The King-Wai Yau Laboratory is interested in the area of sensory transduction. Specifically, we study visual transduction, the process by which the sense of vision is initiated. In our eyes, we have two primary photoreceptors-rods and cones-to absorb light and convert light into electrical signal, which is then transmitted to the brain for image formation. Rods are extremely sensitive and responsible for night vision, but cones are about 100-fold less sensitivity and responsible for daylight vision. We are studying the cellular and molecular details underlying rod and cone phototransduction, aiming to understand the mechanism of rod-cone difference. Our ultimate goal is to convert rods into cones, or cones into rods to rescue human vision loss.