
Javier Bolanos Meade, MD
Hematologic Malignancy
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Javier Bolanos Meade
Primary Academic Title
Professor of Oncology
Background
As a member of the Johns Hopkins Kimmel Cancer Center, my group's research is focused on finding novel therapies for the treatment of both acute and chronic graft versus host disease (GVHD). To that end, we are developing new strategies for prophylaxis as well as therapies for this problem. We are exploring the use of drugs such as pentostatin in steroid refractory GVHD. This drug inhibits an enzyme, called ADA, that induces apoptosis (cell death) of lymphocytes, the effector cells in GVHD. Our results using this approach have been quite encouraging. Also, we are exploring other novel approaches such as extracorporeal photopheresis or high-dose cyclophosphamide. We are participating in the NIH Bone Marrow Transplant Clinical Trials Network consortium to find useful therapies for GVHD. We are also members of the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials on Chronic GVHD, and there we are trying to establish rational guidelines for supportive care, trial design, etc. We run an internationally unique GVHD multidisciplinary clinic with many GVHD experts including a nurse practitioner, research nurse and others from fields such as physical medicine and rehabilitation, gastroenterology, ophthalmology, dermatology, pulmonology and more.
Centers and Institutes
Clinical Trial Keywords
GVHD
Research Interests
GVHD, stem cell transplantation
Selected Publications
- Bolanos-Meade, J. Update on the management of acute graft-versus-host disease. Curr Opin Oncol. 2006 Mar;18(2):120-125.
Bolanos-Meade, J.; Hartley, E.; Jones, R.J. Long-term follow-up of allogeneic marrow transplantation for acute myelogenous leukemia after treatment with busulfan and cyclophosphamide. Biol Blood Marrow Transplant. 2006 Mar;12(3):366-367.
Bolanos-Meade, J.; Vogelsang, G.B. Mesenchymal stem cells and organ transplantation: current status and promising future. Transplantation. 2006 May 27;81(10):1388-1389.
Couriel, D.; Carpenter, P.A.; Cutler, C.; Bolanos-Meade, J.; Treister, N.S.; Gea-Banacloche, J.; Shaughnessy, P.; Hymes, S.; Kim, S.; Wayne, A.S.; Chien, J.W.; Neumann, J.; Mitchell, S.; Syrjala, K.; Moravec, C.K.; Abramovitz, L.; Liebermann, J.; Berger, A.; Gerber, L.; Schubert, M.; Filipovich, A.H.; Weisdorf, D.; Schubert, M.M.; Shulman, H.; Schultz, K.; Mittelman, B.; Pavletic, S.; Vogelsang, G.B.; Martin, P.J.; Lee, S.J.; Flowers, M.E. Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol Blood Marrow Transplant. 2006 Apr;12(4):375-396.
Bolanos-Meade, J.; Anders, V.; Wisell, J.; Farmer, E.R.; Vogelsang, G.B. Grover's Disease after Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2007 Sep;13(9):1116-1117.
Bolanos-Meade, J.; Garrett-Mayer, E.; Luznik, L.; Anders, V.; Webb, J.; Fuchs, E.J.; Huff, C.A.; Matsui, W.; Borrello, I.M.; Brodsky, R.; Kasamon, Y.L.; Swinnen, L.J.; Flinn, I.W.; Ambinder, R.F.; Jones, R.J.; Hess, A.D.; Vogelsang, G.B. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant. 2007 Oct;13(10):1185-1191.
Bolanos-Meade, J.; Vogelsang, G.B. Montelukast in chronic graft-versus-host disease: a breath of fresh air Transplantation. 2007 Mar 15;83(5):527-528.
Jacobsohn, D.A.; Chen, A.R.; Zahurak, M.; Piantadosi, S.; Anders, V.; Bolanos-Meade, J.; Higman, M.; Margolis, J.; Kaup, M.; Vogelsang, G.B. Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. J Clin Oncol. 2007 Sep 20;25(27):4255-4261.
Loyo, M.; Quintanilla-Dieck Mde, L.; Stein, B.; Bolanos-Meade, J. Bilateral subdural hematoma after hematopoietic stem cell transplantation: a diagnosis often overlooked. Leuk Lymphoma. 2007 Apr;48(4):835-836.
Bolanos-Meade, J.; Vogelsang, G.B. Chronic graft-versus-host disease. Curr Pharm Des. 2008;14(20):1974-1986.
