The COVID-19 pandemic has shed light on the mental health of clinicians.1., 2., 3. More than half of health care workers report anxiety about transmitting COVID-19 to family members, concerns about their own health, difficulty balancing childcare and homeschooling, demoralization, and difficulty achieving goal standards of medical care when COVID-19 surges overwhelm health systems. These persistent stressors likely have impacts on the ability of health care workers to provide comprehensive health care. In this issue of The Joint Commission Journal on Quality and Patient Safety, Brady and colleagues conducted a large, retrospective observational study reminding us that, although often unrecognized, depression and anxiety have been widespread among clinicians even prior to the COVID-19 pandemic.1 More specifically, they investigated data from 1,668 ambulatory visits linked to annual wellness surveys administered to clinicians at Boston Medical Center in 2017 and 2018. They found that a remarkable 34% of clinicians reported depression and/or anxiety. Furthermore, each standard deviation increase in a clinician's composite depression and anxiety score was associated with a 28% increase in the odds of an inappropriate antibiotic prescription for an acute respiratory tract infection (ARTI), uncovering a concerning association between clinician mental health and antibiotic prescribing. Although the current study was conducted in the pre-COVID-19 era, it is plausible that had this work been repeated during the height of the pandemic, the unique stressors imposed by the COVID-19 pandemic would have shown an even greater prevalence of depression and/or anxiety among clinicians.2., 3., 4.