We have previously gathered stakeholders in healthcare epidemiology, infection prevention, infusion nursing, and home infusion therapy using a modified Delphi approach to develop a pilot home infusion central line associated bloodstream infections (CLABSI) definition. Through a collaborative of five home infusion agencies in different regions of the country, we will work, to validate and benchmark this new home infusion CLABSI definition, test the impact of feeding benchmarked home infusion CLABSI data back to agencies on CLABSI rates, and implement a CLABSI prevention maintenance toolkit in home infusion therapy. The major outcomes of this work will be (1) a validated home infusion CLABSI surveillance definition, (2) a benchmark for home infusion CLABSI with a dashboard for dissemination of benchmarked rates, and (3) an understanding of the impact of a CLABSI prevention toolkit on home infusion CLABSI rates.