Thomas William Sedlak, MD, PhD

Professional Titles

• Director, Schizophrenia and Psychosis Consult Clinic

Primary Academic Title

Assistant Professor of Psychiatry and Behavioral Sciences

Centers and Institutes

• Molecular Psychiatry Program
• Schizophrenia Center

Lab Website

Thomas Sedlak Lab - Lab Website

Research Summary

Our laboratory studies brain metabolic and antioxidant pathways relevant to normal brain biology and neuropsychiatric conditions such as schizophrenia and Alzheimer’s disease.

PubMed

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/51265625/?sort=date&direction=descending

Selected Publications

• Koga, M., Serritella, A.V., Sawa, A., and Sedlak, T.W. (2016). Implications for reactive oxygen species in schizophrenia pathogenesis. Schizophr Res 176, 52-71

• Saito, A., Taniguchi, Y., Rannals, M.D., Merfeld, E.B., Ballinger, M.D., Koga, M., Ohtani, Y., Gurley, D.A., Sedlak, T.W., Cross, A., et al. (2016). Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1. Mol Psychiatry 21, 1449-1459

• Sawa, A., and Sedlak, T.W. (2016). Oxidative stress and inflammation in schizophrenia.  Schizophr Res 176, 1-2

• Sedlak, T.W., and Kaplin, A.I. (2016). Novel Neurotransmitters 2016. In Kaplan & Sadock's Comprehensive Textbook of Psychiatry, B.J. Sadock, V.A. Sadock, P. Ruiz, and H.I. Kaplan, eds. (Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins)

• Shahani, N., Seshadri, S., Jaaro-Peled, H., Ishizuka, K., Hirota-Tsuyada, Y., Wang, Q., Koga, M., Sedlak, T.W., Korth, C., Brandon, N.J., et al. (2015). DISC1 regulates trafficking and processing of APP and Abeta generation  Mol Psychiatry 20, 874-879