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Brendan J. Canning

Brendan J. Canning, PhD

Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

Gender

Male

About Brendan J. Canning

Primary Academic Title

Professor of Medicine

Background

Brendan J. Canning, Ph.D. is a Professor of Medicine at The Johns Hopkins University School of Medicine in Baltimore, Maryland. He joined the Division of Allergy and Clinical Immunology of the Department of Medicine in 1996. He has been or is currently Co-Editor-in-Chief or Associate Editor for six medical research journals. Dr. Canning has served as a scientific advisory board member and a consultant for many pharmaceutical and biotech companies.  His research is sponsored by grants from the NIH and by collaborations with industry.

Centers and Institutes

Asthma and Allergy Center

Contact for Research Inquiries

5501 Hopkins Bayview Circle
Room 3A.24
Baltimore, MD 21224

Phone: (410) 550-2156
Fax: (410) 550-2130

Research Interests

Airway defensive reflexes, cough, reflex bronchospasm

Lab Website

Brendan J. Canning Lab

  • Research in the Brendan J. Canning Lab is focused on mechanistic studies of the cough reflex. Through our work, we identified the afferent nerves that play an essential role in regulating cough. We have also been characterizing the CNS pathways regulating the cough reflex and interactions amongst various afferent nerve subtypes in regulating cough. We have identified key sites of integration of airway afferent nerve input and mechanisms by which afferent nerve subtypes act synergistically to regulate cough. Our experimental approaches include electrophysiological recordings, CNS microinjection techniques, in vivo preparations for monitoring cough and reflex bronchospasm, neuronal tracing and immunohistochemistry.

Research Summary

We study airway neural control. We have characterized the CNS pathways regulating airway defensive reflexes and the interactions amongst various afferent nerve subtypes in regulating these reflexes.

Selected Publications

  • Canning BJ, Mori N (2010).  An essential element to cough gating identified in anesthetized guinea pigs.  FASEB J., 24(10):3916-3926

  • Canning BJ, Mori N (2011).  Encoding of the cough reflex in anesthetized guinea pigs. Am J Physiol, 300(2):R369-77

  • Chou YL, Mori M and Canning BJ (2018).  Opposing effects of bronchopulmonary C-fiber subtypes on cough in guinea pigs.  Am J Physiol, 314(3):R489-R498

  • Krasteva G, Canning BJ, Hartmann P, Veres T, Papadakis T et al. (2011). Cholinergic chemosensory cells in the trachea regulate breathing.  Proc Natl Acad Sci U.S.A., 108(23):9478 - 9483

  • Mazzone SB, Reynolds SR, Mori N, Kollarik M, Farmer DG, Myers AC, Canning BJ (2009).  Selective expression of a sodium pump isozyme by cough receptors and evidence for its essential role in regulating cough.  J Neurosci., 29(43):13662-13671

Professional Activities

Institutional Animal Care and Use Committee, 1/1/00

Additional Training

Johns Hopkins University School of Medicine, Baltimore, MD, 1996, Research Postdoctoral Fellowship, Division of Allergy & Clinical Immunology

Expertise

Education

Johns Hopkins Bloomberg School of Public Health

Ph.D., 1993

University of Maryland (College Park)

B.S., 1986