
Betty Mae Tyler, BA
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
FemaleAbout Betty Mae Tyler
Primary Academic Title
Professor of Neurological Surgery
Background
Dr. Betty Tyler is a Professor of Neurosurgery at Johns Hopkins University. She runs a highly successful and productive laboratory and has a national reputation for stellar science in the field of translational research and local delivery of chemotherapeutic agents for brain tumor therapy. Dr. Tyler assisted in the preclinical studies that led to bringing Gliadel to brain tumor patients as a standard of care, and also evaluated the efficacy of the local delivery of Paclitaxel from a novel thermal gel depot through commercial funding. The data in these studies were the scientific bases of a multi-institutional Phase I clinical trial for patients with malignant glioma.
Dr. Tyler’s collaborative efforts with scientists within Johns Hopkins as well as with researchers throughout the United States have led to multiple scientific breakthroughs. In addition to publishing over 200 peer-reviewed articles she has mentored and taught over 400 neurosurgical residents, medical students, and undergraduate students in research design, surgical techniques and statistical analysis.
She directs her work toward therapeutic progress, and mentoring new scientists, with the goal of bringing effective therapies to patients with brain tumors and making a difference in the brain cancer research field.
Recent News Articles and Media Coverage
- In Mouse Study, New Gel Therapy Stops Dangerous Brain Tumors, US News (April 25, 2023)
- Innovative nanoparticle gene therapy system eliminates cancerous brain cells, JH Medicine (February 4, 2015)
- Combining Two 'Old Therapies' Packs a Powerful Punch Against Pediatric Brain Tumors,JH Medicine (November 3, 2021)
- This gel stops brain tumors in mice. Could it offer hope for humans, JHU Hub (April 24, 2023)
Research Interests
Brain tumors, Cancer chemotherapy, Pharmacology
Selected Publications
- Williams CH, Neitzel LR, Cornell J, Rea S, Mills I, Silver MS, Ahmad JD, Birukov KG, Birukova A, Brem H, Tyler B, Bar EE, Hong CC. GPR68-ATF4 Signaling Is a Novel Prosurvival Pathway in Glioblastoma Activated by Acidic Extracellular Microenvironment. Experimental Hematology & Oncology, 2024, 13:13.
- Aghabaglou F, Ainechi A, Abramson H, Curry E, Parvez Kaovasia T, Kamal S, Acord M, Mahapatra S, Pustavoitau A, Smith B, Azadi J, Son JK, Suk I, Theodore N, Tyler BM*, Manbachi A*. Ultrasound Monitoring of Microcirculation: An original study from the laboratory bench to the clinic. Microcirculation. 2022 May 24;e12770. doi: 10.1111/micc.12770. PMID: 35611457
- Pant A, Hwa-Lin Bergsneider B, Srivastava S, Kim T, Jain A, Bom S, Shah P, Kannapadi N, Patel K, Choi J, Cho KB, Verma R, Yu-Ju Wu C, Brem H, Tyler B, Pardoll DM, Jackson C, Lim M. CCR2 and CCR5 co-inhibition modulates immunosuppressive myeloid milieu in glioma and synergizes with anti-PD-1 therapy. Oncoimmunology. 2024 Apr 4;13(1):2338965. doi: 10.1080/2162402X.2024.2338965. eCollection 2024.PMID: 38590799
- Wang F, Huang Q, Su H, Sun M, Wang Z, Chen Z, Zheng M, Chakroun R, Monroe MK, Chen D, Wang Z, Gorelick N, Serra R, Wang H, Guan Y, Suk JS, Tyler B, Brem H, Hanes J, Cui H. Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma, PNAS, 2023, 120 (18) e2204621120.
- Buaron N, Mangraviti A, Wang Y, Liu A, Pedone M, Sankey E, Adar I, Nyska A, Goldbart R, Traitel T, Brem H, Tyler B, Kost J. Ultrasound inhibits tumor growth and selectively eliminates malignant brain tumor in vivo. Bioengineering & Translational Medicine, 2024;e10660.