John J. Laterra, MD

Professional Titles

• Co-Director, Brain Cancer Disease Group, Sidney Kimmel Comprehensive Cancer Center
• Director, Division of Neuro-Oncology

Primary Academic Title

Professor of Neurology

Background

Centers and Institutes

• Comprehensive Brain Tumor Center
• Sidney Kimmel Comprehensive Cancer Center
• Von Hippel-Lindau Clinical Care Center

Videos

• Brain Tumor Treatment Advances Over 10 Years: Carlos' Story

Additional Academic Titles

Professor of Neuroscience, Professor of Oncology

Research Interests

Mechanisms of Brain Cancer Stem Cell Regulation

PubMed

http://www.ncbi.nlm.nih.gov/pubmed/?term=laterra%2C+john

Selected Publications

• Abounader R, Ranganathan S, Lal B, Fielding K, Book A, Dietz H, Burger P and Laterra J: Reversion of human glioblastoma malignancy by U1snRNA/ribozyme targeting of scatter factor/hepatocyte growth factor and c-met gene expression.  J Natl Cancer Inst, 91:1548-1556, 1999. PMID: 10491431.

• Kim KJ, Wang L, Su, YC, Gillespie GY, Salhotra A, Lal B and Laterra J.  Systemic anti-hepatocyte growth factor monoclonal antibody therapy induces the regression of intracranial glioma xenografts. Clin Cancer Res, 12(4):1292-1298, 2006. PMID: 16489086

• Li Y, Li A, Glas M, Lal B, Ying M, Sang Y, Xia S, Trageser D, Guerrero-Cázares H, Eberhart CG, Quiñones-Hinojosa A, Scheffler B, Laterra J: c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci U S A. 108:9951-6, 2011. PMID: 21628563; PMCID:  PMC3116406.

• Lopez-Bertoni H, Lal B, Michelson H, Guerrero-Cázares H, Quiñones-Hinojosa A, Li Y, Laterra J. Epigenetic modulation of a miR-296-5p:HMGA1 axis regulates Sox2 expression and glioblastoma stem cells. Oncogene, 2016 Feb 22. doi: 10.1038/onc.2016.22. [Epub ahead of print].

• Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R, Yan K, Wang S, Fu D-X, Blakeley J, Ford E, Tyler B, Laterra J, and van Zijl PCM:  Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Med.2011 Jan; 17(1): 130-4.  Epub Dec 19 2010.  PMID:  21170048, PMCID:  PMC3058561.

Honors

Alpha Omega Alpha

Memberships

• Journal of Neuro-Oncology,

  Associate Editor

• Scientific Advisory Board of the American Brain Tumor Association
• The Society of Neuro-Oncology, Charter Member