The Sidney Kimmel Comprehensive Cancer Center

Johns Hopkins Kimmel Cancer Center Researchers at

AACR 2024 Annual Meeting

 

Below is a list of posters presented by Johns Hopkins Kimmel Cancer Center researchers and collaborators and co-authors from other research institutions at the annual meeting of the American Association for Cancer Research, April 5 – 10, 2024, San Diego, CA.

For the full abstracts and author affiliations, please visit the AACR Annual Meeting website below and search by Abstract #.

Posters

 

·      Abstract #165 - PVRL2 Upregulation by Tumor-Associated Macrophages Confers a Regulatory Phenotype and is Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer

Authors: K. Murakami, H. Ando, M. Doucet, D. Ding, W. Huang, S. Ganguly

 

·      Abstract #170 - Targeting of Macrophage PI3Kγ in Prostate Cancer Using Eganelisib (IPI-549) Reprograms Immune-Suppressive Infiltrating Macrophages to Enhance Anti-Tumor Immune Responses and Promote Immunologically Mediated Tumor Growth

Authors: K. M. Adusei, T. R. Nirschl, A. J. Lee, F. Shen, X. Wang, M. Praharaj, J. Alvarez, I. Gross, K. A. Lombardo, T. L. Lotan, J. A. Varner, J. C. Zarif

 

·      Abstract #273 - Extrinsic Photoaging vs Intrinsic Aging in Dermal Fibroblasts: Its Impact on the Microenvironment and Melanoma Progression

Authors: V. Wang, Y. Chhabra, L. Hueser, A. Weeraratna

 

·      Abstract #515 - Endocycling Cancer Cells Undergo Multiple S Phases While Repressing Myc Activity

Authors: M. A. Loycano, K. J. Pienta, S. R. Amend

 

·      Abstract #527- Cancer Cells in The Resistant, Endocycling Cell State Exhibit Centrosome Amplification

Authors: M. Purkerson, S. Amend, K. J. Pienta

 

·      Abstract #540 - Identification of Therapy Resistance Mediating Extracellular Vesicles in Single-Cell Level Via a Novel Microfluidic Co-Culture Device Development

Authors: C.-J. Kim, S. Amend, K. Pienta

 

·      Abstract #970 - Liquid Biopsy-Informed Precision Oncology Clinical Trial to Evaluate the Utility of Ctdna Comprehensive Genomic Profiling

Authors: M. Fatteh, M. Conroy, T. Wanchoo, S. Shiqing Teh, J. Wehr, A. Balan, R. Karchin, E. Verner, K. Karaindrou, R. Xian, C. Gocke, M.-T. Lin, P. Fitzpatrick, C. L. Hann, J. C. Murray, V. K. Lam, J. L. Feliciano, J. R. Brahmer, K. A. Marrone, P. M. Forde, K. Fiallos, D. Petry, T. Botsis, M. Sausen, t. Molecular Tumor Board Investigators, J. Canzoniero, J. Tao, V. Anagnostou

 

·      Abstract #988 – Genome-wide Repeat Landscapes in Cancer and Cell-free DNA

Authors: A. Annapragada, N. Niknafs, J. R. White, D. C. Bruhm, C. Cherry, J. E. Medina, V. Adleff, C. Hruban, D. Mathios, Z. H. Foda, J. Phallen, R. B. Scharpf, V. E. Velculescu

 

 

·      Abstract #1096 - Enhancing Effector Function in T Cell Adoptive Cell Therapy in Murine Models of Pediatric Sarcomas

Authors: J. P. Sanchez, E. Davila, B. H. Ladle

 

·      Abstract #1159 - Machine Learning Integrating Spatial Omics Uncovers Humoral Immunity Patterns in Intratumoral Tertiary Lymphoid Structures in Pancreatic Cancer Pathologic Responders
Authors: D. N. Sidiropoulos, S. M. Shin, A. Girgis, D. H. Shu, J. Montagne, A. Deshpande, J. A. I. Johnson, L. Dequiedt, V. Jacobs, A. Ogurtsova, G. Mo, X. Yuan, G. Stein-O’Brien, M. Yarchoan, Q. Zhu, A. Kiemen, E. M. Jaffee, L. Zheng, W. Ho, R. Anders, E. J. Fertig, L. T. Kagohara

 

