Meet Our Experts

Expertise Matters

Our experts are uniquely positioned to make progress because much of the science that inspired precision medicine unfolded here. In 2008, Kimmel Cancer Center experts completed the genetic blueprint for pancreatic cancer, mapping out all the mutations in known human genes linked to cancer that make proteins that tell cells how to behave. The discovery uncovered an unexpected terrain of diversity in alterations from tumor to tumor. It explained why seemingly similar cancers often responded very differently to the same treatments. Still among the diversity were also some commonalities. Most of the mutations occurred in the same gene pathways, connected interactions that may conspire to promote cancer.

This was the launching point for precision medicine. Now, genetics are used to guide treatment and measure its effectiveness. Experts could drill down to the molecular level to look for alterations to target with drugs and determine if microscopic cancer cells, invisible in imaging, remained after surgery that could seed a recurrence without additional treatment.

With the genetic blueprint of pancreatic cancer complete, other re-searchers could begin to probe deeper and create a more complete picture of pancreatic cancer from origin to metastasis. This work expands opportunities to earlier detection and possibly, one day, prevention.

Early Detection

Precision medicine may also lead to earlier detection, before the cancer has spread. Our experts developed a blood test that spots tumor-specific DNA and protein biomarkers of early-stage pancreatic cancer. Tumors tend to shed their mutated DNA into the bloodstream, making it possible for scientists to use gene-sequencing technology to sift through the blood and fish out DNA molecules specific for cancer amid a wide sea of normal DNA circulating in the blood.

A gene-based test can distinguish harmless pancreatic cysts from cysts that are likely to become cancer. These fluid-filled cysts are found in more than 1 million patients each year who have undergone CT or MRI scans because of abdominal pain and swelling. Imaging and even examining the fluid inside the cysts does not provide precise markers for precancerous potential. A panel of genetic markers, combined with clinical expertise, can accurately differentiate among types of pancreatic cysts and identify cysts that are safe to watch over time and cysts that need to be removed.

Alison Klein, Ph.D.

We have one of the busiest pancreatic surgery programs in the world, and it has aided our expert in pioneering these types of pancreatic cancer precision medicine approaches. Many patients willingly provided tumor samples our scientists study to identify the molecular changes that cause pancreatic cancers to form and grow.

Alison Klein, Ph.D., a researcher in theSol Goldman Pancreatic Cancer Research Center, studies common gene variations that sometimes lead to pancreatic cancer.

“Most people who have them will never develop pancreatic cancer, but studying these changes can help us understand why some people develop the cancer,” says Klein. “Combining this information with other data we have on pancreatic cancer may help us figure out who is most at risk.”

Contact our Precision Medicine Center of Excellence for Pancreatic Cancer at 410-933-PANC (7262).

National Familial Pancreas Tumor Registry

The NFPTR Needs You!

The NFPTR is a research study aimed at identifying the causes of pancreatic cancer. We hope that our research will enable the early detection of pancreas cancer and lead to improved treatment of this disease, saving lives. The addition of more families to our study is critical to continue our progress.

Find out if you or your family qualifies to join the pancreas tumor registry.

Experts by Specialty

Our team provides treatment locations in Baltimore, Washington, D.C., and the surrounding metropolitan areas.

Specialties:

Medical Oncology

Nilo Azad, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Katie Bever, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Ana De Jesus-Acosta, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Ross C. Donehower, MD

Primary Location: Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville, Lutherville, MD
Won Jin Ho, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Daniel Laheru, MD

Primary Location: Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville, Lutherville, MD
Dung Le, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Valerie Lee, MD

Primary Location: Sibley Memorial Hospital, Washington, DC
Mike J. Pishvaian, MD PhD

Primary Location: Sibley Memorial Hospital, Washington, DC
Mark Yarchoan, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Neeha Zaidi, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Lei Zheng, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD

Surgery

Richard Andrew Burkhart, MD

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
William Burns, MD

Primary Location: Johns Hopkins Outpatient Center, Baltimore, MD
Michele Maiko Gage, MD

