
Mohammad Hoque, DDS, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Mohammad Hoque
Primary Academic Title
Associate Professor of Otolaryngology-Head and Neck Surgery
Background
Dr. Hoque is an Associate Professor of Otolaryngology-Head & Neck Surgery, Urology and Oncology at Johns Hopkins University School of Medicine. Dr. Hoque completed dental and oral surgery training at the Dhaka Dental College, Dhaka University, Bangladesh. He then moved to Japan for the completion of Ph.D degree, where he also completed Advanced Clinical Training in Oral and Maxillofacial Surgery and Oncology. After training in Japan, he worked in the Head and Neck Cancer Research Division as a Postdoctoral Fellow under the mentorship of Dr. David Sidransky. He joined as a faculty member in 2006 in the Department of Otolaryngology-Head and Neck Surgery. His research interests includes: a) To understand molecular biologic basis of head and neck, lung and genitourinary cancer b) To develop and validate genetic and epigenetic approach for early cancer diagnosis, cancer risk assessment and cancer prognosis and c) To identify molecular alterations due to environmental exposures such as active smoking, passive smoking and arsenic.
Centers and Institutes
Additional Academic Titles
Associate Professor of Oncology
Research Interests
Develop and validate genetic and epigenetic approach for early cancer diagnosis, cancer risk assessment and cancer prognosis, Molecular biologic basis of head and neck, lung and genitourinary cancer
Selected Publications
BraitM, MunariE, LeBron C, Noordhuis MG, Begum S, Michalidi C, Gonzalez-Roibon N, Maldonado L, Sen T, Guerrero-Preston R, Cope L, Parrella P, Fazio VM, Ha PK, Netto GJ, Sidransky D and Hoque MO. Genome-Wide Methylation Profiling and the PI3K-AKT Pathway Analysis Associated with Smoking in Urothelial Cell Carcinoma. Cell Cycle. 2013 Feb 22; 12 (7). PMID: 23435205
Zhong X, Isharwal S, Naples JM, Shiff C, Veltri RW, Shao C, Bosompem KM, Sidransky D and Hoque MO. Hypermethylation of genes detected in urine from Ghanaian adults with bladder pathology associated with Schistosoma haematobium infection. PLoS One. 2013; 8 (3):e59089.PMID: 23527093
Ostrow KL, Michalidi C, Guerrero-Preston R, Hoque MO, Greenberg A, Rom W and Sidransky D. Cigarette smoke induces methylation of thetumor suppressor gene NISCH. Epigenetics, 2013 Mar 15; 8 (4). PMID: 23503203
BraitM, Maldonado L, Noordhuis M, Begum S, Loyo M, Poeta ML, BarbosaA, FazioVM, Angioli R, Rabitti C, Marchionni L, Graeff P, Zee AGJ, Wisman GB,Sidransky D, Hoque MO. Association of promoter methylation of VGF and PGP9.5 with ovarian cancer progression. PLoS One. 2013 Sep 27;8 (9):e70878. doi: 10.1371/journal.pone.0070878. PMID: 24086249
Enrico Munari, Luigi Marchionni, Apurva Chitre, Masamichi Hayashi, Guido Martignoni, Matteo Brunelli, Stefano Gobbo, Pedram Argani, Mohamad Allaf, Hoque MO, George J. Netto. Clear cell papillary renal cell carcinoma: microRNA expression profiling and comparison with clear cell renal cell carcinoma and papillary renal cell Carcinoma. Human Pathology 01/2014 Hum Pathol. 2014 Jun;45(6):1130-8. doi: 10.1016/j.humpath.2014.01.013. Epub 2014 Jan 31. (Corresponding author). PMID: 24703100
Maldonado L, Brait M, Loyo M, Sullenberger L, Wang K, Peskoe SB, Rosenbaum E, Howard R, Toubaji A, Albadine R, Netto GJ, Hoque MO, Platz EA, Sidransky D. GSTP1 promoter methylation is associated with recurrence in early stage prostate cancer. J Urol. 2014 Apr 21. pii: S0022-5347(14)03413-2. doi: 10.1016/j.juro.2014.04.082. PMID: 24769028
Izumchenko EG, Chang X, Michailidi C, Kagohara LT, Ravi R, Paz K, Brait M, Hoque MO, Ling S, Bedi A, Sidransky D. The TGFβ-miR200-Mig6 pathway orchestrates the EMT-associated kinase switch that induces resistance to EGFR inhibitors. Cancer Res. 2014 May 15. PMID: 24830724
Hayashi M, Bernert H, Kagohara LT, Maldonado L, Brait M, Schoenberg M, Bivalacqua T, Netto GJ, Koch W, Sidransky D, Hoque MO. Epigenetic inactivation of VGF associated with Urothelial Cell Carcinoma and its potential as a non-invasive biomarker using urine. Oncotarget. 2014 May 7. PMID: 24830820
Maldonado L, Brait M, Michailidi C, Munari E, Driscoll T, Schultz L, Bivalacqua T, Schoenberg M, Sidransky D, Netto GJ and Hoque MO. An epigenetic marker panel for recurrence risk prediction of low grade papillary urothelial cell carcinoma (LGPUCC) and its potential use for surveillance after transurethral resection using urine. Oncotarget, 2014, Jun 23. PMID: 24980822
MunariM, ChauxA, Maldonado L, CompératE, BivalacquaTJ, Hoque MO, Netto GJ. Cyclin A1 Expression is Associated with Tumor Progression in pT1 Urothelial Carcinoma of Bladder: A Tissue Microarray Study of 149 Patients Treated by Transurethral Resection. Histopathology, 2014 Jul 12. doi: 10.1111/his.12499. [Epub ahead of print] PMID: 25039670 (corresponding author).