Brodsky, R.A.; Luznik, L.; Bolanos-Meade, J.; Leffell, M.S.; Jones, R.J.; Fuchs, E.J. Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant. 2008 Oct;42(8):523-527.
Luznik, L.; O'Donnell, P.V.; Symons, H.J.; Chen, A.R.; Leffell, M.S.; Zahurak, M.; Gooley, T.A.; Piantadosi, S.; Kaup, M.; Ambinder, R.F.; Huff, C.A.; Matsui, W.; Bolanos-Meade, J.; Borrello, I.; Powell, J.D.; Harrington, E.; Warnock, S.; Flowers, M.; Brodsky, R.A.; Sandmaier, B.M.; Storb, R.F.; Jones, R.J.; Fuchs, E.J. HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant. 2008 Jun;14(6):641-650.
Alousi, A.M.; Weisdorf, D.J.; Logan, B.R.; Bolanos-Meade, J.; Carter, S.; Difronzo, N.; Pasquini, M.; Goldstein, S.C.; Ho, V.T.; Hayes-Lattin, B.; Wingard, J.R.; Horowitz, M.M.; Levine, J.E. Etanercept, mycophenolate, denileukin, or pentostatin plus corticosteroids for acute graft-versus-host disease: a randomized phase 2 trial from the Blood and Marrow Transplant Clinical Trials Network. Blood. 2009 Jul 16;114(3):511-517.
Bolanos-Meade, J.; Brodsky, R.A. Blood and marrow transplantation for sickle cell disease: overcoming barriers to success. Curr Opin Oncol. 2009 Mar;21(2):158-161.
Bolanos-Meade, J.; Luznik, L.; Muth, M.; Matsui, W.H.; Huff, C.A.; Smith, B.D.; Levy, M.Y.; Kasamon, Y.L.; Swinnen, L.J.; Powell, J.D.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Salvage transplantation for allograft failure using fludarabine and alemtuzumab as conditioning regimen. Bone Marrow Transplant. 2009 Mar;43(6):477-480.
Fuchs, E.J.; Luznik, L.; Bolanos-Meade, J.; Miller, C.B.; Brodsky, R.A.; Ambinder, R.F.; Jones, R.J. Successful pregnancy and childbirth after reduced-intensity conditioning and partially HLA-mismatched BMT. Bone Marrow Transplant. 2009 Jun;43(12):969-970.
Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O'Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-Haploidentical BMT with High-Dose Posttransplantation Cyclophosphamide: Effect of HLA Disparity on Outcome. Biol Blood Marrow Transplant. 2009 Nov 16.
Kasamon, Y.L.; Wahl, R.L.; Ziessman, H.A.; Blackford, A.L.; Goodman, S.N.; Fidyk, C.A.; Rogers, K.M.; Bolanos-Meade, J.; Borowitz, M.J.; Ambinder, R.F.; Jones, R.J.; Swinnen, L.J. Phase II study of risk-adapted therapy of newly diagnosed, aggressive non-Hodgkin lymphoma based on midtreatment FDG-PET scanning. Biol Blood Marrow Transplant. 2009 Feb;15(2):242-248.
Bolanos-Meade, J.; Smith, B.D.; Gore, S.D.; McDevitt, M.A.; Luznik, L.; Fuchs, E.J.; Jones, R.J. 5-Azacytidine as Salvage Treatment in Relapsed Myeloid Tumors after Allogeneic Bone Marrow Transplantation. Biol Blood Marrow Transplant. 2010 Oct 15;In Press.
Karp, J.E.; Blackford, A.; Smith, B.D.; Alino, K.; Seung, A.H.; Bolanos-Meade, J.; Greer, J.M.; Carraway, H.E.; Gore, S.D.; Jones, R.J.; Levis, M.J.; McDevitt, M.A.; Doyle, L.A.; Wright, J.J. Clinical activity of sequential flavopiridol, cytosine arabinoside, and mitoxantrone for adults with newly diagnosed, poor-risk acute myelogenous leukemia. Leuk Res. 2010 Jul;34(7):877-882.
