Nadia Hansel, MD

Professional Titles

• Director, Department of Medicine
• Physician-in Chief, Johns Hopkins Hospital
• William Osler Professor of Medicine

Primary Academic Title

Professor of Medicine

Background

Centers and Institutes

• Adolescent Health, Center for
• Heart and Vascular Institute
• Innovative Medicine, Center for

Clinical Trials Summary

Dr. Hansel is participating in the LIBERATE clinical study for individuals who have difficulty breathing and suffer from severe emphysema. For more information, visit here

Contact for Research Inquiries

5501 Hopkins Bayview Circle
Baltimore, MD 21224

Research Interests

Genetic and environmental determinants of obstructive airway diseases

Lab Website

Nadia Hansel Lab

• Research in the Nadia Hansel Lab investigates the clinical, pathophysiologic and public health aspects of pulmonary diseases, with a focus on asthma and chronic obstructive pulmonary disease (COPD). We have explored how environmental exposures, nutrition and diet, comorbidity and other factors influence the outcomes of diseases such as asthma and COPD.

Research Summary

Dr. Hansel’s research focuses on understanding the determinants of health outcomes in obstructive airway diseases, including asthma and chronic obstructive pulmonary disease (COPD). In particular, she has focused on understanding the adverse health effects of low-level air pollution in homes of patients with chronic lung diseases. She is director of the Bridging Research, Lung Health & Environment (BREATHE) Center, and her work has been instrumental in showing that substantially lower pollutant concentrations found in homes not using biomass in developed countries are still an important contributor to respiratory symptoms in patients with chronic lung disease, such as COPD. In addition, her work focuses on identifying subgroups with increased susceptibility to pollution exposure and her work has also focuses on understanding clinical phenotypes of obstructive airway diseases. Understanding different factors, including environmental exposures, that may modify disease expression is critical to accurately targeting personalized disease management approaches.

PubMed

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/46597947/?sort=date&direction=

Selected Publications

• Bose S, Breysse PN, McCormack MC, Hansel NN, Rusher RR, Matsui E, Peng R, Curtin-Brosnan J, Diette GB. Outdoor exposure and vitamin D levels in urban children with asthma. Nutr J. 2013 Jun 12;12(1):81. [Epub ahead of print] PMID: 23758744 

• Burkart KM, Manichaikul A, Wilk JB, Ahmed FS, Burke GL, Enright P, Hansel NN, Haynes D, Heckbert SR, Hoffman EA, Kaufman JD, Kurai J, Loehr L, London SJ, Meng Y, O'Connor GT, Oelsner E, Petrini M, Pottinger TD, Powell CA, Redline S, Rotter JI, Smith LJ, Artigas MS, Tobin MD, Tsai MY, Watson K, White W, Young TR, Rich SS, Barr RG. APOM and high-density lipoprotein are associated with lung function and percent emphysema. Eur Respir J. 2013 Jul 30. [Epub ahead of print] PMID: 23900982 

• Himes BE, Qiu W, Klanderman B, Ziniti J, Senter-Sylvia J, Szefler SJ, Lemanske RF Jr, Zeiger RS, Strunk RC, Martinez FD, Boushey H, Chinchilli VM, Israel E, Mauger D, Koppelman GH, Nieuwenhuis MA, Postma DS, Vonk JM, Rafaels N, Hansel NN, Barnes K, Raby B, Tantisira KG, Weiss ST. ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. BMC Med Genet. 2013 Aug 28;14:86. doi: 10.1186/1471-2350-14-86. PMID: 23984888

• Jamieson DB, Matsui EC, Belli A, McCormack MC, Peng E, Pierre-Louis S, Curtin-Brosnan J, Breysse PN, Diette GB, Hansel NN. Effects of allergic phenotype on respiratory symptoms and exacerbations in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013 Jul 15;188(2):187-92. doi: 10.1164/rccm.201211-2103OC. PMID: 23668455

• Kolahdooz F, Butler JL, Christiansen K, Diette GB, Breysse PN, Hansel NN, McCormack MC, Sheehy T, Gittelsohn J, Sharma S. “Food and nutrient intake in African American children and adolescents aged 5 to 16 years in Baltimore City.” J Am Coll Nutr. 2015 Apr 9:1-12. [Epub ahead of print]

• Matsui EC, Hansel NN, Aloe C, Schiltz AM, Peng RD, Rabinovitch N, Ong MJ, Williams DL, Breysse PN, Diette GB, Liu AH. Indoor pollutant exposures modify the effect of airborne endotoxin on asthma in urban children. Am J Respir Crit Care Med. 2013 Nov 15;188(10):1210-5. doi: 10.1164/rccm.201305-0889OC. PMID: 24066676

• Paulin LM, Diette GB, Scott M, McCormack MC, Matsui EC, Curtin-Brosnan J, Williams DL, Kidd-Taylor A, Shea M, Breysse PN, Hansel NN. Home interventions are effective at decreasing indoor nitrogen dioxide concentrations. Indoor Air. 2013 Dec 14. doi: 10.1111/ina.12085. [Epub ahead of print] PMID: 24329966 

• Putcha N, Drummond MB, Connett JE, Scanlon PD, Tashkin DP, Hansel NN, Wise RA. Chronic Productive Cough is Associated with Death in Smokers with Early COPD. COPD. 2013 Oct 15. [Epub ahead of print] PMID: 24127996

• Putcha N, Drummond MB, Wise RA, Hansel NN. “Comorbidities and chronic obstructive pulmonary disease: prevalence, influence on outcomes, and management.” Semin Respir Crit Care Med. 2015 Aug;36(4):575-91. doi: 10.1055/s-0035-1556063. Epub 2015 Aug 3.