Honors
- Career Development Award (Cervical Spore), 1/1/08
- Young Investigator Award (IASLC), 1/1/07
- Young Clinical Scientist Award (FAMRI), 1/1/06
- AACR-Astra Zenaca Scholar-in-Training Award at 95th Annual Meeting of American Association for Cancer Research, 1/1/04
- AACR-Busch Travel Fund Scholar-in-Training Award at 94th Annual Meeting of American Association for Cancer Research, 1/1/03
- JSPS (Japan Society for Promotion of Science) Fellowship, 1/1/99
- Fuji Otsuka International fellowship, 1/1/98
- Monbusho (Ministry of Education) Scholarship, 1/1/93
- Dhaka Board and Dhaka University Outstanding student Scholarship, 1/1/83
Lectures & Presentations
- Action at a Distance: Epigenetic Silencing in Cancer, 1/11/08
- Association Between Lifestyle Factors and CpG Island Methylation in a Cancer-free Population, Cancer Prevention & Control Communication Network, Johns Hopkins Bloomberg School of Public Health, Baltimore, 1/25/10
- Bladder Cancer Resulting from Exposure to Arsenic: Potential Screening Tool for Risk Assessment and Early Detection, University of Arizona, 1/22/12
- Cancer Methylome, Anderson Cancer Institute, Mercer University, 1/29/09
- Detection of promoter hypermethylation of multiple genes in the tumor, 95th Annual Meeting of American Associationfor Cancer Research, 1/1/03
- Discovery and Implication of Genetic and Epigenetic Molecular Markers of Cancer, 1/7/08
- Emerging Epigenetic Biomarkers for Cancer Diagnosis and Implication for Prevention and Treatment, 1/8/08
- Environmental Influences on Tumor Heterogeneity and Personalized Management of Cancer Patients: Opportunities and Challenges. University of Oklahoma Health Sciences Center, Oklahoma, 1/11/14
- Epigenetic Alterations related to Oral Diseases and Major Smoking Related Cancers: Scientific Evidence and Challenges Ahead. The 68th Japanese Stomatology Annual Meeting, Tokyo, 1/9/14
- Epigenetic Silencing in Cancer: From Discovery to Clinical Implications, 1/9/08
- Fundamentals of Cancer: Cause to Management, Macon, 1/22/10
- Genetic and Epigenetic Alterations in Cancer and its Clinical Implications, Bangladesh, 1/22/09
- Genetic and Epigenetic Alterations in Bladder Cancer Progression and Diagnosis, 1/1/05
- Genetic and Epigenetic Alterations in Bladder Cancer: From Bench to Bedside. Department of Urology, The University of Texas M.D. Anderson Cancer Center, 1/28/05
- Genetic and Epigenetic Alterations in Cancer and its Clinical Implications, Shahbagh, 1/21/09
- Genetic and Epigenetic Alterations in Human Cancer, JHUSOM, 1/16/06
- Genetic and Epigenetic Alterations in Human Cancer: from Bench to Bedside, Seattle, 1/1/05
- Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside, Augusta, 1/1/06
- Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside, Iowa City, 1/18/06
- Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside, New Orleans, 1/16/06
- Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside, 1/29/07
- Genetic and Epigenetic Alterations in Human Cancer: From Bench to Bedside, San Diego, 1/21/07
- Genomic to the Epigenomic Era: Steps Towards Biomarker Discovery, Barcelona, 1/5/09
- Harnessing Epigenetic Biomarkers: From Discovery to Clinical Implications, 1/10/08
- Harnessing Molecular Biomarkers: From Bench to Bedside, School of Medicine, 1/18/08
- High-throughput molecular analysis of urine sediment for the detection of bladder cancer by high-density single-nucleotide polymorphism array Venue: 94th Annual Meeting of American Associationfor Cancer Research, 1/1/02
- Human Biobank : Advancing the Vision of Personalized Medicine, Bangabandhu Sheikh Mujib Medical University, Shahbagh, 1/17/09
- Integrated Genomic and Epigenomic Approach for Biomarker Development and Non-invasive Diagnosis of Cancer, 1/1/06
- Marching from the Genomic to the Epigenomic Era:Epigenetic Marks as Detectors, Sultan Qaboos University, College of Medicine & Health Sciences, Oman, 1/24/11
- Methylation Markers for Early Detection of Prostate Cancer and Risk Prediction, Lisbon, 1/16/08
- Molecular Alterations in Bladder Cancer: From the Laboratory to Clinical Applications, University of New Mexico, 1/31/08
- Molecular Alterations in Cancer and its Clinical Implications, Viale Padre PIO 71013, San Giovanni Rotondo, 1/15/08
- Molecular Heterogeneity and Personalized Cancer Medicine: Are We on The Right Track? Dokkyo Medical University School of Medicine, Mibu-machi, Shimotsuga-gun, Tochigi, 1/12/14
- Promoter Methylation of Prostate Cancer Specific Genes in low-income African American Adults, 1/1/08
- The Cancer Epigenome and the Epigenetic Diagnostics of Cancer, SKCC, 1/27/07
- The Cancer Methylome: Epigenetic Biomarkers for Human Cancer, 1/6/08
- The Cancer Methylome: From Discovery to Clinical Implications, Cancer Center and School of Public Health., 1/15/08
- Translational Cancer Research: Converting "OMICS" into Personalized Patient Management. Boston University School of Medicine, Boston, 1/31/14
Memberships
- American Association of Cancer Research (AACR), Member
- Bangladesh Dental Society, Member
- International Association for the Study of Lung Cancer (IASLC), Member
- Japanese Cancer Association, Member
- Maryland Cancer Collaborative group (Subgroup: Early Detection and Treatment)., Member