Christine Hann, MD, PhD
Medical Oncology
- Johns Hopkins School of Medicine Faculty
About Christine Hann
Primary Academic Title
Associate Professor of Oncology
Background
Christine L Hann, completed her MD and Ph.D. at Jefferson Medical College/Thomas Jefferson University follwed by an internal medicine residency at the University of Chicago Hospitals. Following a fellowship at Johns Hopkins University in Hematology and Oncology, Dr. Hann joined the Johns Hopkins Sidney Kimmel Comprehensive Cancer Center as a member of the Upper Aerodigestive Cancer Program and sees patients with non-small cell and small cell lung cancer.
Dr. Hann's research focus is on developing novel therapeutics for lung cancer, particularly small cell lung cancer (SCLC) and neuroendocrine tumors (NETs) such as carcinoid tumors of the lung. As a faculty member she is involved in both clinical and laboratory research.
Specific research projects include:
1) Studying mechanisms of resistant to small molecule inhibitors of the antiapoptotic protein, BCL-2 using patient-derived xenograft models. Her preclinical work has led to an NCI-sponsored Phase 1/2 clinical trial combining a BCL-2 inhibitor with a TORC1/2 inhibitors which is currently underway (NCT03366103).
2) Preclinical evaluation of various therapeutics including epigenetic modulators (LSD1 inhibitors) and nanoliposome chemotherapy in SCLC PDXs;
3) Modeling and characterizing chemoradiotherapy resistance in preclinical models of SCLC. She, along with Dr. Luigi Marchionni in Biostatistics and Dr. Phuoc Tran in the Department of Radiation Oncology, were recently awarded a 5-year NCI-sponsored U01 grant to study mechanisms of chemoradiation resistance in SCLC.
Dr. Hann is PI of several trials in SCLC and NSCLC and is leading investigator-initiated clinical trials in SCLC and NETs.
Centers and Institutes
Clinical Trial Keywords
lung cancer
Videos
Research Interests
New drug development for lung cancer, Small cell and non-small cell lung cancer
Selected Publications
Belani CP, Dahlberg SE, Rudin CM, Fleisher M, Chen HX, Takebe N, Velasco MR Jr, Tester WJ, Sturtz K, Hann CL, Shanks JC, Monga M, Ramalingam SS, Schiller JH. Vismodegib or cixutumumab in combination with standard chemotherapy for patients with extensive-stage small cell lung cancer: A trial of the ECOG-ACRIN Cancer Research Group (E1508). Cancer. 2016 May 10. doi: 10.1002/cncr.30062. [Epub ahead of print] PMID: 27163943
Bunn PA Jr, Minna JD, Augustyn A, Gazdar AF, Ouadah Y, Krasnow MA, Berns A, Brambilla E, Rekhtman N, Massion PP, Niederst M, Peifer M, Yokota J, Govindan R, Poirier JT, Byers LA, Wynes MW, McFadden DG, MacPherson D, Hann CL, Farago AF, Dive C, Teicher BA, Peacock CD, Johnson JE, Cobb MH, Wendel HG, Spigel D, Sage J, Yang P, Pietanza MC, Krug LM, Heymach J, Ujhazy P, Zhou C, Goto K, Dowlati A, Christensen CL, Park K, Einhorn LH, Edelman MJ, Giaccone G, Gerber DE, Salgia R, Owonikoko T, Malik S, Karachaliou N, Gandara DR, Slotman BJ, Blackhall F, Goss G, Thomas R, Rudin CM, Hirsch FR. Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes? J Thorac Oncol. 2016 Apr;11(4):453-74. doi: 10.1016/j.jtho.2016.01.012. Epub 2016 Jan 30. Review. No abstract available. PMID: 26829312
MacDiarmid JA, Langova V, Bailey D, Pattison ST, Pattison SL, Christensen N, Armstrong LR, Brahmbhatt VN, Smolarczyk K, Harrison MT, Costa M, Mugridge NB, Sedliarou I, Grimes NA, Kiss DL, Stillman B, Hann CL, Gallia GL, Graham RM, Brahmbhatt H. Targeted Doxorubicin Delivery to Brain Tumors via Minicells: Proof of Principle Using Dogs with Spontaneously Occurring Tumors as a Model. PLoS One. 2016 Apr 6;11(4):e0151832. doi: 10.1371/journal.pone.0151832. eCollection 2016. PMID: 27050167
Rudin CM, Ismaila N, Hann CL, Malhotra N, Movsas B, Norris K, Pietanza MC, Ramalingam SS, Turrisi AT 3rd, Giaccone G. Treatment of Small-Cell Lung Cancer: American Society of Clinical Oncology Endorsement of the American College of Chest Physicians Guideline. J Clin Oncol. 2015 Dec 1;33(34):4106-11. doi: 10.1200/JCO.2015.63.7918. Epub 2015 Sep 8. PMID: 26351333
Sun H, Luo L, Lal B, Ma X, Chen L, Hann CL, Fulton AM, Leahy DJ, Laterra J, Li M. A monoclonal antibody against KCNK9 K(+) channel extracellular domain inhibits tumour growth and metastasis. Nat Commun. 2016 Feb 4;7:10339. doi: 10.1038/ncomms10339. PMID: 26842342
Honors
- Young Clinical Scientist Award, Flight Attendant Medical Research Institute, 1/1/07
- Pearl M. Stetler Fellowship Award for Women Physicians, Johns Hopkins University, 1/1/06
- Young Investigator Award, American Society of Clinical Oncology, 1/1/05
