Ahmad Marashly, medical director of the pediatric epilepsy surgery program, discusses the role of epilepsy surgery in managing patients with drug-resistant epilepsy. About 70% of patients with epilepsy will respond to one or two antiseizure medications and maintain long-term seizure freedom. Patients with drug-resistant focal epilepsy should consider epilepsy surgery. Johns Hopkins has one of the few epilepsy centers in the country that can evaluate and perform surgery for these patients.