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Pediatric anesthesiologist and intensivist Sean Barnes discusses his research, which explores plasma biomarkers reflective of pathways implicated in delirium pathogenesis. This research aims to provide pediatric cardiac anesthesiologists and intensivists with the means to predict which patients are likely to develop delirium, and to possibly identify modifiable risk factors that will affect the approach of caring for children with congenital heart defects who are undergoing cardiopulmonary bypass surgery.