Marie-France Vidaver, PhD

Primary Academic Title

Assistant Professor of Radiology and Radiological Science

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Additional Academic Titles

Assistant Professor of Oncology

Research Interests

Applying magnetic resonance imaging and magnetic resonance spectroscopy to study the tumor microenvironment, cancer cachexia, Early detection of ovarian cancer, theranostic imaging

Lab Website

Marie-France Penet Lab - Lab Website

• The Penet lab is within the Division of Cancer Imaging Research in the Department of Radiology and Radiological Science. The lab research focuses on using multimodal imaging techniques to better understand the microenvironment and improve cancer early detection, especially in ovarian cancer. By combining MRI, MRS and optical imaging, we are studying the tumor microenvironment to understand the role of hypoxia, tumor vascularization, macromolecular transport and tumor metabolism in tumor progression, metastasis and ascites formation in orthotopic models of cancer. We also are studying the role of tumor-associated macrophages in tumor progression.

Research Summary

Dr. Penet has a strong background in imaging mice with MR techniques. Her imaging expertise began during her Ph.D. when she performed brain imaging studies of mice infected with Plasmodium berghei ANKA, parasites that induce the murine form of cerebral malaria. As a post-doctoral fellow in Pr. Zaver Bhujwalla’s laboratory, she worked on imaging orthotopic prostate cancer models. She has also performed surgical orthotopic implantation of prostate tumor pieces in male SCID mice.

Selected Publications

• Chen Z*, Penet MF*, Nimmagadda S, Li C, Banerjee SR, Winnard PT Jr, Artemov D, Glunde K, Pomper MG, Bhujwalla ZM. PSMA-Targeted Theranostic Nanoplex for Prostate Cancer Therapy.  ACS Nano. 6: 7752-62, (2012). PMCID:PMC4066818.

• Penet MF, Abou-Hamdan M, Coltel N, Cornille E, Grau GE, de Reggi M, Gharib B. “Protection against cerebral malaria by the low molecular-weight thiol panthetine” PNAS 105:1321-1326 (2008) (PMCID: PMC2234136).

• Penet MF, Gadiya MM, Krishnamachary B, Nimmagadda S, Pomper MG, Artemov D, Bhujwalla ZM. Metabolic signatures imaged in cancer-induced cachexia.  Cancer Res. 71: 6948-56, (2011). PMCID:PMC3217079

• Penet MF, Pathak AP, Raman V, Ballesteros P, Artemov D, Bhujwalla ZM. “Noninvasive Multi-parametric Imaging of Metastasis-Permissive Microenvironments in a Human Prostate Cancer Xenograft” Cancer Res 69:8822-9 (2009) (PMCID: PMC2783669).

• Penet MF, Shah T, Bharti S, Krishnamachary B, Artemov D, Mironchik Y, Wildes F, Maitra A, Bhujwalla ZM. Metabolic imaging of pancreatic ductal adenocarcinoma detects altered choline metabolism.  Clin Cancer Res. 21: 386-95, (2015). PMCID:PMC4297549

Honors

• Grant to study ovarian cancer with imaging, Tina Brozman Foundation, 1/1/12
• Travel Award, ISMRM, 1/1/09
• Travel Award, ISMRM, 1/1/07

Memberships

• American Association of Cancer Research
• International Society of Magnetic Resonance in Medicine

Additional Training

University of Aix-Marseille II, France, Marseille, France, 2002, Post Graduate Immunology; The JHU ICMIC Program of the Russell H. Morgan Department of Radiology and Radiological Science, the Johns Hopkins University School of Medicine, Baltimore, MD, 2010, Postdoctoral Fellow