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Clifton Bingham III

Clifton Bingham III, MD

Rheumatology

Accepting New Patients
Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

14 Insurances Accepted

View all

Gender

Male

About Clifton Bingham III

Professional Titles

  • Director, Johns Hopkins Arthritis Center
  • Director, Center for Patient Centered Outcomes Research in Rheumatology
  • Deputy Director for Research, Division of Rheumatology
  • Co-Director, Rheumatic Diseases Research Core Center
  • Vice Chair for Clinical and Translational Research, Department of Medicine

Primary Academic Title

Professor of Medicine

Background

Dr. Clifton Bingham is a Professor of Medicine, Director of the Johns Hopkins Arthritis Center, Director of the Center for Patient-Centered Outcomes Research in Rheumatology, Deputy Director for Research in the Division of Rheumatology, and Co-Director of the Rheumatic Diseases Research Core Center. He received his M.D. from Columbia University, where he also completed his Internal Medicine residency. He trained as a Fellow in both Rheumatology and in Allergy and Clinical Immunology at the Brigham and Women’s Hospital. Before coming to Hopkins in 2005, he was on faculty at NYU Hospital for Joint Diseases, where he founded a pioneering clinical and translational research center in rheumatology. He now directs the Johns Hopkins Arthritis Center, a group of 8 rheumatologists, 2 nurses, and a large clinical and research staff that sees more than 4500 patient visits each year, an integrates research with clinical care. His clinical interests are in the care of people living with Rheumatoid Arthritis (RA) and other forms of inflammatory arthritis. 

Dr. Bingham’s research experience has been diverse, and across the research continuum from bench to bedside.  His early work focused on understanding the cytokine regulation of inflammatory mediator generation operative in rheumatologic and allergic diseases.  He conducted prior translational research to better understand the role of initiating and amplifying pathways in RA, and has ongoing collaborations with several basic researchers to identify biomarkers for improved patient phenotyping and outcome prediction. Additional multidisciplinary clinical and translational work has focused on the role of periodontal disease and oral bacteria as triggers of RA.  

In the realm of clinical research, he has served as principal investigator and helped to design and analyze a number of NIH and industry-sponsored clinical trials of multiple agents in early to late phases of development for RA, psoriatic arthritis, and osteoarthritis.  He has led several studies of the effects of biological and immunomodulatory therapies on responses to immunizations. A large amount of his current research is focused in the area of patient centered outcomes research, including patient reported outcome development, validation, and integration in clinical care. He serves as a member of the Executive Leadership Committee for the international Outcome Measures in Rheumatology (OMERACT) methodology group.

He has authored more than 170 original research articles, reviews, and editorials, and 12 book chapters. He served as a Co-Editor for the journal of the American College of Rheumatology, Arthritis and Rheumatology, and as a reviewer for a number of rheumatology journals and national and international grant reviews.  

Clinical Trial Keywords

Rheumatoid arthritis, clinical trials, outcome measures, patient-reported outcomes, psoriatic arthritis, spondyloarthritis, patient centered outcomes research

Contact for Research Inquiries

5200 Eastern Avenue
Mason F. Lord, Center Tower, Room 404
Baltimore, MD 21224

Phone: (410) 550-0578

Research Interests

Arthritis Therapeutics, Clinic Trial outcomes in Arthritis, Patient Reported Outcomes, Rheumatoid Arthritis

Lab Website

Clifton O. Bingham III Lab

  • Research in the Clifton O. Bingham III Lab focuses on defining clinical and biochemical disease phenotypes related to therapeutic responses in rheumatoid arthritis and osteoarthritis; developing rational clinical trial designs to test new treatments; improving patient-reported outcome measures; evaluating novel imaging modalities for arthritis; and examining the role of oral health in inflammatory arthritis.

Research Summary

Dr. Bingham’s current research is broadly centered on improving the assessment of patients with inflammatory arthritis through more precise disease phenotyping, spanning from biochemical characterization to measuring individual patient level disease experience and contextual factors.  This work takes advantage of an integrated clinical and research operation and infrastructure to couple investigation with clinical care.

Dr. Bingham directs a number of research projects: (1) Improving the assessment of the patient’s perspective of inflammatory arthritis through development and testing of patient reported outcome measures (e.g. PROMIS); (2) Developing and improving methods to evaluate novel immunomodulatory therapies and treatment strategies; and (3) Identifying patient subsets in inflammatory arthritis utilizing the Johns Hopkins Precision Medicine Analytical Platform (PMAP);.  Additional ongoing collaborative projects are evaluating advanced technologies and molecular diagnostics for imaging RA and OA, mechanisms and mediators of pain in arthritis, and novel bioengineered compounds and stem cells to reduce inflammation and potentially promote joint repair.

