Winston Timp, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Winston Timp
Background
Dr. Winston Timp is an associate professor of biomedical engineering at the Whiting School of Engineering and the Johns Hopkins School of Medicine. His research focuses on sequencing technology development.
His lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Timp’s research integrates the principles of biophysics, molecular biology, and computational biology to create new tools for exploring the epigenomes and genomes of different lifeforms, ranging in size from the flu virus to hummingbirds to California redwoods. Based on the knowledge gained from these studies, Timp and his lab apply their toolsets to clinical samples for the diagnosis, surveillance, and treatment of human disease. Recent projects in Timp’s lab include new sequencing methods to diagnose infectious disease, new methods to characterize RNA biology, and examining single molecule epigenetics of cancer.
Centers and Institutes
Additional Academic Titles
Joint Appointment in Molecular Biology and Genetics, Joint Appointment in Genetic Medicine, Joint Appointment in Medicine
Contact for Research Inquiries
Phone: (410) 417-8467
Research Summary
The Timp lab’s focus is on the development and application of sequencing technologies to gain a deeper understanding of biology and a more accurate set of clinical tools for human disease. Timp’s research integrates the principles of biophysics, molecular biology, and computational biology to create new tools for exploring the epigenomes and genomes of different lifeforms, ranging in size from the flu virus to hummingbirds to California redwoods. Based on the knowledge gained from these studies, Timp and his lab apply their toolsets to clinical samples for the diagnosis, surveillance and treatment of human disease. Recent projects in Timp’s lab include new sequencing methods to diagnose infectious disease, new methods to characterize RNA biology, and examining single molecule epigenetics of cancer.
Selected Publications
I. Lee, R. Razaghi, T. Gilpatrick, M. Molnar, A. Gershman, N. Sadowski, F. J. Sedlazeck, K. D. Hansen, J. T. Simpson, and W. Timp, “Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing,” Nature Methods, vol. 17, no. 12, pp. 1191–1199, Dec. 2020
J. T. Simpson, R. E. Workman, P. C. Zuzarte, M. David, L. J. Dursi, and W. Timp, “Detecting DNA cytosine methylation using nanopore sequencing,” Nature Methods, vol. 14, no. 4, pp. 407–410, Apr. 2017
P. M. Thielen*, S. Wohl*, T. Mehoke, S. Ramakrishnan, M. Kirsche, O. Falade-Nwulia, N. S. Trovão, A. Ernlund, C. Howser, N. Sadowski, C. P. Morris, M. Hopkins, M. Schwartz, Y. Fan, V. Gniazdowski, J. Lessler, L. Sauer, M. C. Schatz, J. D. Evans, S. C. Ray, W. Timp, and H. H. Mostafa, “Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore–Washington metropolitan area,” JCI Insight, vol. 6, no. 6, Mar. 2021.
R. E. Workman*, A. D. Tang*, P. S. Tang*, M. Jain*, J. R. Tyson*, R. Razaghi*, P. C. Zuzarte, T. Gilpatrick, A. Payne, J. Quick, N. Sadowski, N. Holmes, J. G. de Jesus, K. L. Jones, C. M. Soulette, T. P. Snutch, N. Loman, B. Paten, M. Loose, J. T. Simpson, H. E. Olsen, A. N. Brooks, M. Akeson§, and W. Timp, “Nanopore native RNA sequencing of a human poly(A) transcriptome,” Nature Methods, pp. 1–9, Nov. 2019
T. Gilpatrick, I. Lee, J. E. Graham, E. Raimondeau, R. Bowen, A. Heron, B. Downs, S. Sukumar, F. J. Sedlazeck, and W. Timp, “Targeted nanopore sequencing with Cas9-guided adapter ligation,” Nature Biotechnology, Feb. 2020