Kenneth R. Cooke, MD

Professional Titles

• Herman and Walter Samuelson Professor of Oncology
• Director, Pediatic Blood and Marrow Transplantation Program

Primary Academic Title

Professor of Oncology

Background

Centers and Institutes

• Pediatric Oncology Program
• Sidney Kimmel Comprehensive Cancer Center

Clinical Trial Keywords

Bone Marrow Transplantation, acute and chronic pulmonary dysfunction and graft-vs-host disease that occurs after BMT.

Clinical Trials Summary

Bone Marrow Transplant

Research Interests

Inflammatory mechanisms responsible for endothelial activation and injury after allogeneic BMT. Soluble and cellular effector mechanisms that contribute to non-infection lung injury and graft-versus-host disease in both the acute and chronic settings.

Selected Publications

• Cooke KR, Gerbitz A, Crawford JM, Teshima T, Hill GR, Tesolin A, Rossignol DP, Ferrara JLM. LPS antagonism reduces graft-versus-host disease and preserves graft-versus-leukemia activity after experimental bone marrow transplantation.  J Clin Invest 2001; 107: 1581-1589.

• Hildebrandt GC, Olkiewicz KM, Corrion LA, Chang Y, Clouthier S, Liu C, Cooke KR. Donor-derived tumor necrosis factor-alpha regulates pulmonary chemokine expression and the development of idiopathic pneumonia syndrome after allogeneic bone marrow transplantation. Blood 2004; 104: 586-593.

• Schlatzer DM, Dazard JE, Ewing RM, Ilchenko S, Rana G, Yanik G, Chance MR, Cooke KR. Human biomarker discovery and predictive models for disease progression for idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Molec Cellular Proteomics 2012; 11: M111.015479. PMCID 3433920.

• Yanik GA, Grupp SA, Pulsipher MA, Levine JE, Schulz KR, Wall DA, Langholz B, Dvorak CC, Alangaden K, Goyal RK, White ES, Collura JM, Skeens MA, Eid S, Pierce EM, Cooke KR, TNF-receptor inhibitor therapy for the treatment of children with idiopathic puenmonia syndrome. A joint Pediatric Blood and Marrow Transplant Consortium and Children’s Oncology Group Study (ASCT0521). Biol Blood Marrow Transplant 2015; 21(1): 67-73. PMCID 4286345.

• Yanik GA, Ho V, Levine JL, White E, Braun T, Antin J, Ferrara JLM, Cooke KR. The impact of soluble tumor necrosis factor receptor: etanercept on the treatment of idiopathic pneumonia syndrome following allogeneic stem cell transplantation. Blood 2008; 112:3073-81. PMCID 3045267.