James Hamilton, MD
Gastroenterology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About James Hamilton
Professional Titles
- Director of Hepatology
- Interim Director, Division of Gastroenterology and Hepatology
Primary Academic Title
Associate Professor of Medicine
Background
Dr. Hamilton is an Associate Professor of Medicine in the Division of Gastroenterology and Hepatology. He is the Interim Director, Division of Gastroenterology and Hepatology and the Director of Hepatology for Johns Hopkins Medicine.
His clinical specialties include Wilson Disease, Cystic Fibrosis related liver disease, liver transplantation, hepatocellular carcinoma, cirrhosis, portal hypertension, acute and chronic viral, non-alcoholic fatty liver disease (NASH), autoimmune, and cholestatic liver disease.
His research interests include the copper homeostasis and its regulation of lipid metabolism and liver injury, the fundamental mechanisms regulating liver fibrosis, and the molecular genetics of hepatocellular carcinoma and early detection biomarkers.
Dr. Hamilton is a 2005 recipient of the National Institutes of Health/ National Research Scholar Award for gastroenterology and hepatology.
Centers and Institutes
Clinical Trials Summary
A Phase 3, Double-Blind Randomized, Long-term, Placebo-controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid (OCA) in subjects with Non-Alcoholic Steatohepatitis (REGENERATE)
A Phase 2, Double-blind, Randomized, Placebo-controlled, Dose-finding Study to Evaluate the Safety, Tolerability and Efficacy of Volixibat Potassium, an Apical Sodium-Dependent Bile Acid Transporter Inhibitor (ASBTi) in Adults with Nonalcoholic Steatohepatitis (NASH)
Sofusbuvir and Ledipasvir in HIV/HCV Coinfected Pre and Post Liver Transplant
A Phase II Randomized Multicenter Placebo-Controlled Blinded Study of Sorafenib Adjuvant Therapy in High Risk Orthotopic Liver Transplant (OLT) Recipients with Hepatocellular Carcinoma (HCC)
Additional Academic Titles
Associate Professor of Physiology
Contact for Research Inquiries
720 Rutland Ave
Ross 921
Baltimore, MD 21205
Research Interests
Early detection biomarker discovery for hepatocellular carcinoma, Wilson Disease: Copper homeostasis and regulation of lipid metabolism and liver injury. Pathogenesis of Liver fibrosis and cancer
Lab Website
James Hamilton Lab
- The main research interests of the James Hamilton Lab are the molecular pathogenesis of hepatocellular carcinoma and the development of molecular markers to help diagnose and manage cancer of the liver. In addition, we are investigating biomarkers for early diagnosis, prognosis and response to various treatment modalities. Results of this study will provide a molecular classification of HCC and allow us to identify targets for chemoprevention and treatment. Specifically, we extract genomic DNA and total RNA from liver tissues and use this genetic material for methylation-specific PCR (MSP), cDNA microarray, microRNA microarray and genomic DNA methylation array experiments.
Selected Publications
Hamilton JP, Koganti L, Muchenditsi A, Pendyala VS, Huso D, Hankin J, Murphy RC, Huster D, Merle U, Mangels C, Yang N, Potter JJ, Mezey E, Lutsenko S. Activation of LXR/RXR Pathway Ameliorates Liver disease in ATP7b-/- (Wilson disease) mice. Hepatology 2016; 63(6): 1828-41. PMID: 26679751
Hamilton JP, Potter JJ, Koganti L, Meltzer SJ, Mezey E. Effects of Vitamin D stimulation of Thioredoxin Interacting Protein in hepatocellular carcinoma. Hepatol Res. 2014; 44(13): 1357-66. PMID: 24451003
Karthikeyan S, Potter JJ, Geschwind JF, Sur S, Hamilton JP, Vogelstein B, Kinzler KW, Mezey E, Gaganpathy-Kanniappan S. Deregulation of energy Metabolism Promotes Antfibrotic Effects in Human Hepatic Stellate Cells and Prevents Liver Fibrosis in a Mouse Model. Biochem Biophys Res Comm 2016; 469(3): 463-9. PMID: 26525850
Oh Y, Park O, Swierczewska M, Hamilton JP, Park JS, Kim TH, Lim SH, Eom H, Jo DG, Lee CE, Kechrid R, Mastorakos P, Zhang C, Hahn SK, Jeon OC, Byun Y, Km K, Hanes J, Lee KC, Pomper MG, Gao B, Lee S. Systemic PEGylated TRAIL treatment ameliorates liver cirrhosis in rats by eliminating hepatic stellate cells. Hepatology 2016; 64(1): 209-23. PMID: 26710118
Honors
- Research Fellowship, NRSA
- Top Doctor, Baltimore Magazine, 1/1/20
- Top Doctor, Baltimore Magazine, 1/1/19
- Top Doctor, Baltimore Magazine, 1/1/18
Memberships
- AASLD
- AGA
Locations
- Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
- 2360 West Joppa Road, Joppa Concourse STE 205, Lutherville, MD 21093
- phone: 410-933-7495
- fax: 410-616-7351
- Johns Hopkins Outpatient Center
- 601 North Caroline Street, Floor 7, Baltimore, MD 21287
- phone: 410-933-7495
- fax: 443-287-9359
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Gastroenterology, 2007University of Maryland Medical Center
Fellowship, Gastroenterology, 2006McGaw Medical Center of Northwestern University
Residency, Internal Medicine, 2003University of Maryland School of Medicine
Medical Education, Medicine, MD, 2000Board Certifications
Transplant Hepatology
American Board of Internal Medicine, 2018Gastroenterology
American Board of Internal Medicine, 2016Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
69 ratings, 31 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 1/24/2025
Dr Hamilton is an exceptional communicator and certainly an excellent physician .I feel well taken care of with this doctor and assured with his decision making. Can't want for more than that from a doctor
- 5 out of 5 starsReviewed on 1/24/2025
The best ever
- 5 out of 5 starsReviewed on 1/22/2025
Easy to work with
- 5 out of 5 starsReviewed on 1/15/2025
This was my first visit with Dr Hamilton. He spent an hour going over my recent hospitalization, bloodwork, scans and procedures. He was very through and explained my condition in depth.
