Mpox Recurrence and Tecovirimat Resistance in a Patient With Advanced Human Immunodeficiency Virus Disease
Research Publication Date:
09/23/2024
Research Topics:
Research Citation:
Griffith DC, Fall A, Carter M, Traut CC, Sop J, Hansoti B, Gebo KA, Mostafa HH, Blankson JN. Mpox Recurrence and Tecovirimat Resistance in a Patient With Advanced Human Immunodeficiency Virus Disease. Open Forum Infect Dis. 2024 Sep 23;11(10):ofae549. doi: 10.1093/ofid/ofae549. PMID: 39371365; PMCID: PMC11452800.
Research Abstract
We present a case of mpox recurrence in a transgender woman with AIDS. Her recurrent lesions required several courses of antiviral therapy over a 5-month period and her monkeypox viral genome was subsequently noted to have tecovirimat resistance mutations. Interestingly, she developed a robust orthopoxvirus-specific T-cell response.