·      Abstract #1170 - An Off-the-shelf Vaccine Activates Mutant KRAS-specific T Cells in Patients with Resected Pancreatic Cancer
Authors: A. L. Huff, A. Girgis, S. D. Haldar, E. Davis-Marcisak, T. Heumann, G. Longway, L. Andaloori, A. Hernandez, M. F. Konig, B. Mog, L. Danilova, L. T. Kagohara, J. M. Nauroth, A. M. Thomas, E. J. Fertig, W. Ho, E. M. Jaffee, N. Azad, N. Zaidi

 

·      Abstract #1184 - Combination Pembrolizumab and Radiotherapy Induces Anti-Tumor Immune Responses in Immunologically-Cold Non-Small Cell Lung Cancer

Authors: J. Huang, W. S. M. Theelen, Z. Belcaid, M. Najjar, C. Cherry, A. Balan, J. R. White, N. Niknafs, J. Wehr, M. van den Heuvel, R. Karchin, P. Baas, V. E. Velculescu, V. Anagnostou

 

·      Abstract #1245 - The Histone Methyltransferase KMT2D Mediates Subtype-specific Transcriptional Regulation and Therapeutic Response in Prostate Cancer
Authors: S. Kittane, E. Ladewig, T. Li, J. Love, A. Arruabarrena-Aristorena, X. Guo, M. Sallaku, L. Garcia-Martinez, R. Blawski, J. Carmona Sanz, C. Simpkins, W. Chen, B. Vokshi, P. Zhao, N. Kelkar, L. Baldino, I. Kalemi, P. Castel, E. Cocco, L. Morey, C. Sawyers, H. Ji, M. Scaltriti, A. Battle, C. Leslie, W. Karthaus, E. Toska

 

·      Abstract #1289 – Disparities in Health Care Utilization and Access among Female Cancer Survivors in Maryland

Authors: A. E. Connor, M. Jin, K. Visvanathan

 

·      Abstract #1323 - Anti-B7-H3 Chimeric Antigen Receptor NK Cells Suppress the Growth of Atypical Teratoid/Rhabdoid Tumor Orthotopic Xenografts

Authors: J. Choe, S. Chakravarti, N. Holl, R. Rahnama, M. Zinsky, D. G. Jones, S. Vorri, A. Modi, E. H. Raabe, C. L. Bonifant

 

·      Abstract #1327 - Affinity Tuning Anti-CD123 Chimeric Antigen Receptor Natural Killer Cell Therapy to Treat Acute Myeloid Leukemia

Authors: M. Kizerwetter, H. Yang, R. Rahnama, C. Bonifant, J. Spangler

 

·      Abstract# 1374 - Targeting CD47/Sirpɑ Axis in Urologic Cancer Triggers Enhanced Phagocytosis of Tumor Cell and Induces Tumor Growth Inhibition

Authors: F. Shen, M. Praharaj, A. J. Lee, T. R. Nirschl, X. Wang

 

·      Abstract #1384 - Highly Metastatic PDAC Adopts Mesenchymal Morphology and Spatially Coordinates Endothelial Cells with Macrophages
Authors: N. E. Gross, S. Charmsaz, J. W. Lee, C.-C. Huang, A.G. Hernandez, S.M. Shin, E. M. Coyne, C. Cannon, X. Yuan, L. D. Wood, E. M. Jaffee, W. Ho

 

·      Abstract #1463 - Characterizing Inflammation-Induced Epigenetic and Transcriptomic Alterations Driving NSCLC Using Lung Organoid Models

Authors: N. Wang, K. Lombardo, R. Padaki, R.-W. Chiu Yen, M. V. Brock, L. Cope, H. Easwaran, S. B. Baylin, M. Vaz

 

·      Abstract #1577 – Cancer-Associated Fibroblast – Tumor Cell Crosstalk Enhances Epithelial to Mesenchymal Transition and Promotes a Classical to Basal Switch in Human Pancreatic Ductal Adenocarcinoma

Authors: S. Guinn, B. Perez, J. Patel, J. Lee, D. Zabransky, W. J. Ho, E. J. Fertig, E. Kartalia, J. Tandurella, R. Burkhart, J. W. Zimmerman, E. Jaffee

 

·      Abstract #1851 - Comprehensive Multi-Level Proteomics Characterization of Gastric Cancer