• Putcha N, Han MK, Martinez CH, Foreman MG, Anzueto AR, Casaburi R, Cho MH, Hanania NA, Hersh CP, Kinney GL, Make BJ, Steiner RM, Lutz SM, Thomashow BM, Williams AA, Bhatt SP, Beaty TH, Bowler RP, Ramsdell JW, Curtis JL, Everett D, Hokanson JE, Lynch DA, Sutherland ER, Silverman EK, Crapo JD, Wise RA, Regan EA, Hansel NN; the COPDGene® Investigators. “Comorbidities of COPD have a major impact on clinical outcomes, particularly in African Americans.” Chronic Obstr Pulm Dis (Miami). 2014;1(1):105-114.

• Putcha N, Puhan MA, Hansel NN, Drummond MB, Boyd CM. Impact of co-morbidities on self-rated health in self-reported COPD: an analysis of NHANES 2001-2008. COPD. 2013 Jun;10(3):324-32. doi: 10.3109/15412555.2012.744963. PMID: 23713595

• Rice JL, Romero KM, Galvez Davila RM, Meza CT, Bilderback A, Williams DL, Breysse PN, Bose S, Checkley W, Hansel NN; GASP Study Investigators. “Association between adherence to the Mediterranean diet and asthma in Peruvian children.” Lung. 2015 Sep 3. [Epub ahead of print]

• Romero KM, Robinson CL, Baumann LM, Gilman RH, Hamilton RG, Hansel NN, Checkley W; PURA Study Investigators. Role of exhaled nitric oxide as a predictor of atopy. Respir Res. 2013 May 2;14:48. doi: 10.1186/1465-9921-14-48. PMID: 23639047

• Stephens SH, Hartz SM, Hoft NR, Saccone NL, Corley RC, Hewitt JK, Hopfer CJ, Breslau N, Coon H, Chen X, Ducci F, Dueker N, Franceschini N, Frank J, Han Y, Hansel NN, Jiang C, Korhonen T, Lind PA, Liu J, Lyytikäinen LP, Michel M, Shaffer JR, Short SE, Sun J, Teumer A, Thompson JR, Vogelzangs N, Vink JM, Wenzlaff A, Wheeler W, Yang BZ, Aggen SH, Balmforth AJ, Baumeister SE, Beaty TH, Benjamin DJ, Bergen AW, Broms U, Cesarini D, Chatterjee N, Chen J, Cheng YC, Cichon S, Couper D, Cucca F, Dick D, Foroud T, Furberg H, Giegling I, Gillespie NA, Gu F, Hall AS, Hällfors J, Han S, Hartmann AM, Heikkilä K, Hickie IB, Hottenga JJ, Jousilahti P, Kaakinen M, Kähönen M, Koellinger PD, Kittner S, Konte B, Landi MT, Laatikainen T, Leppert M, Levy SM, Mathias RA, McNeil DW, Medland SE, Montgomery GW, Murray T, Nauck M, North KE, Paré PD, Pergadia M, Ruczinski I, Salomaa V, Viikari J, Willemsen G, Barnes KC, Boerwinkle E, Boomsma DI, Caporaso N, Edenberg HJ, Francks C, Gelernter J, Grabe HJ, Hops H, Jarvelin MR, Johannesson M, Kendler KS, Lehtimäki T, Magnusson PK, Marazita ML, Marchini J, Mitchell BD, Nöthen MM, Penninx BW, Raitakari O, Rietschel M, Rujescu D, Samani NJ, Schwartz AG, Shete S, Spitz M, Swan GE, Völzke H, Veijola J, Wei Q, Amos C, Cannon DS, Grucza R, Hatsukami D, Heath A, Johnson EO, Kaprio J, Madden P, Martin NG, Stevens VL, Weiss RB, Kraft P, Bierut LJ, Ehringer MA. Distinct Loci in the CHRNA5/CHRNA3/CHRNB4 Gene Cluster Are Associated With Onset of Regular Smoking. Genet Epidemiol. 2013 Dec;37(8):846-59. doi: 10.1002/gepi.21760. Epub 2013 Nov 1. PMID: 24186853

• Tomaino K, Romero KM, Robinson CL, Baumann LM, Hansel NN, Pollard SL, Gilman RH, Mougey E, Lima JJ, Checkley W; PURA study investigators. “Association between serum 25-hydroxy vitamin D levels and blood pressure among adolescents in two resource-limited settings in Peru.” Am J Hypertens. 2015 Aug;28(8):1017-23. doi: 10.1093/ajh/hpu264. Epub 2015 Jan 19.

Professional Activities

• Johns Hopkins, Task Force on Women's Academic Careers in Medicine, 1/1/12 - 1/1/13
• Johns Hopkins Bayview, High Risk Review Committee
• Johns Hopkins Center for Innovative Medicine, Advisory Committee