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  • Dwight Bergles Laboratory

    The Bergles Laboratory studies synaptic physiology, with an emphasis on glutamate transporters and glial involvement in neuronal signaling. We are interested in understanding the mechanisms by which neurons and glial cells interact to support normal communication in the nervous system. The lab studies glutamate transport physiology and function. Because glutamate transporters play a critical role in glutamate homeostasis, understanding the transporters' function is relevant to numerous neurological ailments, including stroke, epilepsy, and neurodegenerative diseases like amyotrophic lateral sclerosis (ALS). Other research in the laboratory focuses on signaling between neurons and glial cells at synapses. Understanding how neurons and cells communicate, may lead to new approaches for stimulating re-myelination following injury or disease. Additional research in the lab examines how a unique form of glia-to-neuron signaling in the cochlea influences auditory system development, whether defects in cell communication lead to certain hereditary forms of hearing impairment, and if similar mechanisms are related to sound-induced tinnitus.
    Lab Website

    Principal Investigator

    Dwight E. Bergles, PhD

    Department

    Neuroscience

  • Veit Stuphorn Laboratory

    The Veit Stuphorn Laboratory studies the neurophysiological mechanisms that underlie decision making and self-control. We record the activity of single neurons in awake animals that are engaged in decision-making processes. This allows us to identify the types of signals that neurons in specific parts of the brain represent and the computations they carry out. We also study human subjects in the same tasks with the help of fMRI. These parallel experiments provide comparative information about decision processes in human and non-human primates.

    Principal Investigator

    Veit Stuphorn, PhD

    Department

    Neuroscience

  • Ted Dawson Laboratory

    The Ted Dawson Laboratory uses genetic, cell biological and biochemical approaches to explore the pathogenesis of Parkinson's disease (PD) and other neurologic disorders. We also investigate several discrete mechanisms involved in cell death, including the role of nitric oxide as an endogenous messenger, the function of poly (ADP-ribose) polymerase-1 and apoptosis inducing factor in cell death, and how endogenous cell survival mechanisms protect neurons from death.
    Lab Website

    Principal Investigator

    Ted M. Dawson, MD PhD

    Department

    Neurology