Kasamon, Y.L.; Luznik, L.; Leffell, M.S.; Kowalski, J.; Tsai, H.L.; Bolanos-Meade, J.; Morris, L.E.; Crilley, P.A.; O'Donnell, P.V.; Rossiter, N.; Huff, C.A.; Brodsky, R.A.; Matsui, W.H.; Swinnen, L.J.; Borrello, I.; Powell, J.D.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. Nonmyeloablative HLA-haploidentical bone marrow transplantation with high-dose posttransplantation cyclophosphamide: effect of HLA disparity on outcome. Biol Blood Marrow Transplant. 2010 Apr;16(4):482-489.
Luznik, L.; Bolanos-Meade, J.; Zahurak, M.; Chen, A.R.; Smith, B.D.; Brodsky, R.; Huff, C.A.; Borrello, I.; Matsui, W.; Powell, J.D.; Kasamon, Y.; Goodman, S.N.; Hess, A.; Levitsky, H.I.; Ambinder, R.F.; Jones, R.J.; Fuchs, E.J. High-dose cyclophosphamide as single-agent, short-course prophylaxis of graft-versus-host disease. Blood. 2010 Apr 22;115(16):3224-3230.
Bolanos-Meade, J., and Vogelsang, G.B. (2008). Chronic graft-versus-host disease. Curr Pharm Des 14, 1974-1986.
Brodsky, R.A., Luznik, L., Bolanos-Meade, J., Leffell, M.S., Jones, R.J., and Fuchs, E.J. (2008). Reduced intensity HLA-haploidentical BMT with post transplantation cyclophosphamide in nonmalignant hematologic diseases. Bone Marrow Transplant 42, 523-527.
Luznik, L., O''Donnell, P.V., Symons, H.J., Chen, A.R., Leffell, M.S., Zahurak, M., Gooley, T.A., Piantadosi, S., Kaup, M., Ambinder, R.F., Huff, C.A., Matsui, W., Bolanos-Meade, J., Borrello, I., Powell, J.D., Harrington, E., Warnock, S., Flowers, M., Brodsky, R.A., Sandmaier, B.M., Storb, R.F., Jones, R.J., and Fuchs, E.J. (2008). HLA-haploidentical bone marrow transplantation for hematologic malignancies using nonmyeloablative conditioning and high-dose, posttransplantation cyclophosphamide. Biol Blood Marrow Transplant 14, 641-650.
Bolanos-Meade, J., and G. B. Vogelsang. 2007. Montelukast in chronic graft-versus-host disease: a breath of fresh air? Transplantation 83:527-8.
Bolanos-Meade, J., E. Garrett-Mayer, L. Luznik, V. Anders, J. Webb, E. J. Fuchs, C. A. Huff, W. Matsui, I. M. Borrello, R. Brodsky, Y. L. Kasamon, L. J. Swinnen, I. W. Flinn, R. F. Ambinder, R. J. Jones, A. D. Hess, and G. B. Vogelsang. 2007. Induction of autologous graft-versus-host disease: results of a randomized prospective clinical trial in patients with poor risk lymphoma. Biol Blood Marrow Transplant 13:1185-91.
Bolanos-Meade, J., V. Anders, J. Wisell, E. R. Farmer, and G. B. Vogelsang. 2007. Grover''s Disease after Bone Marrow Transplantation. Biol Blood Marrow Transplant 13:1116-7.
Jacobsohn, D. A., A. R. Chen, M. Zahurak, S. Piantadosi, V. Anders, J. Bolanos-Meade, M. Higman, J. Margolis, M. Kaup, and G. B. Vogelsang. 2007. Phase II study of pentostatin in patients with corticosteroid-refractory chronic graft-versus-host disease. J Clin Oncol 25:4255-61.
Loyo, M., L. Quintanilla-Dieck Mde, B. Stein, and J. Bolanos-Meade. 2007. Bilateral subdural hematoma after hematopoietic stem cell transplantation: a diagnosis often overlooked. Leuk Lymphoma 48:835-6.
Bolanos-Meade, J. & Vogelsang, G. B. (2006). Mesenchymal stem cells and organ transplantation: current status and promising future. Transplantation 81, 1388-9.
Bolanos-Meade, J. (2006). Update on the management of acute graft-versus-host disease. Curr Opin Oncol 18, 120-5.
Bolanos-Meade, J., Hartley, E. & Jones, R. J. (2006). Long-term follow-up of allogeneic marrow transplantation for acute myelogenous leukemia after treatment with busulfan and cyclophosphamide. Biol Blood Marrow Transplant 12, 366-7.