Authors: Y. Wang, Clinical Proteomic Tumor Analysis Consortium (CPTAC)

 

·      Abstract #2082 – Identification of Nonsense-Mediated Decay Inhibitors That Alter the Tumor Immune Landscape

Authors: Ashley L. Cook, Surojit Sur, Laura Dobbyn, Evangeline Watson, Joshua D. Cohen, Plair Ptak, Bum Seok Lee, Suman Paul, Emily Hsiue, Maria Popoli, Bert Vogelstein, Nickolas Papadopoulos, Chetan Bettegowda, Kathy Gabrielson, Shibin Zhou, Kenneth Kinzler

 

·      Abstract #2312 - Integrating Spatial Multi-Omics Data with Spatial Quantitative Pharmacology (Spqsp) Model to Simulate Human Neoadjuvant Immunotherapy Clinical Trial of Hepatocellular Carcinoma

Authors: Shuming Zhang, Atul Deshpande, Babita K. Verma, Hanwen Wang, Haoyang Mi, Long Yuan, Won Jin Ho, Elizabeth M. Jaffee, Qingfeng Zhu, Robert A. Anders, Mark Yarchoan, Luciane T. Kagohara, Elana J. Fertig, Aleksander S. Pope

 

·      Abstract #2422 - Liquid Biopsy Approaches for Monitoring Metastatic Pancreatic Cancer in Immunotherapy Treated Patients

Authors: C. A. Hruban, I. Chen, D. C. Bruhm, S. Koul, J. Yao, S. Theile, K. Boyapati, N. A. Vulpescu, A. Annapragada, L. Ferreira, S. Cristiano, Z. H. Foda, V. Adleff, J. Johansen, J. Phallen, R. B. Scharpf, V. E. Velculescu

 

·      Abstract #2476 - Electroporation-Mediated Novel Albumin-Fused Flt3L DNA Delivery Promotes Cdc1-Associated Anticancer Immunity

Authors: M.-H. Hu, T.-C. Wu, C.-F. Hung

 

·      Abstract #2631 - HMGA1 Chromatin Regulators Drive Immune Evasion in Myeloproliferative Neoplasms by Repressing Gene Networks Involved in Antigen Presentation

Authors: A.-A. Supreme, L. M. Resar, J. Kim, B. West, M. Antopia, H. Woo, K. Reddy, J.-H. Kim, L. Cope, J. Spivak, A. Moliterno

 

·      Abstract #3043- MYC Activation and PTEN Loss Synergistically Activate Proliferation in a Mouse Model of Lethal Prostate Cancer

Authors: M. Rubenstein, T. Jones, J. Hicks, A. Rege, Q. Zheng, C. Gomes-Alexandre, G. Hubbard, S. Yegnasubramanian, C. Bieberich, A. DeMarzo

 

·      Abstract #3572 - Role of the Gut Microbiome in Androgen Production and Prostate Cancer Treatment Resistance

Authors: A. I. Cruz Lebron, P. A. Balbuena-Almodóvar, L. Mummert, S. Ernst, M. Markowski, M. Rudek, J. Ridlon, K. S. Sfanos

 

·      Abstract #3666 - Multi-Cancer Early Detection Using Metrics of DNA Methylation Based Epigenetic Instability

Authors: S.J. Thursby, Z. Jin, S. B. Baylin, M. Brock, T. Pisanic II, H. Easwaran

 

·      Abstract #3766 - Utilizing Whole-Transcriptome Digital Spatial Profiling for Glioblastoma Clinical Biomarker Discovery

Authors: A. Luo, K. Casella, S. Sharma, E. Baraban, C.-H. Lucas, E. Shenderov

 

·      Abstract #3846 - The Obesity Paradox in Immune Checkpoint Blockade: A Pan-Tumor Analysis

Authors: S. L. Alden, S. Charmsaz, M. Brancati, H. L. Li, A. Warner, K. Munjal, K. Howe, S. Mitchell, E. Griffin, M. Nakazawa, H.-L. Tsai, L. Danilova, C. Thoburn, J. Gizzi, A. Hernandez, N. E. Gross, E. M. Coyne, S. M. Shin, J. Durham, M. F. Konig, B. J. Christmas, E. J. Lipson, J. Naidoo, L. C. Cappelli, A. Pabani, Y. Ged, M. Baretti, J. R. Brahmer, J. Hoffman-Censits, T. Y. Seiwert, S. Bansal, L. Tang, E. Jaffee, G. Chandler, R. Mohindra, W. Ho, M. Yarchoan, C. Kao

