
Theodoros Karantanos, MD, PhD
Hematology Oncology
- Johns Hopkins School of Medicine Faculty
About Theodoros Karantanos
Primary Academic Title
Assistant Professor of Oncology
Background
Dr. Karantanos graduated from the School of Health Sciences at the University of Athens, Greece and received a Ph.D. in cancer biology. As a post-doctoral research fellow at MD Anderson Cancer Center/University of Texas, he studied signal transduction in cancer and developed expertise in mouse modeling and targeted therapies. He completed his internal medicine residency and Chief residency training at Boston University and his medical oncology fellowship training at Johns Hopkins. His clinical research focused on sex-related differences in the genomic profile and outcomes of MPN and MDS/MPN patients. As a research fellow he studied malignant hematopoiesis and his work led to the identification of CCRL2, as an inducer of MDS/sAML cells growth and a mediator of azacitidine resistance.
Research Interests
Molecular biology of MDS and AML
Lab Website
Research Summary
My research focuses on the dissection of growth signaling regulation in MDS and MDS/MPN and mechanisms implicated in the progression of chronic myeloid diseases to AML. My work incorporates gene editing by CRISPR-Cas9, signal transduction analysis, progenitor assays, drug screens and MDS/AML xenograft models.
Our lab studies the molecular biology of growth signaling regulation in MDS and MDS/MPN and investigates novel therapies that can effectively target these pathways using in vitro and in vivo models.
Selected Publications
Karantanos T, Chaturvedi S, Braunstein EM, Spivak JL, Resar L, Karanika S, Williams D, Rogers O, Gocke C, Moliterno AR. Sex determines the presentation and outcomes in MPN and is related to sex-specific differences in the mutational burden. Blood Adv. 2020 Jun 23;4(12):2567-2576
Karantanos T, Gondek LP, Varadhan R. Moliterno AR, Dezern AE, Jones RJ, Jain T. Gender-related differences in the outcomes and genomic landscape of patients with MDS/MPN. Br J Haematol. 2021 Jun;193(6):1142-1150
Karantanos T, Teodorescu P, Arvanitis M, Perkins B, Jain T, DeZern AE, Dalton WB, Christodoulou I, Paun BC, Varadhan R, Esteb C, Rajkhowa T, Bonifant C, Gondek LP, Levis MJ, Yegnasubramanian S, Ghiaur G, Jones RJ. CCRL2 affects the sensitivity of myelodysplastic syndrome and secondary acute myeloid leukemia cells to azacitidine. Haematologica. 2022 Dec 15
Karantanos T, Teodorescu P, Perkins B, Christodoulou I, Esteb C, Varadhan R, Helmenstine E, Rajkhowa T, Paun BC, Bonifant C, Dalton WB, Gondek LP, Moliterno AR, Levis MJ, Ghiaur G, Jones RJ. The role of the atypical chemokine receptor CCRL2 in myelodysplastic syndrome and secondary acute myeloid leukemia. Sci Adv. 2022 Feb 18;8(7):eabl8952
Karantanos T, Tsai HL, Gondek LP, DeZern AE, Ghiaur G, Dalton WB, Gojo I, Prince GT, Webster J, Ambinder A, Smith BD, Levis MJ, Varadhan R, Jones RJ, Jain T. Genomic landscape of myelodysplastic/myeloproliferative neoplasm can predict response to hypomethylating agent therapy. Leuk Lymphoma. 2022 Aug;63(8):1942-1948
Honors
- K08 Clinical Scientist Research Career Development Award, NIH/NHLBI, 4/24/23
- Passano Award, Passano Foundation, 3/1/23
- Clinician Scientist Award, Johns Hopkins University, 1/1/23
- MacMillan Pathway to Independence Program, Sidney Kimmel Cancer Center, 7/1/22
- Research Training Award for Fellows, American Society of Hematology, 7/1/21
- Physician Scientist Johns Hopkins Training Program Grant, 1/1/21
- T32 Training Program in Hematology, Johns Hopkins University, 7/1/19
- Prostate Cancer Foundation (PCF) Young Investigator Award, 5/1/13
- Hellenic Society of Medical Oncology Young Investigator Award, 7/1/12
Memberships
- American Society of Hematology
- American Society of Clinical Oncology
- American Association for Cancer Research
- American Society of Transplantation and Cellular Therapy
Professional Activities
- Leukemia Service Attending
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Oncology, 2022Boston Medical Center
Residency, Internal Medicine, 2017National and Kapodistrian University of Athens
Graduate School, Cancer Biology, PhD, 2016National and Kapodistrian University of Athens
Medical Education, MD, 2011Board Certifications
Medical Oncology
American Board of Internal Medicine, 2020Internal Medicine
American Board of Internal Medicine, 2017Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)