Adamo Cardiac Immunology Lab
The Adamo Cardiac Immunology Lab seeks a deeper understanding of the relationship between the immune system and cardiac function, with specific attention to B-cell myocardial interactions.
Research Team
Charles Cohen, Ph.D.
Oby Ebenebe-Kasonde, Ph.D., M.Sc.
Oby is a Research Associate and former post-doctoral fellow in the Adamo Lab, with a previous fellowship at Johns Hopkins School of Public Health with Mark Kohr in the department of Environmental Health and Engineering. Born in Nigeria, raised in England, she graduated from the University of Leicester (UK) with a BSc in Biological Sciences: Physiology with Pharmacology and from Kings College London with an M.Sc. in Human and Applied Physiology. Oby completed her Ph.D. in Physiology at the University of Otago (New Zealand) training with Jeff Erickson. Her research interest is in understanding the physiological differences of the cardiovascular system between the sexes and how these differences influence disease progression.
Harriet He, B.S.
Kshipra Keole, B.S.
Kshipra Keole is currently pursuing a master's degree in biotechnology from Johns Hopkins University. She received her bachelor's degree in biotechnology from SASTRA University, India. Her research interests center around cardiovascular diseases and related conditions, with a particular focus on developing therapeutic interventions to address these challenges. Kshipra’s undergraduate research work was on ameliorating ischemic reperfusion injury in the heart with a special focus on analyzing the damaged heart’s mitochondrial bioenergetics. She also studied the effect of diesel particulate matter on the heart and the development of the hypertrophy phenotype in mice with neurogenic hypertension. Kshipra joined the Adamo lab in September 2024. Outside of work, Kshipra enjoys reading books, quizzing and watching movies and tv shows.
Sylvie Rousseau, B.A.
Helen Song, B.S., M.S.
Yiran (Helen) Song is currently pursuing a PhD degree in biomedical engineering at Johns Hopkins. She completed her master's in biomedical engineering at Johns Hopkins, and received her bachelor’s degree in Bioengineering: Biotechnology from the University of California San Diego. She is interested in cardiac physiology and inflammation. Helen’s undergraduate research was dedicated to identifying extracellular RNA as biomarkers for Alzheimer’s Disease from plasma and cerebrospinal fluid. She also worked on designing a device to facilitate the imaging of small-scale blood vessels under a multiphoton microscope. Helen joined the Adamo Lab in February 2024, and her work focuses on characterizing B cell non-depleting antibodies.
Outside of work, Helen enjoys ice skating, dancing, and exploring Baltimore with her friends.
Former Lab Members
Kevin Bermea, M.D., M.Sc.
Aashik Bhalodia, B.S.
Aashik Bhalodia studied molecular and cellular biology and classics at Johns Hopkins University. He has worked in basic science research labs, as well as hospital and outpatient facilities, and he approaches research from an interdisciplinary perspective. Aashik joined the Adamo Lab in June 2022 and moved on to pursue his Ph.D. at Yale University.
Marcelle Dina Zita, Ph.D.
Marcelle Dina Zita was a post-doctoral research fellow in the Adamo Lab. Born and raised in Yaoundé, Cameroon, Marcelle moved to the U.S. to pursue a bachelor of science degree at the University of Arkansas at Little Rock. She then completed a Ph.D. in microbiology and immunology under the mentorship of Dr. Karl Boehme at the University of Arkansas for Medical Sciences, investigating mechanisms of reovirus-induced cardiac pathology. With the Adamo Lab, her work focused on developing a viral-induced murine model for pediatric cardiac pathology. She went on to work in patent law.
Maryam Ebadi Fard Azar, M.D.
Qiao Huang, B.S., B.M.
Qiao also holds a Bachelor of Music degree in Jazz Saxophone Performance from the Peabody Institute Conservatory at The Johns Hopkins University. He continues to nurture his passion for music, balancing his scientific endeavors with his artistic pursuits.
Jana Lovell, M.D.
Jana Lovell was a cardiology clinical fellow who joined the
Adamo Lab as a post-doctoral fellow. She received her M.D. degree from Johns
Hopkins University School of Medicine. She went on to complete her internal medicine
training in the Osler Residency Program at Hopkins. After finishing her first two
clinical years of cardiology training at Hopkins, she joined the Adamo Lab as a
T32 research fellow to combine her interests in heart failure and immunology.
Following her research fellowship, completed additional training in
advanced heart failure and transplant.
Fabiana Pani, M.D.
