Tamara Lotan, MD
Clinical and Laboratory Pathology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Tamara Lotan
Professional Titles
- Acting Director of Urologic Pathology, The Johns Hopkins Hospital
- Deputy Director for Research Affairs, Department of Pathology
Primary Academic Title
Professor of Pathology
Background
Dr. Tamara Lotan is a Professor of Pathology, Oncology and Urology at the Johns Hopkins University School of Medicine. Her area of clinical expertise is urologic pathology.
Dr. Lotan received her medical degree from the University of Chicago Pritzker School of Medicine. She completed her residency in anatomic pathology at the University of Chicago Hospitals and performed a fellowship in urologic pathology at the Johns Hopkins University School of Medicine.
She is a urologic pathologist and physician-scientist whose laboratory studies tissue-based predictive and prognostic biomarkers in prostate cancer. The group has a particular interest in the molecular contributors to prostate cancer health disparities. Her group also studies mTOR signaling and its role in tumorigenesis, with a focus on renal oncogenesis.
Dr. Lotan is engaged in research training and is the co-PI of the OPTIC T32 in pathology, enabling pathology residents to engage in 2-3 years of laboratory research. She is currently the Deputy Director for Research Affairs in the Department of Pathology.
Centers and Institutes
Additional Academic Titles
Joint Appointment in Urology, Professor of Oncology
Research Interests
Prostate cancer, kidney cancer
Research Summary
Dr. Tamara Lotan is a urologic pathologist who studies how oncogenic signaling pathways regulate epithelial morphogenesis during embryonic development and tumorigenesis. Using novel transgenic mouse models combined with human tumor tissue samples, Dr. Lotan is defining the roles of these critical signals in epithelial development and tumor progression.
Selected Publications
- Salles DC, Asrani K, Woo J, Vidotto T, Liu HB, Vidal I, Matoso A, Netto GJ, Argani P, Lotan TL. GPNMB expression identifies TSC1/2/mTOR-associated and MiT family translocation-driven renal neoplasms. J Pathol. 2022. 257(2):158-171; PMID: 35072947.
- Asrani K, Woo J, Mendes AA, Schaffer E, Vidotto T, Villanueva CR, Feng K, Oliveira L, Murali S, Liu HB, Salles DC, Lam B, Argani P, Lotan TL. An mTORC1-mediated negative feedback loop constrains amino acid-induced FLCN-Rag activation in renal cells with TSC2 loss. Nat Commun. 2022;13(1):6808. PMID: 36357396.
- Mendes AA, Lu J, Kaur HB, Zheng S, Xu J, Hicks J, Weiner AB, Schaeffer EM, Ross AE, Balk SP, Taplin M-E, Lack NA, Tekoglu E, Maynard JP, De Marzo AM, Antonarakis ES, Sfanos KS, Joshu CE, Shenderov E*, Lotan TL*. Association of B7-H3 Expression with Racial Ancestry, Immune Cell Density, and AR Activation in Prostate Cancer. Cancer. 2022; 15;128(12):2269-2280. *Equal Contribution. PMID: 35333400.
- Vidotto T, Imada EL, Faisal F, Murali S, Mendes AA, Kaur H, Zheng S, Xu J, Schaeffer EM, Isaacs WB, Sfanos KS, Marchionni L, Lotan TL. Association of self-identified race and genetic ancestry with the immunogenomic landscape of primary prostate cancer_. JCI Insight_. 2023; 8(3)e162409. PMID: 36752203.
- Erak E, Oliveira LD, Mendes AA, Dairo O, Ertunc O, Kulac I, Baena-Del Valle JA, Jones T, Hicks JL, Glavaris S, Guner G, Vidal ID, Markowski M, de la Calle C, Trock BJ, Meena A, Joshi U, Kondragunta C, Bonthu S, Singhal N, De Marzo AM, Lotan TL. Predicting Prostate Cancer Molecular Subtype with Deep Learning on Histopathologic Images. Mod. Pathol. 2023_;_ 36(10):100247. PMID: 37307876.
Honors
- 2022-Elected to Interurban Clinical Club
Memberships
- College of American Pathology
- International Society of Urologic Pathology
- United States and Canadian Academy of Pathology
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Pathology, 2008University of Chicago Medicine
Residency, Anatomic Pathology, 2007University of Chicago Medicine
Residency, Anatomic Pathology, 2005University of Chicago Pritzker School of Medicine
Medical Education, MD, 2003Board Certifications
Anatomic Pathology
American Board of Pathology, 2007Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)