Sheela N. Magge, MD, MSCE

Professional Titles

• Director, Division of Pediatric Endocrinology
• Lawson Wilkins Chair of Pediatric Endocrinology

Primary Academic Title

Professor of Pediatrics

Background

Research Interests

Body compositioninsulin resistance, pediatric obesity and youth-onset type 2 diabetes.

Research Summary

Dr. Magge is a clinician investigator who is dedicated to improving the lives of children with type 2 diabetes, obesity and insulin resistance, as well as addressing the cardiovascular implications of these conditions.

In 2007, she received a National Institutes of Health (NIH) K23 award for her research on dyslipidemia and cardiovascular risk factors regarding pediatric obesity and type 2 diabetes. She was then a co-principal investigator of an NIH National Institute of Child Health and Human Development R01 study of cardiometabolic risk and obesity among adolescents with Down syndrome, which was awarded in 2012, and a co-investigator for the study Therapeutic Targets in African-American Youth with Type 2 Diabetes, which won an NIH Bench-to-Bedside award.

She is currently the principal investigator of a 2018 NIH National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) R01 award to study the differential cardiometabolic risk among South Asian adolescents compared with that for African-American and white peers, related to body composition. Dr Magge is the Johns Hopkins principal investigator of a new NIDDK U01: DISCOVERY study of risk factors for type 2 diabetes among youth. This study is following a group of youth at risk for type 2 diabetes to determine the greatest predictors of developing type 2 diabetes during childhood.

Dr. Magge is interested in how differences in body composition can modify cardiometabolic risk. Her expertise led to her appointment to the American Academy of Pediatrics Committee on Nutrition, on which she served from 2012 to 2018. Dr. Magge also has written numerous peer-reviewed publications on pediatric obesity, insulin resistance, body composition and type 2 diabetes.

PubMed

https://www.ncbi.nlm.nih.gov/sites/myncbi/10yydyeLxV25c/bibliography/54432615/public/?sort=date&direction=descending

Selected Publications

• Magge SN, Goodman E, Armstrong S, and the Committee on Nutrition, Section on Endocrinology, and Section on Obesity. The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering. Pediatrics. 2017. Jul 24. doi: 10.1542/peds.2017-1603. [Epub ahead of print]. PMID: 28739653

• Magge SN, Silverstein J, Elder D, Nadeau K, Hannon T. Evaluation and Treatment of Prediabetes in Youth. J Pediatrics. In Press

• Magge SN, Stettler N, Koren D, Levitt Katz LE, Gallagher PR, Mohler ER 3rd, Rader DJ.  Adiponectin is Associated with Favorable Lipoprotein Profile, Independent of BMI and Insulin Resistance, in Adolescents. Journal of Clinical Endocrinology and Metabolism. 2011; 96(5):1549-54. Epub 2011 Mar 2.  PMID: 21367935

• Magge SN, Zemel BS, Pipan ME, Gidding SS, Kelly A.  Cardiometabolic Risk and Body Composition in Youth With Down Syndrome. Pediatrics. 2019;144(2):e20190137

• de Ferranti SD, de Boer IH, Fonseca V, Fox CS, Golden SH, Lavie CJ, Magge SN, Marx N, McGuire DK, Orchard TJ, Zinman B, and Eckel RH.  Type 1 Diabetes Mellitus and Cardiovascular Disease – A Scientific Statement from the American Heart Association and American Diabetes Association.  Diabetes Care. 2014; 37(10), 2843-63. PMID: 25114297

Honors

Lawson Wilkins Endowed Chair of Pediatric Endocrinology, Johns Hopkins University School of Medicine

Memberships

• American Diabetes Association
• Pediatric Endocrine Society