Primary Location: Sibley Memorial Hospital, Washington, DC
Jin He, MD PhD

Primary Location: Johns Hopkins Outpatient Center, Baltimore, MD
Gabriel David Ivey, MD

Primary Location: Sibley Memorial Hospital, Washington, DC
Kelly Jeanne Lafaro, MD MPH

Primary Location: Skip Viragh Outpatient Cancer Center, Baltimore, MD
Michail Mavros, MD

Primary Location: Sibley Memorial Hospital, Washington, DC
Chris Shubert, MD MSHA

Primary Location: Johns Hopkins Outpatient Center, Baltimore, MD

Radiation Oncology

Victoria Jane Croog, MD

Primary Location: Sibley Memorial Hospital, Washington, DC
Stephen C Greco, MD

Primary Location: Johns Hopkins Health Care & Surgery Center — Bethesda, Bethesda, MD
Rachit Kumar, MD

Primary Location: Sibley Memorial Hospital, Washington, DC
Jeffrey Meyer, MD MS

Primary Location: Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD
Amol K. Narang, MD

Primary Location: Sidney Kimmel Comprehensive Cancer Center, Baltimore, MD

Pathology

Syed Z. Ali, MD

Primary Location: Johns Hopkins Bayview Medical Center, Baltimore, MD
Robert Albert Anders, MD PhD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Ralph H. Hruban, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Scott E. Kern, MD
Liz Dell Thompson, MD PhD
Laura Delong Wood, MD PhD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD

Radiology

Linda Chu, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Elliot K. Fishman, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Karen M. Horton, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Pamela Johnson, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Satomi Kawamoto, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Atif Zaheer, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Stefan Zimmerman, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD

Diagnostic Radiology

Katarzyna J. Macura, MD PhD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD

Gastroenterology

Mimi Canto, MD MHS

Primary Location: Johns Hopkins Endoscopy & Surgery Center - Columbia, Columbia, MD
Michael G. Goggins, MD

Primary Location: Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville, Lutherville, MD
Mouen Khashab, MD

Primary Location: Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville, Lutherville, MD
Eun Ji Shin, MD

Primary Location: Johns Hopkins Endoscopy & Surgery Center - Columbia, Columbia, MD
Vikesh Singh, MD MSC

Primary Location: Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville, Lutherville, MD

National Familial Pancreas Tumor Registry

Ralph H. Hruban, MD

Primary Location: The Johns Hopkins Hospital, Baltimore, MD
Alison Klein, PhD

Nursing

Maureen Berg, R.N.
Heather Davis Bruning, R.N.
Anna Ferguson, R.N.
Carol Judkins, R.N.
Holly Kemberling, R.N.
Ellen Lilly-Foreman, R.N.
Shelia Linden, R.N.
Beth Onners, R.N.
Cancer Vaccine Research Nurse
Susan Petrie, R.N.
Katrina Purtell, R.N.
Charlene Rogers, R.N.
Rosalind Walker, R.N.
Brad Wilt, R.N.

Nurse Practitioners

Paige Griffith R.N., N.P.
Rachel Klein, R.N., N.P.
Keith McIntyre, N.P.
Amy Ryan, R.N., N.P.
Cara Wilt, R.N., N.P.

Research Nurse

Susan Sartorious-Mergenthaler, R.N.

Surgery: Physician Assistants

Lara Espin
Lindsey Manos
Christie Brown

Nutrition

Mary-Eve Brown, R.D., L.D.N.

Social Work

Nicole Garbarino, LMSW

Sterile fluids supply information

Research

Meet Our Experts

Expertise Matters

Early Detection

National Familial Pancreas Tumor Registry

Experts by Specialty

Medical Oncology

Surgery

Radiation Oncology

Pathology

Radiology

Diagnostic Radiology

Gastroenterology

National Familial Pancreas Tumor Registry

Nursing

Nurse Practitioners

Research Nurse

Surgery: Physician Assistants

Nutrition

Social Work