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Warren L. Grayson

Warren L. Grayson, PhD

Highlights

Languages

  • English

Gender

Male

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Warren L. Grayson

Professional Titles

  • Director, Laboratory for Craniofacial and Orthopaedic Tissue Engineering

Primary Academic Title

Professor of Biomedical Engineering

Background

Dr. Warren L. Grayson is an assistant professor of biomedical engineering at Johns Hopkins University School of Medicine. His research examines the underlying mechanisms that regulate tissue development and uses computational and experimental tools to help engineer complex functional tissue constructs for use in regenerative medicine.

The director of the Johns Hopkins Laboratory for Craniofacial and Orthopaedic Tissue Engineering, Dr. Grayson also serves on the faculty of the Translational Tissue Engineering Center and Institute for NanoBioTechnology, both at Johns Hopkins.

He earned his Ph.D. biomedical engineering from Florida State University and completed his postdoctoral training at Columbia University. He holds a B.Sc. in chemical and process engineering from The University of the West Indies. He joined the Johns Hopkins faculty in 2009.

His lab is currently looking at the spatial and temporal regulation of stem-cell differentiation in 3-D constructs with the goal of developing clinically useful engineered grafts.

Dr. Grayson’s research on bioreactor design and engineering anatomically shaped bone grafts has garnered widespread national and international attention, with articles appearing in publications including The New York Times and Science Translational Medicine and on The BBC.

Dr. Grayson has authored a number of original and review articles and book chapters and holds two patents for bioreactor designs. 

Centers and Institutes

Videos

Research Interests

Engineering functional craniofacial and orthopaedic constructs for use in therapeutic applications

Lab Website

Grayson Lab for Craniofacial and Orthopaedic Tissue Engineering - Lab Website

  • The Grayson Lab focuses on craniofacial and orthopaedic tissue engineering. Our research addresses the challenges associated with spatio-temporal control of stem cell fate in order to engineer complex tissue constructs. We are developing innovative methods to guide stem cell differentiation patterns and create patient-specific grafts with functional biological and mechanical characteristics. We employ engineering techniques to accurately control growth factor delivery to cells in biomaterial scaffolds as well as to design advanced bioreactors capable of maintaining cell viability in large tissue constructs. These technologies are used to enable precise control of the cellular microenvironment and uniquely address fundamental questions regarding the application of biophysical cues to regulate stem cell differentiation.

Research Summary

The Grayson Lab for Craniofacial and Orthopaedic Tissue Engineering seeks to address the challenges associated with engineering functional craniofacial and orthopaedic constructs for use in therapeutic applications. They are developing innovative methods using stem cells to create patient-specific grafts with the necessary biological and mechanical characteristics to facilitate functional in vivo integration.

The lab employs engineering techniques to design advanced bioreactors capable of maintaining cell viability in large tissue constructs. These bioreactors also enable precise control of the cellular microenvironment and can uniquely address fundamental questions about the application of biophysical cues to regulate stem cell differentiation.

Google Scholar

http://scholar.google.com/citations?user=0l3OJnEAAAAJ&hl=en&oi=ao

PubMed

http://www.ncbi.nlm.nih.gov/pubmed?Db=pubmed&Cmd=Search&Term=Warren+Grayson[Author]

Selected Publications

  • “Temple JP, Yeager K, Bhumiratana S, Vunjak-Novakovic G, Grayson WL.” Bioreactor Cultivation of Anatomically Shaped Human Bone Grafts. Methods Mol Biol. 2013 Sep 7. [Epub ahead of print]

  • Hung BP, Salter EK, Temple J, Mundinger GS, Brown EN, Brazio P, Rodriguez ED, Grayson WL. “Engineering bone grafts with enhanced bone marrow and native scaffolds.” Cells Tissues Organs. 2013;198(2):87-98. doi: 10.1159/000353696. Epub 2013 Sep 6.

  • Hutton DL, Moore EM, Gimble JM, Grayson WL. “Platelet-derived growth factor and spatiotemporal cues induce development of vascularized bone tissue by adipose-derived stem cells.” Tissue Eng Part A. 2013 Sep;19(17-18):2076-86. doi: 10.1089/ten.TEA.2012.0752. Epub 2013 May 17.

  • Temple JP, Hutton DL, Hung BP, Huri PY, Cook CA, Kondragunta R, Jia X, Grayson WL. “Engineering anatomically shaped vascularized bone grafts with hASCs and 3D-printed PCL scaffolds.” J Biomed Mater Res A. 2014 Feb 8. doi: 10.1002/jbm.a.35107. [Epub ahead of print]

  • Zhang S, Liu X, Barreto-Ortiz SF, Yu Y, Ginn BP, DeSantis NA, Hutton DL, Grayson WL, Cui FZ, Korgel BA, Gerecht S, Mao HQ. “Creating polymer hydrogel microfibres with internal alignment via electrical and mechanical stretching.” Biomaterials. 2014 Mar;35(10):3243-51. doi: 10.1016/j.biomaterials.2013.12.081. Epub 2014 Jan 15.

Honors

  • Career Enhancement Award, American Society for Bone and Mineral Research (ASBMR), 1/1/13
  • Musculoskeletal Pilot and Feasibility Grant Award, Johns Hopkins University (JHU) Center for Musculoskeletal Research, 1/1/13
  • Musculoskeletal Pilot and Feasibility Grant Award, JHU Center for Musculoskeletal Research, 1/1/12
  • Outstanding Young Engineer, Maryland Science Center, 1/1/10
  • Career Development Award, Orthopaedic Research Society, 1/1/07

Additional Training

Columbia University, New York, NY, 2009, Biomedical Engineering