Loading Complete
Jiang Qian

Jiang Qian, PhD

Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

Gender

Male

About Jiang Qian

Primary Academic Title

Professor of Ophthalmology

Background

Jiang Qian, Ph.D., is the Karl H. Hagen professor of ophthalmology at the Wilmer Eye Institute. His research focuses on retinal gene regulation and the application of bioinformatics to the study of gene expression and regulation.

Dr. Qian received an M.S. in computational biology from Shanghai Biochemistry Institute in Shanghai, China, and a Ph.D. in physical chemistry from the Max Planck Institute for Polymer Research in Mainz, Germany. He then completed a postdoctoral fellowship in bioinformatics at Yale University.

Additional Academic Titles

Professor of Oncology

Contact for Research Inquiries

Smith Building
400 N. Broadway
Baltimore, MD 21287

Phone: (443) 287-3882
jiang.qian@jhmi.edu

Research Interests

Retinal gene regulation

Lab Website

Wilmer Bioinformatics - Lab Website

Research Summary

The Wilmer bioinformatics lab develops and applies bioinformatics approaches to the study of gene regulation, with particular, but not exclusive, attention to the regulation of retinal gene expression. In particular, the lab is interested in understanding transcriptional networks and protein/DNA interactions.

We integrate large biological datasets and develop computational algorithms to predict regulatory mechanisms controlling coordinated gene expression in specific tissues and cell types in both development and disease.

Recently, we have been interested in analyzing gene expression, epigenetic regulation, and single-cell datasets to construct regulatory networks and cell-cell communication pathways.

Selected Publications

  • Gao T, Qian J. “EnhancerAtlas 2.0: an updated resource with enhancer annotation in 586 tissue/cell types across nine species.”, Nucleic Acids Res. 2020 Jan 8;48(D1):D58-D64.

  • Hoang T, Wang J, Boyd P, Wang F, Santiago C, Jiang L, Yoo S, Lahne M, Todd LJ, Jia M, Saez C, Keuthan C, Palazzo I, Squires N, Campbell WA, Rajaii F, Parayil T, Trinh V, Kim DW, Wang G, Campbell LJ, Ash J, Fischer AJ, Hyde DR, Qian J, Blackshaw S. “Gene regulatory networks controlling vertebrate retinal regeneration”, Science, 2020, 370: eabb8598.

  • Hu MW, Kim DW, Liu S, Zack DJ, Blackshaw S, Qian J. “PanoView: An iterative clustering method for single-cell RNA sequencing data”, PLoS Comput Biol. 2019 Aug 30;15(8):e1007040.

  • Wang J, Zibetti C, Shang P, Sripathi SR, Zhang P, Cano M, Hoang T, Xia S, Ji H, Merbs S, Zack DJ, Handa JT, Sinha D, Blackshaw S, Qian J. “ATAC-Seq analysis reveals a widespread decrease of chromatin accessibility in age-related macular degeneration”, Nat Communications, 2018, 9(1):1364.

  • Zhu H, Wang G, Qian J, “Transcription factors as readers and effectors of DNA methylation.” Nature Reviews Genetics, 2016, 17, 551-65.

Additional Training

Yale University, New Haven, Connecticut, 2001, Bioinformatics

Expertise

Education

Max Planck Institute

Ph.D., 1999

Shanghai Institute of Biochemistry - Shanghai

M.S., 1994

Shanghai Jiao Tong University

B.S., 1991