Tian-Li Wang, PhD

Highlights

Languages

English

Gender

Female

Johns Hopkins Affiliations:

Johns Hopkins School of Medicine Faculty

About Tian-Li Wang

Professional Titles

Director of the Molecular Genetics Laboratory of Female Reproductive Cancer

Primary Academic Title

Professor of Pathology

Background

Dr. Tian-Li Wang is the Professor of Pathology, Oncology, and Gynecology and Obstetrics at the Johns Hopkins University School of Medicine. She is the Director of the Molecular Genetics Laboratory of Female Reproductive Cancer and a senior member at the Breast and Ovarian Cancer Program at the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins. She has been a leader in several program projects/grants including a multi-institutional Consortium Award from DoD-CDMRP (total budget 12 M). Currently, she is an Executive Co-Director of the Ovarian Cancer SPORE funded by NCI.

Dr. Wang received a Ph.D. degree from The Johns Hopkins University School of Medicine. She went on to a post-doc training in the retina neural circuity research area at the University of Pennsylvania and subsequently, completed her training in Cancer Genetics at the Howard Hughes Medical Institution at Johns Hopkins.

She has performed pioneering research on genomic characterization of ovarian cancer including using a Digital Karyotyping technology developed by her team. Her team has studied treatment-resistant mechanisms of ovarian cancer and has developed small molecule compounds targeting the PBX1 oncogenic pathway.

Centers and Institutes

Adolescent Health, Center for
Global Health Promotion Research Program
Ovarian Cancer Specialized Program of Research Excellence (SPORE)
Sidney Kimmel Comprehensive Cancer Center

Additional Academic Titles

Professor of Gynecology and Obstetrics, Professor of Oncology

Contact for Research Inquiries

CRBII, Rm 306
1550 Orleans Street,
Baltimore, MD 21231

Research Interests

Cancer genetics/genomics, chemoresistance in ovarian cancer, DNA damage repair, female reproductive cancer, NOTCH/PBX1 signaling

Lab Website

Molecular Genetics Laboratory of Female Reproductive Cancer - Lab Website

Gynecologic Research Laboratory - Lab Website

Ovarain Cancer SPORE Program - Lab Website

Research Summary

Ovarian carcinoma is one of the most deadly neoplastic diseases among women; however, little is known about the molecular etiology of this disease. Dr. Wang’s research focuses on understanding genetic and epigenetic bases of this devastating disease and applying the knowledge onto develop new cancer diagnostics, prevention, and therapeutics. Dr. Wang has developed approaches to elucidate the genetic alterations at both DNA-sequence and copy-number levels, including high-throughput mutational detection and digital karyotyping, a technology that permits the identification of copy number alterations in cancer on a genome-wide scale with high resolution. Using both strategies, she has performed a comprehensive analysis of gynecologic malignancies and her team has identified several novel oncogenes and tumor suppressor genes in ovarian cancers. Her team is currently focusing on revealing treatment-resistant mechanisms of ovarian cancer, including interrogating heterogeneity in the tumor microenvironment.

Google Scholar

https://scholar.google.com/scholar?hl=en&q=tian-li+wang&btnG=&as_sdt=1%2C21&as_sdtp=

Patents

Small molecule compounds targeting pbx1 transcriptional complex, US20180118688A1
Small molecule compounds targeting pbx1 transcriptional complex,
Small molecule compounds targeting pbx1 transcriptional complex
WO2016172437A2
P13K pathway mutations in cancer, US9580750B2
Digital Karyotyping,
Digital Karyotyping
US7704687B2
Detection of cancer by measuring genomic copy number and strand length in cell-free dna,
Detection of cancer by measuring genomic copy number and strand length in cell-free DNA
WO2009051842A2