Research
Medical physics research serves as a vital bridge between technological advancements and clinical practices. More details about the multifaceted roles of medical physicists can be found at the American Association of Physicists in Medicine.
Department of Radiology and Radiological Science
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- Quantitative multiple radionuclides simultaneous acquisition SPECT reconstruction
- SPECT Imaging of alpha emitters and development of CZT based Alpha-SPECT system
- Dynamic PET and tracer kinetic modeling for neurological diseases
- Imaging based dosimetry for radiopharmaceutical imaging and therapy
- Digital twin for nuclear medicine
- Deep learning-based methods for image registration, segmentation, and analysis
- Fully automated whole-body tumor quantification and prognosis of cancer on PET/CT
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- Optimize radiopharmaceutical therapy (RPT).
- RPT dose and response modeling.
- Alpha-emitter RPT (αRPT), in vivo RBE evaluation in collaboration with Radiation Oncology SARRP facility.
- Develop and evaluate agents for alpha-RPT to treat a variety of cancers (breast, liver/liver mets, melanoma).
- Monolayer and spheroid response to DNA repair modulators with α-emitters.
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- Imaging/dosimetry-driven clinical dose escalation trial of Y-90 microsphere therapy
- Treatment planning-based combination radiotherapy and αRPT for prostate cancer
- Treatment planning-based combination radiotherapy and radioiodine RPT for thyroid cancer
- Canine osteosarcoma αRPT trial
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- Quantitative imaging and image quality optimization to assess therapeutic response in prostate cancer patients with skeletal metastases.
- Quantitative SPECT imaging of therapeutic radionuclides, including Ac-225, Ra-223, Pb-212 and Th-227
- Pediatric nuclear medicine imaging optimization
- Image-guided intervention and advanced ultrasound imaging to develop ultrasound-guided solutions for a variety of medical conditions.
- Task-based diagnostic image quality evaluation.
- Spectral, photon-counting-detector-based CT
- Acute ischemic stroke imaging using dual-energy CT
- Motion estimation and compensation for cardiac CT
- Iterative image reconstruction methods and task-based image quality evaluation for x-ray CT.
- Helical cone-beam CT
- Interventional soft tissue perfusion using x-ray system.
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- Microscale dosimetry of alpha-emitters.
- RPT treatment and response simulations to translate preclinical model results towards human trial design optimization.
- NURBS phantom-based simulation of SPECT/CT imaging of nuclear medicine agents.
- NURBS phantom-based simulation of CT imaging for improved diagnosis of pancreatic cancer
- AI-based image reconstruction, quality assessment, response evaluation.
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- Ongoing development of patient-specific radiobiological dosimetry methods.
- Clinical trial evaluation of absorbed dose vs response.
- Uncertainty evaluation for radiopharmaceutical dosimetry chain.
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- Develop strategies that better communicate radiation doses and risks with patients and staff.
Department of Radiation Oncology and Molecular Radiation Sciences
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- Cone Beam CT
- MR Imaging
- Advanced Ultrasound
- Image-Guided Interventions
- Medical Image Computing and Analysis
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- Image Processing
- Automatic Treatment Planning
- Outcome Prediction
- Quality Assurance
- Natural Language Processing
- Vision Language Model
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- Brachytherapy automation
- Imaging and image-guidance techniques
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- Immuno-radiotherapy
- Nanotechnology
- FLASH Radiotherapy
- Spatially Fractionated Radiation Therapy (SFRT)
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- PreClinical Radiation Technology
- Radiation Response Modeling
- Radiobiological Imaging
- Radiobiological Optimization
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- Treatment Planning
- Imaging Techniques
- Motion Monitoring
- Quality Assurance
- Radiobiology and outcome modeling
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- Access to Cancer Care
- Cancer Prevention and Education
- Health Policy and Global Partnerships
- Cancer Research in low- and middle-income countries