 

·      Abstract # 3978 – B-cell Activating Factor (BAFF) Enhances Anti-tumor Immunity

Authors: K. Aziz, K. Munjal, K. Howe, M. Yarchoan

 

·      Abstract #4339 - Chromatin Landscapes of Colorectal Cancer Development and cfDNA Fragmentation

Authors: N. A. Vulpescu, Z. H. Foda, P. H. A. Wisse, J. E. Medina, V. Adleff, R. J. A. Fijneman, R. B. Scharpf, G. A. Meijer, B. Carvalho, V. E. Velculescu

 

·      Abstract #4896 -  A High Throughput Method of Identifying Cells with Increased Genomic Content Across Diverse Cancer Tissues

Authors: S. Priyadarsini Nair, K. J. Pienta, S. R. Amend

 

·      Abstract #5109 - Novel Acylfulvene LP184 Shows Single Agent and Combinatorial Efficacy with PARP Inhibitors in Atypical Teratoid Rhabdoid Tumors

Authors: Abigail Tindall, Hyuk J. Kwon, Istabraq Musa, Tyler Findlay, Su Chan Lee, Charles Eberhart, Eric Raabe

 

·      Abstract #5306 - PTPN22 Targeting Partners with 41BB/OX40 Costimulation to Overcome Anti-PD1 Resistance in Pancreatic Ductal Adenocarcinoma
Authors: S. Charmsaz, N. E. Gross, J. W. Lee, J. Lin, A. G. Hernandez, E. M. Coyne, S.M. Shin, C. Cannon, X. Yuan, Z.-Y. Zhang, E. M. Jaffee, W. Ho

 

·      Abstract #5323 - Inflammation Drives Lineage Plasticity and a Club Cell-Like Phenotype in Prostate Epithelial Cells

Authors: M. Hess, H. Song, J. Hicks, L. Mummert, A. De Marzo, F. W. Huang, K. Sfanos

 

·      Abstract #5461 - Antecedent STING Agonist Therapy Improves Tumor Response to Chemotherapy in Murine Models of Osteosarcoma

Authors: E. E. Resch, E. Kulp, M. Doucet, A. Recho, B. H. Ladle

 

·      Abstract # 5993 - Temporal dynamics of ferroptosis vulnerability in a resistant cancer cell state

Authors: L. Loftus, K. Pienta, S. Amend

 

·      Abstract #6086 - Early Detection of Ovarian Cancer Using Cell-Free DNA Fragmentomes and Protein Biomarkers

Authors: J.E. Medina, A. V. Annapragada, P. Lof, S. Short, A. Bartolomucci, R. Dua, D. Mathios, M. Noë, Z. H. Foda, D. C. Bruhm, E. Jung, J. Canzoniero, N. Niknafs, S. Cristiano, V. Adleff, H. Symecko, D. van de Broek, L. Sokoll, S. B. Baylin, M. F. Press, D. Slamon, G. Konecny, S. Domchek, R. Drapkin, J. Phallen, R. B. Scharpf, C. Lok, V. E. Velculescu

 

·      Abstract #6092 - Three-Dimensional Multi-Omic Analysis of Early Invasion of Human Pancreatic Ductal Adenocarcinoma from IPMN

Authors: S. Datta, S. M. Shin, J. Kanacharoen, M. J. Pflüger, K. Hirose, A. Forjaz, S. Graham, P.-H. Wu, R. H. Hruban, D. Wirtz, W. J. Ho, A. L. Kiemen, L. D. Wood

 

·      Abstract #6212 – A Differential Ligand-receptor Network Interference Method to Identify Alterations in Communication Between Myeloid Cells and CD8 T Cells in Response to PancVAX Neo-epitope Peptide Vaccine, Anti-CTLA-4 and Anti-PD-1 Antibodies in a Murine Model of Pancreatic Ductal Adenocarcinoma

Authors: Jacob T. Mitchell, Atul Deshpande, Amanda L. Huff, Chris Cherry, Sushma Nagaraj, Kavita Krishnan, Dmitrijs Lvovs, Jennifer H. Elisseeff, Elizabeth M. Jaffee, Neeha Zaidi, Elana J. Fertig