Selected Publications

  • Bartlett SJ, Bykerk VB, Cooksey R, Choy EH, Alten R, Christensen R, Furst DR, Guillemin F, Halls S,  Hewlett S, Leong AL, Lyddiatt A, March L, Monte P, Orbai AM, Pohl C, Voshaar MS, Woodworth TG, Bingham CO 3rd. Feasibility and domain validation of RA flare core domain set: A report of the OMERACT Flare working group. J Rheumatol 2015 Feb 15. pii: jrheum.141169. [Epub 2015 Feb 15] PMID: 25684764. 

     

  • Bartlett SJ, Haaz S, Mill C, Bernatsky S, Bingham CO 3rd. Yoga in rheumatic diseases.  Curr Rheumatol Rep 2013 Dec;15(12):387. (Invited Review). PMID: 24173693. 

  • Bingham CO 3rd, Alten R, DeWit MP.  The Importance of Patient Participation in Measuring Rheumatoid Arthritis Flares.  Ann Rheum Dis, 2012;71:7 1107-1109. (Invited Editorial). PMID: 22323439.

  • Bingham CO 3rd, Rizzo W, Kivitz A, Hassanali A, Upmanyu R, Klearman M. Humoral immune response to vaccines in rheumatoid arthritis patients treated with tocilizumab: results of a randomized controlled trial (VISARA). Ann Rheum Dis 2015; 74:818-822.[Epub 21 Jan 2014]. PMID: 2448345.

  • Boers M, Kirwan JR, Wells G, Beaton D, Gossec L, D’Agostino MA, Conaghan PG, Bingham CO 3rd, Brooks PB, Landewe R, March L, Simon LS, Singh JA, Strand V, Tugwell PT. Developing core outcome measurement sets for clinical trials: OMERACT Filter 2.0. J Clin Epi 2014 Jul;67(7):745-53. PMID: 24582946 

  • McMahan ZH, Bingham CO 3rd. Effects of biological and nonbiological immunomodulatory therapies on the immunogenicity of vaccines in patients with rheumatic diseases.  Arthritis Res Ther 2014; 16:506  doi:10.1186/s13075-014-0506-0. PMID: 25587634.

  • Moonaz SH, Bingham CO 3rd, Wissow L, Bartlett SJ.  Yoga in Sedentary Adults with Arthritis: Effects of a Randomized Controlled Pragmatic Trial. J Rheumatol Jul;42(7):1194-202. doi: 10.3899/jrheum.141129. Epub 2015 Apr 1. PMID: 25834206.

  • Orbai AM, Bingham CO 3rd. Patient-reported outcomes in rheumatoid arthritis.  Curr Rheumatol Rep. 2015 Apr;17(4):501. doi: 10.1007/s11926-015-0501-8. (Invited Review).PMID: 25854489.

  • Orbai AM, Smith KC, Bartlett SJ, DeLeon E, Bingham CO 3rd. “Stiffness has different meanings, I think, to everyone.” Examining stiffness from the perspective of people living with rheumatoid arthritis. Arthritis Care Res (Hoboken). 2014 Nov; 66(11):1662-72. PMID: 24891304. 

  • Timlin H, Bingham CO 3rd.  Efficacy and safety implications of molecular constructs of biological agents for rheumatoid arthritis.  Expert Opin Biol Ther 2014;14(7):893-904. (Invited Review). PMID: 24720727.

  • Winthrop KL, Silverfield J, Racewicz A, Neal J, Lee EB, Hrycaj P, Gomez-Reino J, Soma K, Riese R, Mebus C, Wilkinson B, Hodge J, Fan H, Wang T, Bingham CO 3rd.  The effect of tofacitinib on pneumococcal and influenza vaccine responses in rheumatoid arthritis.  Ann Rheum Dis 2015 March 20, doi:10.1136/ annrheumdis-2014-207191 [Epub 2015 March 20]. PMID: 5795907.

