Services & Instrumentation

Bayview CPAL

Laboratory benches are equipped with materials to process and prepare samples for bioanalytical testing.
The CPAL has capacity for short and long-term freezer storage. The biorepository is equipped with remote and real-time temperature monitoring.
Liquid chromatographic-mass spectrometric (LC-MS) instruments can facilitate the selective and sensitive quantification of target biomolecules.
Liquid chromatographic-mass spectrometric (LC-MS) instruments can facilitate the selective and sensitive quantification or identification of biomolecules.
Analytical areas are customized for management and extraction of target molecules from numerous biological matrices.

The CPAL is equipped with biosafety cabinets for the management and processing of biological samples.
The CPAL biological suite is equipped with instrumentation for cell isolation from tissue, biopsy incubation, and cell counting.
The CPAL also has expertise and capacity to perform targeted genetic analysis to better understand PK-PD relationships.

Matrix	Collection Device	Analytes
Plasma	K2EDTA	Cabotegravir, Dapivirine, Efavirenz, Emtricitabine, Ethambutol, Etravirine, IQP-0528, Isoniazid, Maraviroc, Medroxyprogesteroneacetate, Moxifloxacin, PA-824, Pyrazinamide, Raltegravir, Rifampin, Rifapentine, Desacetyl-rifapentine, Rilpivirine, Tenofovir,Tenofovir alafenamide fumarate
PBMCs	CPT	Tenofovir-diphosphate
Dried Blood Spots	Whatman	Rifapentine, Desacetyl-rifapentine
Tissue	Cervical, vaginal, colonic	Cabotegravir, Dapivirine, Emtricitabine, Ethambutol, Etravirine, Isoniazid, Maraviroc, Moxifloxacin, PA-824, Pyrazinamide, Raltegravir, Rifapentine, Rifampin, Rilpivirine, Tenofovir, Tenofovir-diphosphate
Breast Milk	Whole	Dapivirine, Emtricitabine, Tenofovir
Cerebrospinal Fluid	N/A	Efavirenz, Tenofovir, Emtricitabine
Cervicovaginal Fluid	Dacron Swab	Dapivirine, Emtricitabine, Maraviroc, Tenofovir, Tenofovir disoproxil fumarate
Cervicovaginal Fluid	Merocal Sponge	Dapivirine, Emtricitabine, Maraviroc, Tenofovir
Cervicovaginal Fluid	Tear Strip	Dapivirine, Maraviroc
Cervicovaginal Lavage	N/A	Dapivirine, Emtricitabine, Maraviroc, Tenofovir, Tenofovir disoproxil fumarate
Rectal Fluid	Weck Cel Sponge	Emtricitabine, Tenofovir
Rectal Fluid	Merocel Sponge	Emtricitabine, Maraviroc, Tenofovir
Rectal Fluid	Dacron Swab	Emtricitabine, Dapivirine, Maraviroc, Tenofovir, Rilpivirine

Assays are validated in accordance with the FDA, Guidance for Industry, Bioanalytical Method Validation.

The CPAL is an integral part of the Pharmacology Cores of the HIV Prevention Trials Network (HPTN) and the Microbicide Trials Network (MTN).