 

 

·      Abstract #6472 - Response to PARP Inhibitors in Patients with Breast Cancer Metastatic to the Central Nervous System
Authors: S. Lee, R. Bansal, M. E. Hughes, A. E. D. Van Swearingen, H. N. Moore, D. O. Kamson, S. Sahebjam, G. Kirkner, A. Gorfinkel, S. Sammons, N. U. Lin, C. Anders, C. A. Santa-Maria

 

·      Abstract #6498 - MEK Inhibitor Mirdametinib Suppresses MAP Kinase Pathway Activity and Inhibits Tumor Growth in Atypical Teratoid/Rhabdoid Tumors

Authors: Y. Deng, K. Malebranche, T. Findlay, A. Geethadevi, C. Eberhart, J. Rubens, E. Raabe

 

·      Abstract #6689 - Modulation of Maits by the Tumor Microbiome in Anti-PD1 Treated Cancers

Authors: P. Birla, L. Yang, C. Sears, F. Shaikh, D. Pardoll, F. Housseau

 

·      Abstract #6819 – Exploring the Impact of IDH1-Mutations on Anti-Tumor Immunity in Intrahepatic Cholangiocarcinoma

Authors: E. Kartalia, J. M. Leatherman, J. W. Lee, K. Yoshima, D. J. Zabransky, M. Yarchoan

 

·      Abstract #6844 – Discovery of a Novel Sialic Acid O-acetyltransferase in colon tissue

Authors: B. Lee, A. Cook, M. Zeineldin, S. Sur, L. Dobbyn, M. Popoli, S. Khalili, B. Vogelstein, N. Papadopoulos, S. Zhou, C. Bettegowda, P. Buckhaults, T. Larman, K. Gabrielson, K. W. Kinzler, N. Wyhs

 

·      Abstract #6986 - Oncogenic CARD11 Enhances Marginal Zone B Cell Survival by Potentiating the Non-Canonical NF-Κb Pathway

Authors: Anushka Ghosh, Joel Pomerantz

 

·      Abstract #7154 - Ivospemin/Doxorubicin Combination Modulates Polyamine Metabolism to Improve Survival in Murine Ovarian Cancer Models

Authors: Cassandra E. Holbert, Jackson R. Foley, Ashley C. Nwafor, Ting-Ann Liu, Elizabeth Bruckheimer, Jennifer K. Simpson, Tracy Murray Stewart, Robert A. Casero

 

·      Abstract #7243 - Crispr-Cas9 Genetic Targeting of Metastatic Pancreatic Cancer

Authors: K. Bowland, J. Lai, S. K. Teh, A. Bennett, A. Skaist, Y. Zhang, E. Thompson, R. H. Hruban, N. J. Roberts, R. Karchin, C. A. Iacobuzio-Donahue, J. R. Eshleman

 

·      Abstract #7430 - Development and Demonstration of a User-Friendly Application to Explore Single-Cell Atlas for Prostate Cancer (Pca) and Analyze Newly Generated Single-Cell and Spatial Pca Datasets

Authors: S. Sharma, E. Shenderov

 

·      Abstract #7467 - Multi-Omics Analysis Reveals High Chronic Inflammation in African Americans Compared to Native African Men with Prostate Cancer

Authors: I. Elhussin, E. Baraban, T. L. Lotan, C. Handy Marshall, E. Antonarakis, M. J. Campbell, M. Davis, M. Dixon, I. Kim, S. Ambs, R. Kittles, A. B. Murphy, C. Yates

 

·      Abstract #7525 - Investigating B7-H3 as a Checkpoint and Antibody Drug Conjugate Target Across Prostate Cancer Variants- Both Androgen Receptor Dependent and Independent

Authors: N. Mundhara, S. Sharma, E. Tekoglu, E. G. Baraban, N. A. Lack, E. Shenderov

 

·      Abstract #7555 - Selective Inhibition of the Corest Complex as a Novel Therapeutic Target of Atypical Teratoid Rhabdoid Tumors

Authors: Anupa Geethadevi, Marianne Collard, Tyler Findlay, Yiming Deng, Robert Fisher, Nikhil Vaidya, Charles Eberhart, Philip A. Cole, Rhoda Alani, Jeffrey Rubens, Eric Raabe