Courses & Syllabi

  • Advances in the Diagnosis and Treatment of the Rheumatic Diseases, Johns Hopkins University
  • Advancing Patient Centered Outcomes Research, Johns Hopkins University

Honors

Diplomate, American Board of Rheumatology

Lectures & Presentations

  • Engaging Stakeholder Input in a Study of Patient-Reported Outcomes in Arthritis Clinical Care, Lecture, Fostering and Assessing Patient and Stakeholder Engagement in PCORI Pilot Projects, Annual Research Meeting Panel, Academy Health, San Diego, CA, 1/1/14
  • Immunizations in Rheumatic Diseases, Lecture, Biological Therapies Summit, Cleveland Clinic, Clevland, OH, 1/1/15
  • Patient Centered Outcomes Research: IRB Centered Challenges: The Investigator's Perspective, Panel, Advancing Ethical Research Conference Panel, Public Responsibility in Medicine and Research, Baltimore, MD, 1/1/14
  • Rheumatoid Arthritis and Immunobiological Therapy, Lecture, Multidisciplinary Educational Symposium, Porto Allegre, Brasi, 1/1/15
  • Using PROMIS in PCOR: Lessons from PCORI's Pilot Projects, Lecture, Advances in Patient-Centered Outcomes Research, Inaugural Conference, PROMIS Health Organization, Philadelphia, PA, 1/1/15
  • Using PROMIS Measures in RA Clinical Care, Lecture, Inaugural Meeting, Canadian Patient Reported Outcomes Network, Montreal, Canada, 1/1/13
  • Using PROs in Rheumatology Clinical Care, Lecture, Annual Meeting, American College of Rheumatology, Boston, MA, 1/1/14

Memberships

  • American Academy of Allergy, Asthma, and Immunology, Fellow
  • American College of Rheumatology, Fellow
  • Outcome Measures in Rheumatology (OMERACT),

    Executive Committee Member

Professional Activities

  • Annals of Rheumatic Diseases, Journal Reviewer
  • Arthritis and Rheumatism/Arthritis and Rheumatology, Journal Reviewer
  • Arthritis and Rheumatology (formerly Arthritis and Rheumatism), Co-Editor
  • Arthritis Care and Research, Journal Reviewer
  • Arthritis Research and Therapy, Journal Reviewer
  • Clinical Care in the Rheumatic Diseases, Third Edition, 2006, Association of Rheumatology Health Professionals, Associate Editor, 1/1/06 - 12/31/06
  • Johns Hopkins Bayview Medical Center, Bayview Scientific Advisory Board, 1/1/07
  • Johns Hopkins Bayview Medical Center, Center for Innovative Medicine Member, 1/1/13
  • Johns Hopkins Medicine, Leadership Development Program, 1/1/11 - 12/31/11
  • Johns Hopkins School of Medicine, Taskforce for the Systematic Collection of Patient Reported Outcomes, 1/1/13
  • Journal of Clinical Rheumatology, Journal Reviewer
  • Journal of Rheumatology, Journal Reviewer
  • Nature Reviews in Rheumatology, Journal Reviewer
  • Osteoarthritis and Cartilage, Journal Reviewer
  • Rheumatology (Oxford), Journal Reviewer
  • Scandinavian Journal of Rheumatology, Journal Reviewer
  • Seminars in Arthritis and Rheumatism, Journal Reviewer

Locations

  1. Johns Hopkins Bayview Medical Center
    • 4940 Eastern Avenue, Bayview Medical Offices, Level 01 (G), Clinic 5, Baltimore, MD 21224

    Expertise

    Education

    Brigham and Women's Hospital

    Fellowship, Allergy and Clinical Immunology, 1998

    Brigham and Women's Hospital

    Fellowship, Rheumatology, 1996

    New York-Presbyterian Columbia

    Residency, Internal Medicine, 1993

    Columbia University College of Physicians and Surgeons

    Medical Education, MD, 1990

    Board Certifications

    Rheumatology

    American Board of Internal Medicine, 1996

    Insurance

    Johns Hopkins providers accept various commercial health insurance plans. However, they may not be included in all of an insurance company's plans or offerings. This may include Exchange, Medicaid, Medicare, and specific limited benefit plans. Exceptions to participation also exist based on your employer’s benefits package and the provider's location or specialty. Please contact your insurer directly to make sure your doctor is covered by your plan. For more details, please review our Insurance Information.
    Search plans
    • Aetna
    • CareFirst
    • Cigna
    • First Health
    • Geisinger Health Plan
    • HealthSmart/Accel
    • Humana
    • Johns Hopkins Health Plans
    • MultiPlan
    • Pennsylvania's Preferred Health Networks (PPHN)
    • Point Comfort Underwriters
    • Private Healthcare Systems (PHCS)
    • UnitedHealthcare
    • Veteran Affairs Community Care Network (Optum-VACCN)

    Ratings & Reviews

    5 out of 5

    99 ratings, 49 reviews

    The Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.

