Center for Sleep Research and Education

Mission

The Johns Hopkins Center for Interdisciplinary Sleep Research and Education (CISRE), is committed to education, training, coordination, and data management for research in sleep medicine. The CISRE serves the entire Hopkins community, as well as private and industry-based, national and international sleep research projects outside of Johns Hopkins.

CISRE Core Expertise

The CISRE has over 30 years of clinical sleep research experience. It facilitates the acquisition and analysis of sleep-related data including polysomnography, home sleep studies and actigraphy. It leverages the expertise and resources of sleep specialists across a range of medical disciplines, including pulmonary, neurology, psychiatry, endocrinology, pediatrics, otorhinolaryngology, and anesthesia. Investigators utilize the CISRE to address fundamental questions related to sleep. With the support from the CISRE, results of these studies are published in peer-reviewed papers.

CISRE Services

Sleep study acquisition:

CISRE is equipped with a 10-bed sleep research center and chronobiology suite. We can provide monitoring and interventions that are not included in standard clinical polysomnography, including sleep restriction/deprivation, fragmentation and collection of customized data channels.

Sleep scoring:

CISRE maintains an American Academy of Sleep Medicine-accredited scoring hub. The hub conducts regular Q/A feedback with inter-scorer reliability exercises. CISRE provides immediate access to sleep recordings and prompt study reports. A versatile information technology backbone accommodates both “in-lab” and mobile “home” sleep testing.

Sleep questionnaires:

CISRE has a repository of standardized sleep questionnaires integrated into REDCap.

Sleep data management:

CISRE provides comprehensive sleep data management services and is experienced in:

• Coordinating single and multicenter sleep-related clinical trials
• Generating sleep study reports, data queries, signal processing and breath-by-breath analysis
• Developing and maintaining REDCap databases, specialized software, and reporting systems
• Providing secure web-based data-transfer
• Archiving recordings in a HIPAA-compliant network with back-up and version control

CISRE Charge Master (FY 2024)

CISRE Infrastructure and Staffing

• CISRE staff and facilities are located on the Johns Hopkins Bayview Medical Center Campus
• The polysomnographic (PSG) lab utilizes a state-of-the-art 12,400 sq. foot sleep unit equipped with 10 beds for basics, intensive physiological and circadian experiments. The unit is located on the 4th floor of the Johns Hopkins Bayview campus 301 building. Polysomnographic recordings are obtained using EMBLA N7000 acquisition equipment for recording PSG data
• The CISRE is supported by dedicated registered sleep technologists who are licensed in the state of Maryland to perform polysomnographic recordings
• A data management core provides investigators and sponsors with immediate access to their sleep recordings, as well as prompt sleep study reports. This core provides customizable software and robust, secure mechanisms for transmission of sleep recordings to and from our scoring hub
• In-lab and/or mobile domiciliary polysomnographic testing capabilities to record, score, analyze and archive raw and summary sleep data
• Advanced IT infrastructure for capturing, analyzing, and archiving sleep data

CISRE-Supported Studies

• Wrist-mounted actigraphy monitors to track and characterize sleep patterns in Division I Hopkins athletes
• Wrist-mounted actigraphy monitors to determine whether sleep predicts relapse or remission in patients with psychiatric illness
• Evaluation of sleep disordered breathing in Peruvian highlanders
• Examining impacts of sleep apnea on overnight fat and glucose metabolism
• Evaluating effects of sleep and circadian rhythm on overnight metabolism
• Development of a prospective PSG data registry
• Service as a data coordinating center for multi-center sleep trials