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Psychiatry & Behavioral Sciences

Smith Lab

Publications

Select Research Publications

  1. Smith WW, Pei Z, Jiang H, Moore DJ, Liang Y, West AB, Dawson VL, Dawson TM, Ross CA. LRRK2: Interaction with parkin and mutation-induced neuronal degeneration. Proc Natl Acad Sci USA. 2005, 102 (51):18676-81.
  2. Smith WW, Norton DD, Gorospe M, Jiang H, Nemoto S, Holbrook NJ, Finkel T, Kusiak JW. Phosphorylation of p66Shc and forkhead proteins mediates Ab toxicity. J Cell Biol. 2005, 25;169(2):331-9.
  3. Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA. Kinase activity of mutant LRRK2 mediates neuronal toxicity. Nature Neurosci. 2006, 9(10):1231-3.
  4. Liu Z, Wang X, Yu Y, Li X, Wang T, Jiang H, Ren Q, Jiao Y, Sawa A, Moran T, Ross CA, Montell C, Smith WW. A Drosophila model for LRRK2-linked Parkinsonism. Proc Natl Acad Sci USA. 2008, 105(7): 2693-8.
  5. Li X, Tamashiro KL, Liu Z, Bello NT, Wang X, Aja S, Bi S, Ladenheim EE, Ross CA, Moran TH, Smith WW. A novel obesity model: Synphilin-1 induced hyperphagia and obesity in mice. Int J Obesity. 2012; 5(6): 864-73.
  6. Liu J, Li T, Yang D, Ma R, Moran TH, Smith WW. Synphilin-1 alters metabolic homeostasis: a novel Drosophila model for obesity. Int J Obesity. 2012; 36(12):1592.
  7. Li T, Yang D, Zhong S, Thomas JM, Xue F, Liu J, Kong L, Voulalas P, Hassan HE, Park JS, MacKerell AD Jr, Smith WW. Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson’s disease cell and mouse models. Hum Mol Genet. 2014: 23(23):6212-22.
  8. Liu J, Li T, Thomas JM, Pei Z, Jiang H, Engelender S, Ross CA, Smith WW. Synphilin-1 attenuates mutant LRRK2-induced neurodegeneration in Parkinson’s disease models. Hum Mol Genet. 2016. 25(4):672-80.
  9. Thomas JM, Li T, Yang W, Xue F, Fishman PS, Smith WW. 68 and FX2149 attenuate mutant LRRK2-R1441C-induced neural transport impairment. Front Aging Neurosci. 2017, 10;8:337.
  10. Arbez N, He X, Huang Y, Ren M, Liang Y, Nucifora FC Jr, Wang X, Pei Z, Tessarolo L, Smith WW, Ross CA. A new mouse model of LRRK2 gene-environment interaction for Parkinson’s Disease. Hum Mol Genet. 2020; 29(4):580-590.
  11. Wang X, Teng T, Zhang J, Guo G, He X, Pei Z, Liu Z, Liu C, Ross CA, Smith WW. TMEM230 mediates a PARP1-linked apoptosis. Front Aging Neurosci; 2020; 12:235.
  12. Li T, Liu J, Guo G, Ning B, Li X, Zhu G, Yang D, Moran TH, Smith WW. Synphilin-1 interacts with AMPK, and increases AMPK phosphorylation. Int J Mol Sci. 2020 Jun 18;21(12):4352.
  13. Li T, Ning B, Kong L, Dai B, He X, Thomas JM, Sawa A, Ross CA, Smith WW. A LRRK2 GTP binding inhibitor, 68 reduces LPS-induced signaling events and TNF-α release in human lymphoblast. Cells. 2021, 10(2):480.
  14. Liu J, Wang X, Ma R, Li T, Guo G, Ning B, Moran TH, Smith WW. AMPK signaling mediates synphilin-1-induced hyperphagia and obesity in Drosophila. J Cell Sci. 2021, 134(3):jcs247742.
  15. Wang X, Guo G, Zhang Z, Liu Z, Liu CF, Ross CA, Smith WW. Mutant TMEM230 induced neuro-degeneration and impaired axonal mitochondrial transport. Hum Mol Genet. 2021; 30(16):1535-1542.
  16. Lin L, Huang L, Huang S, Chen W, Huang H, Chi L, Su F, Liu X, Yuan K, Jiang Q, Li C, Smith WW, Fu Q, Pei Z. MSC-Derived Extracellular Vesicles Alleviate NLRP3/GSDMD-Mediated Neuroinflammation in Mouse Model of Sporadic Alzheimer's Disease. Mol Neurobiol. 2024 In press.
  17. H Huang, L Lin, T Wu, C Wu, L Zhou, G Li, F Su, F Liang, W Guo, W Chen, Q Jiang, Y Guan, X Li, P Xu, Y Zhang, WW Smith and Zhong Pei. Phosphorylation of AQP4 by LRRK2 R1441G impairs glymphatic clearance of IFNγ and aggravates dopaminergic neurodegeneration. npj Parkinson's Disease. 2024 In press.

 

Review Articles

  1. Smith WW, Gorospe M, Kusiak JW. Signaling mechanisms underlying Aβ toxicity: implications on neuronal loss in Alzheimer’s disease pathogenesis. CNS Neurol Disord Drug Targets. 2006; 5(3): 355-61.
  2. Li T, Yang D, Sushchky S, Liu Z, Smith WW. Models for LRRK2-Linked Parkinsonism. Parkinson’s Dis. 2011; 942412.
  3. Smith WW, Li T, Thomas J, Moran TH. From fat fruitfly to human obesity. Physiol Behav. 2014:136:15-21.
  4. Wang Y, Smith WW, Hao D, He B, Kong L. M1 and M2 macrophage polarization and potentially therapeutic naturally occurring compounds. Int Immunopharmacol. 2019; 70:459-466. Role: writing outline and revision.
  5. Liu Y, Dou H, Yan L, Yang X, He B, Kong L, Smith WW. The role of Rho GTPases substrates Rac and Cdc42 in osteoclastogenesis and relevant natural medicinal products study. Biosci Rep. 2020; 40(7): BSR20200407.
  6. Wang X, Liu Z, Whelan E, Liu C, Smith WW. Controversy of TMEM230 associated with Parkinson’s Disease. Neuroscience. 2020; 453:280-286.