    Overall Rating by Patient
    Average provider Overall Rating by Patient rating 4.9 out of 5 stars
    Provider Listened Carefully
    Average provider Provider Listened Carefully rating 5 out of 5 stars
    Provider Explained Things Clearly
    Average provider Provider Explained Things Clearly rating 5 out of 5 stars
    Provider Knew Medical History
    Average provider Provider Knew Medical History rating 5 out of 5 stars
    Provider Showed Respect
    Average provider Provider Showed Respect rating 5 out of 5 stars
    Provider Spent Enough Time
    Average provider Provider Spent Enough Time rating 5 out of 5 stars
    Search reviews
      5 out of 5 stars
      Reviewed on 1/22/2025

      Dr. Bingham is excellent.

      5 out of 5 stars
      Reviewed on 1/22/2025

      Wonderful

      5 out of 5 stars
      Reviewed on 1/15/2025

      Wonderful, kind, patient.

      5 out of 5 stars
      Reviewed on 12/23/2024

      Dr Bingham is an excellent physician.. He is very smart and experienced, and I rely on his advice 150%.

      5 out of 5 stars
      Reviewed on 11/25/2024

      Very happy

      5 out of 5 stars
      Reviewed on 11/20/2024

      Pleasant, patient, and extremely kind

      5 out of 5 stars
      Reviewed on 11/6/2024

      Dr. Bingham is wonderful.

      5 out of 5 stars
      Reviewed on 11/6/2024

      When I have an Apt at Johns Hopkins I always look forward to that. It makes me happy and feel safe with Dr. Bingham has taken such good care of me.

      5 out of 5 stars
      Reviewed on 10/28/2024

      Dr. Bingham clearly cares about the outcomes for his patients. He listened to my questions and treated my concerns with respect. JH is the best in the country in RA treatment and research and Dr Bingham reflects that professionalism and competence. His confidence in the outcome is very reassuring for me, especially since it comes from such a high level of knowledge and experience.

      5 out of 5 stars
      Reviewed on 10/28/2024

      Dr. Bingham takes time to listen to his patients. He is very knowledgeable and caring.

      5 out of 5 stars
      Reviewed on 10/28/2024

      Dr Bingham was extremely knowledgeable and took the time during my exam answering any questions or concerns. I never felt rushed. I also know he is an excellent doctor.

      5 out of 5 stars
      Reviewed on 10/23/2024

      I have made, in my opinion, excellent progress with my condition (RA) and I owe it all to the care I have received from Dr Bingham. I would highly recommend him to anyone with RA.

      5 out of 5 stars
      Reviewed on 10/21/2024

      Dr. Bingham is a very nice and skillful provider to treat my health issue. I believe that he'll bring me to normal or at least to stop my issues without advancing further.

      5 out of 5 stars
      Reviewed on 10/14/2024

      I have an excellent provider, I've been seeing for years.

      5 out of 5 stars
      Reviewed on 10/7/2024

      I drive from Richmond to Baltimore only because of Dr. Bingham. Dr. Bingham isn't only the best Arthritis specialits there is, he is the most holistic medical professional I have ever experienced.

      5 out of 5 stars
      Reviewed on 9/30/2024

      Dr. Bingham takes the time to explain everything I need to know.

      5 out of 5 stars
      Reviewed on 9/30/2024

      Very professional, patient, polite, caring, provide valuable information to me to better my health.

      5 out of 5 stars
      Reviewed on 9/16/2024

      Hopkins doctors are always kind and listen to patients concerns fully

      5 out of 5 stars
      Reviewed on 9/11/2024

      I have been seeing Dr. Bingham for almost one year. He has been professional, considerate, and very helpful in working with me and the osteoarthritis I am living with.

      5 out of 5 stars
      Reviewed on 9/11/2024

      Outstanding provider

      5 out of 5 stars
      Reviewed on 8/28/2024

      Dr. Bingham is exceptional! He is a wonderful listener and wonderful at explaining medical terminology to those who don't understand on his level. His resident Dr. [ ] is very attentive, eager to learn and help his patients.

      5 out of 5 stars
      Reviewed on 8/26/2024

      Dr Bingham is an excellent doctor.

      5 out of 5 stars
      Reviewed on 8/21/2024

      Caring, listens well, explains well, very thorough and kind.

