Dmitri Artemov, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Dmitri Artemov
Professional Titles
- Associate Director, Cancer Functional Imaging Core, the Sidney Kimmel Comprehensive Cancer Center
Primary Academic Title
Professor of Radiology and Radiological Science
Background
Dr. Dmitri Artemov is an Associate Professor in the Johns Hopkins Medicine Department of Radiology and Radiological Science and the Department of Oncology. He also serves as an Associate Director of the Cancer Functional Imaging Core, which provides dedicated molecular and functional imaging service to research funded by the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. He specializes in the development of molecular imaging technology to monitor drug delivery to tumors, drug release from tumor-targeted nanocarriers, and tumor response to therapy.
Dr. Artemov completed an M.S. in molecular physics at Moscow State University and received a Ph.D. in physics and mathematics from the Russian Academy of Sciences.
After postdoctoral fellowships in MR imaging and MR of cancer at the University of Wurzburg and Johns Hopkins, respectively, he joined the Johns Hopkins staff as an Instructor in the Department of Radiology in 1997 and became an Assistant Professor of Radiology in 1998. While working in that capacity, Artemov also completed an M.S. in biotechnology at Johns Hopkins. He became an Associate Professor of Radiology and Oncology in 2004.
Dr. Artemov is a member of the International Society for Magnetic Resonance in Medicine, the American Association for Cancer Research, and the Society for Molecular Imaging.
Centers and Institutes
Clinical Trials Summary
Learn more about clinical trials at the Johns Hopkins Kimmel Cancer Center.
Additional Academic Titles
Professor of Oncology
Research Interests
Imaging of drug delivery and drug resistance, Imaging of endothelial progenitor cells and their role in tumor angiogenesis, Molecular imaging
Lab Website
Dmitri Artemov Lab
- The Artemov lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. The lab focuses on 1) Use of advanced dynamic contrast enhanced-MRI and activated dual-contrast MRI to perform image-guided combination therapy of triple negative breast cancer and to assess therapeutic response. 2) Development of noninvasive MR markers of cell viability based on a dual-contrast technique that enables simultaneous tracking and monitoring of viability of transplanted stems cells in vivo. 3) Development of Tc-99m and Ga-68 angiogenic SPECT/PET tracers to image expression of VEGF receptors that are involved in tumor angiogenesis and can be important therapeutic targets. 4) Development of the concept of "click therapy" that combines advantages of multi-component targeting, bio-orthogonal conjugation and image guidance and preclinical validation in breast and prostate cancer models.
Core Facility
Cancer Functional Imaging Core
Research Summary
Dr. Artemov’s main research focus lies in the development of novel molecular imaging methods for highly sensitive and specific MR imaging of molecular targets. Using a combination of MRI and PET capabilities, he seeks to develop targeted theranostic agents and new methods for imaging of infiltrating progenitor cells in the context of tumor microenvironment.
Selected Publications
Kato Y, Artemov D. “Monitoring of release of cargo from nanocarriers by MRI/MR spectroscopy (MRS): significance of T2/T2* effect of iron particles.” Magn Reson Med. 2009 May; 61(5):1059-65. PMCID: PMC2718565
Mironchik Y, Winnard PT Jr, Vesuna F, Kato Y, Wildes F, Pathak AP, Kominsky S, Artemov D, Bhujwalla Z, Van Diest P, Burger H, Glackin C, Raman V. “Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer.” Cancer Res. 2005 Dec 1; 65(23):10801-9
Onuki Y, Jacobs I, Artemov D, Kato Y. “Noninvasive visualization of in vivo release and intratumoral distribution of surrogate MR contrast agent using the dual MR contrast technique.” Biomaterials. 2010 Sep; 31(27): 7132-8. PMCID: PMC2917222
Raman V, Artemov D, Pathak AP, Winnard PT Jr, McNutt S, Yudina A, Bogdanov A, Bhujwalla ZM. “Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model.” Cancer Res. 2006; 66(20): 9929-36
Zhu W, Okollie B, Artemov D. “Controlled internalization of her-2/neu receptors by cross-linking for targeted delivery.” Cancer Biol Ther. 2007 Dec; 6(12), 1960-6
Honors
- Fellow, International Society for Magnetic Resonance in Medicine, 1/1/09
- Fellowship of Alexander von Humboldt-Foundation, Germany, 1/1/92
Memberships
- American Association for Cancer Research
- International Society for Magnetic Resonance in Medicine
- Society for Molecular Imaging
Additional Training
Institute of Chemical Physics, Moscow, Russia,, 1988, Fellow; Institute of Chemical Physics and Service Center Bruker,, Moscow, Russia, 1991, Scientist; Dept. of Radiology, Johns Hopkins University, Baltimore, MD, 1998, Instructor; The Johns Hopkins University, Baltimore, MD, 1997, MR of Cancer; University of Wurzburg, Germany, Wurzburg, Germany, 1992, MR Imaging