-1994. doi: 10.1016/j.jacc.2020.08.061. PMID: 33092734; PMCID: PMC7584807.
Mission Statement
The Adamo Lab is a research team that pursues the advancement of biomedical knowledge for the benefit of humanity.
We recognize excellence, innovation, integrity, teamwork, equity, and respect among our core values.
Each team member supports the personal and professional goals of all other team members, within the framework of our mission and core values, understanding that the success of the individual is the success of the whole team.