Memberships
- American Association for Cancer Research
- American Society of Clinical Oncology
- International Association for the Study of Lung Cancer
Locations
- Johns Hopkins Bayview Medical Center
- 300 Mason Lord Drive, Kimmel Cancer Center, Baltimore, MD 21224
- phone: 410-550-1711
- fax: 410-550-1116
- Johns Hopkins Health Care & Surgery Center - Green Spring Station, Lutherville
- 10803 Falls Road, Pavilion III STE 1500, Lutherville, MD 21093
- phone: 410-583-2970
- fax: 410-583-2980
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Hematology and Oncology, 2007The University of Chicago Medical Center
Residency, Internal Medicine, 2002Sidney Kimmel Medical College
Medical Education, Biochemistry and Molecular Biology, MD PhD, 2000Board Certifications
Medical Oncology
American Board of Internal Medicine, 2006Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)
Ratings & Reviews
4.9 out of 5
52 ratings, 23 reviewsThe Patient Rating score is an average of all responses to physician related questions on the national CG-CAHPS Medical Practice patient experience survey through Press Ganey. Responses are measured on a scale of 1 to 5, with 5 being the best score. Comments are also gathered from our CG-CAHPS Medical Practice Survey through Press Ganey and displayed in their entirety. Patients are de-identified for confidentiality and patient privacy.
- 5 out of 5 starsReviewed on 12/9/2024
Listens to my questions and answers appropriately
- 5 out of 5 starsReviewed on 11/4/2024
Very knowledgeable, personable, good listener, provides clear explanations
- 5 out of 5 starsReviewed on 11/4/2024
Excellent!!
- 5 out of 5 starsReviewed on 10/21/2024
Dr. Hann is thorough and caring about my health and family. She is interested in my opinion.
- 5 out of 5 starsReviewed on 10/14/2024
Very caring and knowledgeable. Buts you at ease.
- 5 out of 5 starsReviewed on 10/14/2024
Dr.Hann is so caring and professional, talking plainly about my lung cancer. She helps me understand my care.
- 5 out of 5 starsReviewed on 10/3/2024
Excellent.
- 5 out of 5 starsReviewed on 9/9/2024
Very good nice
- 5 out of 5 starsReviewed on 9/9/2024
Dr. Hann is very concerned about her patients health.
- 5 out of 5 starsReviewed on 8/22/2024
Dr. Hann is a blessing.
- 5 out of 5 starsReviewed on 8/15/2024
Dr. Hann is extremely knowledgeable, spent an extraordinary amount of time with us patiently explaining in a level of detail that we could understand. She provided us with confidence that treatment protocols were the best possible and was able to provide a deep dive into how's, whys and way forward. She was able to explain in a straightforward manor that cut out a lot of unnecessary noise or meandering.
- 5 out of 5 starsReviewed on 7/22/2024
As all ways Dr Hann was happy for me that my scan shows stable condition. She is a caring person and I'm happy to be treated by her.
- 5 out of 5 starsReviewed on 7/15/2024
Caring a d professional. Provided information regarding my visit in terms I could understand made sure if I had any questions she would answer
- 5 out of 5 starsReviewed on 5/23/2024
Very good
- 5 out of 5 starsReviewed on 5/13/2024
Dr.Hann was very attentive and handled all of my issues like I was her only patient .She expressed empathy and concern as well as her wealth of knowledge.
- 5 out of 5 starsReviewed on 4/15/2024
She cared and took the time to explain things
- 5 out of 5 starsReviewed on 4/8/2024
I love Dr Hann. She is a stupendous doctor and I don't think I would be here without her care!
- 5 out of 5 starsReviewed on 4/1/2024
Dr Hann was very professional, not in a cold uncaring way, but very compassionate. She treated you as a human and not just a number. Her compassion and empathy meant so very much. Dr Hann took care of my sister, and the way she took care of her meant everything to the family. I could go on, but I think in a few words I was extremely grateful for the care I received.
- 5 out of 5 starsReviewed on 3/25/2024
Dr. Hann understands my disease and is able to treat it accordingly
- 5 out of 5 starsReviewed on 3/25/2024
Dr. Hann is very caring provider. If an issue arises she addresses it immediately.
- 4 out of 5 starsReviewed on 3/4/2024
She is very professional
- 5 out of 5 starsReviewed on 2/26/2024
I was meeting with Dr. Hann for a possible Clinical trial. She is very knowledgable and understanding and I look forward to having her guide me with my trial plan
- 5 out of 5 starsReviewed on 2/26/2024
Dr Hann is the most caring and kind person.