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Brendan J. Canning, PhD
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
MaleAbout Brendan J. Canning
Primary Academic Title
Professor of Medicine
Background
Brendan J. Canning, Ph.D. is a Professor of Medicine at The Johns Hopkins University School of Medicine in Baltimore, Maryland. He joined the Division of Allergy and Clinical Immunology of the Department of Medicine in 1996. He has been or is currently Co-Editor-in-Chief or Associate Editor for six medical research journals. Dr. Canning has served as a scientific advisory board member and a consultant for many pharmaceutical and biotech companies. His research is sponsored by grants from the NIH and by collaborations with industry.
Centers and Institutes
Asthma and Allergy Center
Contact for Research Inquiries
5501 Hopkins Bayview Circle
Room 3A.24
Baltimore, MD 21224
Phone: (410) 550-2156
Fax: (410) 550-2130
Research Interests
Airway defensive reflexes, cough, reflex bronchospasm
Lab Website
Brendan J. Canning Lab
- Research in the Brendan J. Canning Lab is focused on mechanistic studies of the cough reflex. Through our work, we identified the afferent nerves that play an essential role in regulating cough. We have also been characterizing the CNS pathways regulating the cough reflex and interactions amongst various afferent nerve subtypes in regulating cough. We have identified key sites of integration of airway afferent nerve input and mechanisms by which afferent nerve subtypes act synergistically to regulate cough. Our experimental approaches include electrophysiological recordings, CNS microinjection techniques, in vivo preparations for monitoring cough and reflex bronchospasm, neuronal tracing and immunohistochemistry.
Research Summary
We study airway neural control. We have characterized the CNS pathways regulating airway defensive reflexes and the interactions amongst various afferent nerve subtypes in regulating these reflexes.
Selected Publications
Canning BJ, Mori N (2010). An essential element to cough gating identified in anesthetized guinea pigs. FASEB J., 24(10):3916-3926
Canning BJ, Mori N (2011). Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol, 300(2):R369-77
Chou YL, Mori M and Canning BJ (2018). Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs. Am J Physiol, 314(3):R489-R498
Krasteva G, Canning BJ, Hartmann P, Veres T, Papadakis T et al. (2011). Cholinergic chemosensory cells in the trachea regulate breathing. Proc Natl Acad Sci U.S.A., 108(23):9478 - 9483
Mazzone SB, Reynolds SR, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009). Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough. J Neurosci., 29(43):13662-13671
Professional Activities
Institutional Animal Care and Use Committee, 1/1/00
Additional Training
Johns Hopkins University School of Medicine, Baltimore, MD, 1996, Research Postdoctoral Fellowship, Division of Allergy & Clinical Immunology