The Maura McGuire Lab focuses on the improvement of quality and safety in ambulatory medicine through care management, point-of-care laboratory testing, and electronic health records and care delivery optimization. We also study the use of assessment and technology to augment learning in health care professionals and primary care physicians.

Our lab evaluates new medications and/or techniques for the treatment of drug use disorder by conducting human laboratory studies to sensitively assess drug effects, and randomized controlled trial evaluations of medications for clinical treatment outcomes. We also focus on the development of outcome measures that are sensitive and clinically relevant.

Research in the Meredith McCormack Lab deals primarily with pulmonary diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and the role of environmental exposures in lung diseases. We have researched the factors that contribute to inner-city asthma, with a focus on how particulate matter air pollution impacts pulmonary function. We are also part of the LIBERATE clinical study, which is focused on patients who experience difficulty breathing and have been diagnosed with severe emphysema. We also have a longstanding interest in the effects of race/ethnicity, poverty and urbanization on nutrition and food allergies.

A basic and translational science laboratory focused on diseases of platelets. We are interested in learning the physiologic mechanisms of platelet function, characterizing the genetic variants that can cause inherited platelet dysfunction, and developing therapeutics that can modulate platelet function to ameliorate human disease.

The Merkin Center's goal is to advance peripheral neuropathy research, deepen our understanding of these conditions and their causes and develop viable therapies. The center will tackle pressing research questions in peripheral neuropathy, with a particular focus on areas that impede the development of better diagnostic and therapeutic strategies.

Research in the Michael A. Rosen Lab primarily focuses on patient safety and simulation-based health care training and technology. Recent work provided examples of how human factors experts can collaborate with health care professionals and simulationists (experts in the design and implementation of simulation) to use contemporary simulation to improve health care delivery. Another recent study examined the anesthesia practice at two tertiary care hospitals in Sierra Leone, West Africa, where anesthesia is associated with high mortality rates. We identified gaps in the application of internationally recommended anesthesia practices at both hospitals, likely caused by lack of available resources.

The Michael B. Streiff Lab conducts clinical and laboratory research of thrombophilia associated with malignancy. We are interested in the application of novel coagulation assays to explore the pathogenesis of thrombosis and the development of strategies to enhance the clinical management of anti-thrombotic agents.

The Caterina lab is focused on dissecting mechanisms underlying acute and chronic pain sensation. We use a wide range of approaches, including mouse genetics, imaging, electrophysiology, behavior, cell culture, biochemistry and neuroanatomy to tease apart the molecular and cellular contributors to pathological pain sensation. A few of the current projects in the lab focus on defining the roles of specific subpopulations of neuronal and non-neuronal cells to pain sensation, defining the role of RNA binding proteins in the development and maintenance of neuropathic pain, and understanding how rare skin diseases known as palmoplantar keratodermas lead to severe pain in the hands and feet.

The Michael Goggins Lab performs basic, translational, and clinical research on pancreatic cancer.

The Michael Klag Lab focuses on the epidemiology and prevention of kidney disease, cardiovascular disease and hypertension. Our research determined that the U.S. was experiencing an epidemic of end-stage kidney disease, pinpointed the incidence of kidney disease and published scholarship on risk factors for kidney disease such as race, diabetes and socioeconomic status. Our Precursors Study has shown that serum cholesterol measured at age 22 years is a predictor for midlife cardiovascular disease, a finding that has influenced policy about cholesterol screening in young adults. We also research health behaviors that lead to hypertension and study how differences in these behaviors affect urban and non-urban populations.