Tanguy Lim-Seiwert, MD

Professional Titles

• Director, Head and Neck Cancer Oncology Disease Group
• Co-Director Bloomberg~Kimmel Institute for Immunotherapy/HNC Program

Primary Academic Title

Assistant Professor of Oncology

Background

Centers and Institutes

Bloomberg~Kimmel Institute for Cancer Immunotherapy

Find a Clinical Trial

Videos

• Causes and Risk Levels of HPV-Related Head and Neck Cancer

• Treatment of HPV-Related Head and Neck Cancers

• HPV-Related Head and Neck Cancers: An Overview

Additional Academic Titles

Assistant Professor of Otolaryngology-Head and Neck Surgery

Research Interests

Genomic Profiling, Immunologic Profiling

Selected Publications

• Chen YP, Wang YQ, Lv JW, Li YQ, Chua MLK, Le QT, Lee N, Colevas AD, Seiwert T, Hayes DN, Riaz N, Vermorken JB, O'Sullivan B, He QM, Yang XJ, Tang LL, Mao YP, Sun Y, Liu N, Ma J. Identification and validation of novel microenvironment-based immune molecular subgroups of head and neck squamous cell carcinoma: implications for immunotherapy. Annals of Oncology. 2018 Nov 8. [Epub ahead of print] PMID: 30407504

• Cristescu R, Mogg R, Ayers M, Albright A, Murphy E, Yearley J, Sher X, Liu XQ, Lu H, Nebozhyn M, Zhang C, Lunceford JK, Joe A, Cheng J, Webber AL, Ibrahim N, Plimack ER, Ott PA, Seiwert TY, Ribas A, McClanahan TK, Tomassini JE, Loboda A, Kaufman D. Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy. Science. 2018 Oct 12;362(6411)

• Kadri S, Long BC, Mujacic I, Zhen CJ, Wurst MN, Sharma S, McDonald N, Niu N, Benhamed S, Tuteja JH,  Seiwert TY, White KP, McNerney ME, Fitzpartrick C, Wang YL, Furtado LV, Segal JP;  Clinical Validation of a Next-Generation Sequencing Genomic Oncology Panel via Cross-Platform Benchmarking against Established Amplicon Sequencing Assays. J Mol Diagn.  2017 Jan; 19(1):43-56. doi: 10.1016/j.jmoldx.2016.07.012. Epub 2016 Nov 9. PMID: 27836695

• Saloura V, Fatima A, Zewde M, Kiyotani K, Bisson R, Park JH, Ikeda Y, Vougiouklakis  T, Bao R, Khattri A, Seiwert TY, Cipriani N, Lingen M, Vokes EE, Nakamura Y;  Characterization of the T-Cell Receptor Repertoire and Immune Microenvironment in Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck.  Clinical Cancer Rearch 2017 Aug 15;23(16):4897-4907. doi:10.1158/1078-042.CCR-17-0103. Epub 2017 Apr 25. PMID: 28442504

• Yearley JH, Gibson C, Yu N, Moon C, Murphy E, Juco J, Lunceford J, Cheng J, Chow LQM, Seiwert TY, Handa, Tomassini JE, McClanahan T.; PD-L2 Expression in Human Tumors: Relevance to Anti-PD-1 Therapy in Cancer. Clinical Cancer Research 2017 Jun 15;23(12):2158-3167. doi: 10.1158-0432.CCR-16-1761 PMID: 28619999

Honors

• Invited Wharton Professor/Lecturer - Yearly Wharton Research Retreat, The University of Toronto / Princess Margaret Cancer Center, Toronto, Canada, 1/1/16
• Travel award for the ASTRO/ASCO/AHNS Multidisciplinary Head and Neck Cancer Symposium; Palm Springs, CA: The Receptor Tyrosine Kinase c-MET as a Novel Therapeutic Target in Head and Neck Cancer, 1/1/07
• International Association for the Study of Lung Cancer (IASLC) Fellowship Award, The role of Heat Shock Protein 27 as a novel therapeutic target in Lung Cancer," 2-year research funding, 1/1/07
• ASCO Merit Award: pKDR/KDR ratio as a possible predictor of response in a Phase I/II study of erlotinib and bevacizumab for recurrent or metastatic Head and Neck Cancer, 1/1/07
• ASCO Young Investigator Award: Heat Shock Protein 27 - a potential prognostic marker and therapeutic target for Non-small Cell Lung Cancer, 1/1/06
• ASCO Merit Award: A phase I study of Bevacizumab (B) with Fluorouracil (F) and Hydroxyurea (H) with concomitant Radiotherapy (X) - B-FHX for poor prognosis head and neck cancer (HNC), 1/1/06
• CALGB Fellowship Award: The role of HSP70 and HSP27 in lung cancer, 1/1/05
• Travel award for the 5th Annual Targeted Therapies for the Treatment of Lung Cancer Conference, Steamboat, Colorado: The role of Heat Shock Proteins as novel treatments for Lung Cancer, 1/1/05
• Barton F. Haynes research award (Duke University Hospital) for resident-initiated research protocol: Effects of portable Ultrasound on resident central line insertion skills and procedural learning; a randomized controlled trial, 1/1/02

Memberships

• NCI Head and Neck Cancer Steering Committee
• American Association for Clinical Oncology (ASCO)
• Society for Immunotherapy of Cancer (SITC)
• American Association for Cancer Research (AACR)
• European Society of Clinical Oncology (ESMO)
• Fellow, Institute for Genomics and Systems Biology, The University of Chicago
• University of Chicago Phase II Consortium & Personalize Cancer Care Consortium (PCCC) ‚Äì Disease Oriented Group leader for Head and Neck Cancer
• Molecular Pathology Group Member - Development NGS cancer profiling assays
• Present Clinical Trials Review Committee (CTRC), The University of Chicago Comprehensive Cancer Center
• The Cancer Genome Atlas (TCGA)(NCI), Head and Neck Cancer Project Data Analysis / Writing Group

Professional Activities

Frontiers in Head and Neck Cancer, Chief editor