Research in the Hansoti Lab centers on the intersection of public health interventions for vulnerable populations and emergency department care. The lab employs implementation science methodologies, with a particular emphasis on mixed-methods research to design, develop, and evaluate innovative, evidence-based strategies that support socially vulnerable patients.

In South Africa, the team is pioneering strategies to enhance HIV prevention and intervention delivery within emergency departments, focusing on improving HIV service delivery for patients missed within the health system and delivering preventative care strategies to patients at high risk of HIV acquisition. These efforts are concentrated at Tygerberg Hospital and Gugulethu Clinic, in partnership with the Desmond Tutu HIV Foundation.

Domestically, the lab conducts research on opioid use disorder (OUD), specifically addressing post-discharge health system challenges related to linkage to care and retention for patients prescribed medications for opioid use disorder (MOUD). This includes addressing social determinants of health to strengthen HIV services for patients who present to the ED.

Additionally, Dr. Hansoti has a dedicated focus on surveillance strategies for high-consequence pathogens in emergency departments. She serves as the Principal Investigator for the Clinical Characterization Protocol for Severe Emerging Infections (CCPSEI) and manages cohorts for both COVID-19 and mpox, in collaboration with experts in public health, epidemiology, and infectious diseases from the Johns Hopkins School of Public Health.