Chuan-Hsiang Bear Huang, MD, PhD
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
MaleAbout Chuan-Hsiang Bear Huang
Primary Academic Title
Associate Professor of Pathology
Background
Chuan-Hsiang Bear Huang received his M.D. from National Taiwan University and completed two years of residency in internal medicine before obtaining his Ph.D. from the Graduate Program in Immunology at Johns Hopkins University, where he solved the structure of a PI3K protein that is one of the most important cancer drivers. His current research is focused on the dynamics, structure, and function of the signaling network involving RTK, Ras, PI3K, and ERK in cellular processes and cancer. Dr. Huang has numerous publications, including papers in Science, Nature Cell Biology, Nature Communications, and Cell. He has received many awards, including a Silver Medal at the International Mathematical Olympiad, the Mette Strand Award, the Julian Baumert Award, and the Damon Runyon Fellowship.
Additional Academic Titles
Associate Professor of Cell Biology
Lab Website
Huang Laboratory - Lab Website
- Our lab is interested in understanding the fundamental mechanisms of how cells move and implications in disease treatment. We use an interdisciplinary approach involving fluorescent live cell imaging, genetics, and computer modeling to study the systems level properties of the biochemical networks that drive cell migration.
Selected Publications
Huang CH, Mandelker D, Schmidt-Kittler O, Samuels Y, Velculescu VE, Kinzler KW, Vogelstein B, Gabelli SB, Amzel LM. "The structure of a human p110α/p85α complex elucidates the effects of oncogenic PI3Kα mutations." Science. 2007; 318(5857): 1744-8
Huang CH, Tang M, Shi C, Iglesias PA, Devreotes PN. "An excitable signal integrator couples to an idling cytoskeletal oscillator to drive cell migration." Nat Cell Biol. 2013; 15(11): 1307-1316
Tang M, Wang M, Shi C, Iglesias PA and Devreotes PN, Huang CH. "Evolutionarily conserved coupling of adaptive and excitable networks mediates eukaryotic chemotaxis." Nat Commun. 2014; 5: 5175
Yang JM, Bhattacharya S, West-Foyle H, Hung CF, Wu TC, Iglesias PA, Huang CH. Integrating chemical and mechanical signals through dynamic coupling between cellular protrusions and pulsed ERK activation. Nat Commun. 2018; 9(1), 4673
Yang JM, Chi WY, Liang J, Takayanagi S, Iglesias P, Huang CH. Deciphering cell signaling networks with massively multiplexed biosensor barcoding. Cell. 2021; 184(25), 6193–6206. PMID: 34838160. (Cover article)
Graduate Program Affiliations
Pathobiology