Fabiana Pani is a physician-scientist born and raised in Cagliari, Sardinia, Italy, She completed her M.D. and post-graduate training in endocrinology at the Universities of Pisa and Cagliari, focusing on autoimmune diseases and endocrinopathies. Fabiana completed a first post-doctoral fellowship at Johns Hopkins with Patrizio Caturegli, studying autoimmune thyroiditis. With the Adamo Lab, she applied her knowledge of autoimmune disease to the emerging field of immunotherapy. In 2022, Fabiana followed her passion for patient care and assumed a clinician-researcher role at Gustave Roussy University Hospital in Paris, France.
Selected Publications
- Serum Proteomic Analysis of Peripartum Cardiomyopathy Reveals Distinctive Dysregulation of Inflammatory and Cholesterol Metabolism Pathways.
Lovell, J.P., Bermea, K.C., Yu, J., Rousseau, S.R., Cohen, C.D., Bhalodia, A., Dina Zita, Head, R.D., Blumenthal, R.S., Alharethi, R., Damp, J., Boehmer, J., Alexis, J., McNamara, D.M., Sharma, G., Adamo, L. (2023). JACC: Heart Failure. doi: 10.1016/j.jchf.2023.05.031 - Myocardial Immune Cells: The Basis of Cardiac Immunology.
Cohen, C.D., Rousseau, S.R., Bermea, K.C., Bhalodia, A., Lovell, J.P., Dina Zita, M., Čiháková, D., Adamo, L. (2023). Journal of Immunology, 210 (9): 1198–1207. doi: 10.4049/jimmunol.2200924 - The role of B cells in cardiomyopathy and heart failure.
Bermea, K. C., Bhalodia, A., Huff, A., Rousseau, S. T., & Adamo, L. (2022). Current Cardiology Reports, 24(8), 935–946. doi: 10.1007/s11886-022-01722-4 - Flow cytometry-based quantification and analysis of Myocardial B-cells.
Bermea, K. C., Rousseau, S. T., & Adamo, L. (2022). Journal of Visualized Experiments, (186). doi: 10.3791/64344
- The human myocardium harbors a population of naive B-cells with a distinctive gene expression signature conserved across species.
Bermea, K. C., Kostelecky, N., Rousseau, S. T., Lin, C.-Y., & Adamo, L. (2022). Frontiers in Immunology, 13. doi: 10.3389/fimmu.2022.973211 - B cells modulate the expression of MHC-II on cardiac CCR2 macrophages. Rocha-Resende C, Pani F, Adamo L. J Mol Cell Cardiol. 2021 May 8;157:98-103. doi: 10.1016/j.yjmcc.2021.05.003. Epub ahead of print. PMID: 33971183.
- The Emerging Role of B Lymphocytes in Cardiovascular Disease.
Adamo L, Rocha-Resende C, Mann DL.Annu Rev Immunol. 2020 Apr 26;38:99-121. doi: 10.1146/annurev-immunol-042617-053104.PMID: 32340574
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Reappraising the role of inflammation in heart failure.
Adamo L, Rocha-Resende C, Prabhu SD, Mann DL.Nat Rev Cardiol. 2020 May;17(5):269-285. doi: 10.1038/s41569-019-0315-x. Epub 2020 Jan 22.PMID: 31969688 Review. -
Myocardial B cells are a subset of circulating lymphocytes with delayed transit through the heart.
Adamo L, Rocha-Resende C, Lin CY, Evans S, Williams J, Dun H, Li W, Mpoy C, Andhey PS, Rogers BE, Lavine K, Kreisel D, Artyomov M, Randolph GJ, Mann DL.JCI Insight. 2020 Feb 13;5(3):e134700. doi: 10.1172/jci.insight.134700.PMID: 31945014 -
Proteomic Signatures of Heart Failure in Relation to Left Ventricular Ejection Fraction
Adamo L, Yu J, Rocha-Resende C, Javaheri A, Head RD, Mann DL. J Am Coll Cardiol. 2020 Oct 27;76(17):1982-1994. doi: 10.1016/j.jacc.2020.08.061. PMID: 33092734; PMCID: PMC7584807.
Mission Statement
The Adamo Lab is a research team that pursues the advancement of biomedical knowledge for the benefit of humanity.
We recognize excellence, innovation, integrity, teamwork, equity, and respect among our core values.
Each team member supports the personal and professional goals of all other team members, within the framework of our mission and core values, understanding that the success of the individual is the success of the whole team.