- 5 out of 5 starsReviewed on 1/8/2025
This was my first in person appointment with Dr. Hamilton, although I have been briefly in communication with him previously via the portal. He seemed very attentive and spent a lot of time eliciting information about my symptoms and past history which will hopefully lead to a diagnosis one day!
- 5 out of 5 starsReviewed on 1/8/2025
Dr Hamilton is the best
- 5 out of 5 starsReviewed on 12/11/2024
Dr.,Hamilton is extremely knowledgeable, thorough, and personable. He is the best of the best.
- 5 out of 5 starsReviewed on 11/20/2024
I enjoyed my experience.
- 5 out of 5 starsReviewed on 11/13/2024
Listened attentively, explained condition and options thoroughly, explained possible causes, discussed and settled on next steps together. Very respectful, friendly, pleasant and knowledgeable. I did not feel rushed in any way. He gave me all the time I needed with him so I left feeling very comfortable in understanding my situation and understanding the plan going forward. Also his P.A., with whom I reviewed everything with Initially was very friendly, pleasant, well informed of my situation and listened attentively.
- 5 out of 5 starsReviewed on 11/6/2024
This provider is an excellent top-notch doctor. He took extreme care to make sure I understood my health condition and spent a lot of time with me.
- 5 out of 5 starsReviewed on 11/6/2024
Dr Hamilton is EXCELLENT!! He is So KNOWLEDGEABLE VERY CARING, and is the VERY BEST DOCTOR anyone could have. He's EXCEPTIONAL.
- 5 out of 5 starsReviewed on 10/30/2024
They are the best!!
- 5 out of 5 starsReviewed on 10/16/2024
I am very lucky to have Dr. Hamilton looking after my liver condition. He is always very helpful and shows great interest in treating me. He is genuinely involved in my treatment and guiding my steps to a total cure. Very grateful for his professional advice and guidance.
- 5 out of 5 starsReviewed on 10/9/2024
Very knowledgeable doctor Explains things very simply Always prioritize your concerns and does respects and listens attentively to your concerns
- 5 out of 5 starsReviewed on 9/25/2024
Great Provider
- 5 out of 5 starsReviewed on 9/25/2024
Dr. James Hamilton is an excellent, caring, patient, physician in whom I have the utmost confidence in his professional knowledge and abilities as a doctor. He is available when necessary and listens carefully. I believe he saved my life and diagnosed a rare cancer for which I was subsequently treated at Hopkins. It has been two and a half years plus that I have been his patient and intend to remain so for a very long time even at my 74 years of age.
- 5 out of 5 starsReviewed on 9/4/2024
Lucky to have his expert advice
- 5 out of 5 starsReviewed on 9/4/2024
Very good provider.
- 5 out of 5 starsReviewed on 7/31/2024
Dr.Hamilton is one of the most excellent doctors to whom I have ever been referred (and I see many specialists at many hospitals). He listened very well, educated me about my condition, included me in the decision making. He is kind and caring, truly one of the best!
- 5 out of 5 starsReviewed on 7/31/2024
I have been patient of Dr. Hamilton for many years, he takes his time to listen, he has excellent bed manners. He is caring and tried hard to find the best solution. He is a great doctor and I am very pleased with him.
- 5 out of 5 starsReviewed on 7/24/2024
Very professional and honest.
- 5 out of 5 starsReviewed on 7/10/2024
Dr. Hamilton is a great guy. Very Personable and actually takes the time to talk and listen to my concerns. He is what I always remember doctors to be. Someone who actually cares about his patients . I wish all doctors were like him.
- 5 out of 5 starsReviewed on 5/29/2024
Great team. Even though I'm a complicated case I feel confident I'm with the right team.
- 5 out of 5 starsReviewed on 5/15/2024
Drs. Hamilton and [Staff] were both knowledgeable and caring during my visit. I appreciate that.
- 5 out of 5 starsReviewed on 5/8/2024
Dr Hamilton was awesome. Trust every word he says
- 5 out of 5 starsReviewed on 5/1/2024
Dr Hamilton is an awesome physician very well trained in his field
- 5 out of 5 starsReviewed on 4/17/2024
My consultation with Dr. Hamilton was outstanding. He described my condition fully using test results. He listened carefully to me and answered every question completely. This was the best conversation I have ever had with a doctor. His assistant was also very forthcoming and described my situation carefully. She answered every question.
- 5 out of 5 starsReviewed on 4/10/2024
I felt listened to and the provider was knowledgeable and prepared
- 5 out of 5 starsReviewed on 4/10/2024
Dr. Hamilton listened to all of my concerns and answered all my questions. I never felt rushed.
- 5 out of 5 starsReviewed on 4/10/2024
Dr Hamilton is wonderful. He takes the time to explain everything and always has time for questions. He is very caring and kind.
- 5 out of 5 starsReviewed on 3/29/2024
Dr. Hamilton is the kindest and most caring doctor I have ever worked with. He demonstrates genuine concern and goes above and beyond to make sure everything is taken care of for me. He is friendly and respectful. My whole family thinks the world of him