Our mission is to create a unique service & research center that focuses on providing highest level surgical and microsurgical expertise for advanced physiologic in vivo modeling. Johns Hopkins University, in combination with the research environment available in Baltimore and the greater Washington D.C. area, presents an ideal environment and opportunity to initiate this goal. The Johns Hopkins Center for Advanced Physiologic Modeling (CAPM) is the first, catalytic step towards this goal. Specifically, we aim to:

• Enhance Johns Hopkins’ translational research impact. 
• Enable clinically translatable research by providing access to advanced, reliable, fit-for-purpose in vivo models for academic researchers and industry partners.
• Facilitate multidisciplinary, and trans-disciplinary collaboration within JHU and in tune with JHU Tech Ventures in order to close the translational gap 
• Provide education and microsurgical training for research staff and surgical residents locally, nationally, and globally in partnership with Johns Hopkins International
• Perform research to enhance technological capacities in areas relevant to the Core mission.
• Nerve repair and regeneration
  • Advanced microscopy
  • Quantitative strength assessment
  • Growth factor delivery

Compared to the surge in scientific innovation and new fields of science, realization of transformational scientific discoveries rarely materialize into FDA-approved drugs, devices or more rarely become commonly adopted by the medical community. A critical limiting factor for this “translational gap” is a lack of access to adequately designed and conducted, reliable preclinical animal models. The CAPM aims to leverage the extensive surgical and microsurgical skills and expertise within the Department of Plastic and Reconstructive Surgery as well as its unmatched record of establishing translational small and large animal models and make this widely available as a resource to the research community within Johns Hopkins and beyond. The center will also serve as a platform and translational hub that allows for integration of academia, industry, and small and startup businesses to facilitate cutting-edge research and to catalyze academic and entrepreneurial collaboration and partnerships in multiple areas including but not limited to drug and medical device development, regenerative medicine and tissue engineering, transplantation, as well as organ and tissue preservation.

Services Provided and Modeling Capabilities

Bioreactors

• Normothermic machine perfusion
• Organ and tissue reconditioning
• Immune engineering

Next Generation Tissue and Organ Preservation

• Nature-inspired cryoprotectants
• High subzero supercooling
• Ice-free vitrification
• Organ and tissue banking