Couriel, D., Carpenter, P. A., Cutler, C., Bolanos-Meade, J., Treister, N. S., Gea-Banacloche, J., Shaughnessy, P., Hymes, S., Kim, S., Wayne, A. S., Chien, J. W., Neumann, J., Mitchell, S., Syrjala, K., Moravec, C. K., Abramovitz, L., Liebermann, J., Berger, A., Gerber, L., Schubert, M., Filipovich, A. H., Weisdorf, D., Schubert, M. M., Shulman, H., Schultz, K., Mittelman, B., Pavletic, S., Vogelsang, G. B., Martin, P. J., Lee, S. J. & Flowers, M. E. (2006).
Ancillary therapy and supportive care of chronic graft-versus-host disease: national institutes of health consensus development project on criteria for clinical trials in chronic Graft-versus-host disease: V. Ancillary Therapy and Supportive Care Working Group Report. Biol Blood Marrow Transplant 12, 375-96.
Bolaos-Meade, J., Zhou, L., Hoke, A., Corse, A., Vogelsang, G.,Wagner, K. R. In press. Hydroxychloroquine causes a severe vacuolar myopathy in a patient with chronic graft-versus-host disease. Am J Hematol.
Bolaos-Meade, J., Ioffe, O., Hey, J., Vogelsang, G. B., Akpek, G. In press. Lymphocytic pneumonitis as the manifestation of acute graft-versus-host disease of the lung. Am J Hematol.
Bolaos-Meade, J., Jacobsohn, D. A., Margolis, J., Ogden, A., Wientjes, M. G., Byrd, J. C., Lucas, D. M., Anders, V., Phelps, M., Grever, M. R., Vogelsang, G. B. In press. Pentostatin in steroid refractory acute graft-versus-host disease. J Clin Oncol.
Locations
- Sidney Kimmel Comprehensive Cancer Center
- 401 North Broadway Street, Weinberg BLDG, Baltimore, MD 21287
- phone: 410-955-8964
- fax: 410-367-2194
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, 2003University of Maryland Medical Center
Fellowship, Hematology and Oncology, 2002Texas Tech University Health Sciences Center
Residency, Internal Medicine, 1999Escuela de Medicina - Ignacio A Santos
Medical Education, MD, 1995Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
5 out of 5
35 ratings, 15 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 2/20/2025
The doctor was very courteous, even going as far as listening intently to my medical history and related comments.
- 5 out of 5 starsReviewed on 1/16/2025
Excellent top shelf
- 5 out of 5 starsReviewed on 1/16/2025
I was very impressed with Dr Meade. His demeanor gave me comfort. His knowledge and experience was evident. He seemed very humane and understood very well my position as a patient with this dreadful illness.
- 5 out of 5 starsReviewed on 1/10/2025
Dr Meade is a very compassionate thorough doctor who I believe hears my concerns.
- 5 out of 5 starsReviewed on 12/19/2024
Dr. Meade is very thorough, takes the time to answer all our questions, and shows real concern. Thank you!
- 5 out of 5 starsReviewed on 11/7/2024
They were kind and helpful to me.
- 5 out of 5 starsReviewed on 11/1/2024
Appreciate Dr.Meade for assisting me on my journey.
- 5 out of 5 starsReviewed on 10/25/2024
Very thorough. Good listener, allows me to participate in care decisions
- 5 out of 5 starsReviewed on 8/29/2024
Top Notch! Best Oncologist you could have!!!
- 5 out of 5 starsReviewed on 8/1/2024
Felt secure because of his honesty. He explained the process in detail, even though there would be an unpleasant time.
- 5 out of 5 starsReviewed on 7/25/2024
Dr Javier Meade was my bone marrow transplant doctor . I received my transplant for AML on [ ] 2022 . This was my 2 year recheck. I feel blessed that he was my doctor at Hopkins!
- 5 out of 5 starsReviewed on 6/13/2024
Dr. Bolaos is very good and you can tell that he has enough experience in his field
- 5 out of 5 starsReviewed on 4/22/2024
Knowledgeable. Personable
- 5 out of 5 starsReviewed on 4/19/2024
Dr JAVIER BOLANOS MEADE is an excellent, well-informed physician that explains complicated treatment in an easy to understand manner
- 5 out of 5 starsReviewed on 3/28/2024
He is the best in gvhd