      5 out of 5 stars
      Reviewed on 7/31/2024

      Excellent as always

      5 out of 5 stars
      Reviewed on 7/24/2024

      Always provides great communication and help with questions!

      5 out of 5 stars
      Reviewed on 7/22/2024

      Just great to have a provider who helped me understand what is happening and why he's choosing the treatments.

      5 out of 5 stars
      Reviewed on 7/10/2024

      Dr. Bingham is an excellent doctor who explains things well and has a wonderful manner.

      5 out of 5 stars
      Reviewed on 7/8/2024

      Dr. Bingham, rheumatologist is an experienced doctor who can easily diagnose the patient condition, based on the reports provided by the patient and the conversation with the patient in getting the required health details.

      5 out of 5 stars
      Reviewed on 7/1/2024

      Dr. Bingham is an excellent clinician - probably the best I have ever encountered.

      5 out of 5 stars
      Reviewed on 6/24/2024

      As usual, Dr. Bingham provided excellent service and attention to my condition. I am extremely satisfied with the treatment I am receiving and the positive results I have experienced.

      5 out of 5 stars
      Reviewed on 6/19/2024

      Excellent - wouldn't want to see anyone else other than Dr. Bingham and his team

      5 out of 5 stars
      Reviewed on 6/5/2024

      I am so grateful that I am able to receive care from Dr. Bingham. It is so reassuring that he accurately assesses my condition and what treatment I might need to consider. Please don't let him ever retire.

      5 out of 5 stars
      Reviewed on 5/29/2024

      Bingham is beyond words the most extraordinary doctor I have in my life taking care of me. For over 10 years He has guided me carefully though my treatment. He is always available for questions and has the most recent research information regarding my condition. I trust h with my life.

      5 out of 5 stars
      Reviewed on 5/29/2024

      Professional, thorough, and explains things clearly.

      5 out of 5 stars
      Reviewed on 5/22/2024

      I've been seeing Dr Bingham for many years and am most grateful to be his patient. He is highly knowledgeable, and extremely responsive to our queries and questions. He is kind, and always pleasant.

      5 out of 5 stars
      Reviewed on 5/8/2024

      Outstanding care provider!

      5 out of 5 stars
      Reviewed on 5/6/2024

      Dr. Bingham is always delightful and knowledgeable!

      5 out of 5 stars
      Reviewed on 5/1/2024

      I feel very fortunate to have Dr. Bingham as my Rheumatologist.

      5 out of 5 stars
      Reviewed on 5/1/2024

      Best doctor I have ever see

      5 out of 5 stars
      Reviewed on 4/15/2024

      I have the highest regard for Dr Bingham. He always takes his time with me, explains things in a clear manner. Our appointments are always discussions and I And very fortunate that he is the doctor managing my condition. It is because of him that I am making progress.

      5 out of 5 stars
      Reviewed on 4/8/2024

      I rate Dr Bingham as the best doctor (primary or specialist) whom I have ever encountered. He displays such a perfect balance of professionalism and kindness that I feel significantly better after each visit. He gives me the confidence to manage my health challenges and takes the time to address all my concerns in a meaningful way. He is a true healer in the finest sense.

      5 out of 5 stars
      Reviewed on 4/8/2024

      Fantastic doctor

      5 out of 5 stars
      Reviewed on 4/3/2024

      Dr Bingham has been incredible in every way. I value his professionalism, impressive medical knowledge, and most important, his wise medical advice related to all aspects of my RA challenges. A 5+ in every respect.

      5 out of 5 stars
      Reviewed on 4/1/2024

      I think Dr. Bingham is an amazing doctor/Rheumatologist. I saw four before finding him. I have been seeing him for 16 years.[ ]

      5 out of 5 stars
      Reviewed on 3/27/2024

      The doctor is an excellent professional! Very grateful for your medical care and attentions

      5 out of 5 stars
      Reviewed on 3/20/2024

      Excellent physician - could not ask for a better doctor for my case. No one else had answers, but Dr. Bingham and his team are ALWAYS searching for answers and ways to help. Eternally grateful for them all.

      5 out of 5 stars
      Reviewed on 3/18/2024

      Great Communicater

      5 out of 5 stars
      Reviewed on 3/11/2024

      Dr Bingham is an excellent doctor, smart and cares. We need more like him.

      5 out of 5 stars
      Reviewed on 2/21/2024

      Dr. Bingham is the best RA doctor in the world, and I am so blessed to have him as my doctor.