Suman Paul, MBBS, PhD

Primary Academic Title

Assistant Professor of Oncology

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Recent News Articles and Media Coverage

• Researchers Create Modified Antibodies to Target RAS and p53 in Cancer, Cancer.gov (April 2, 2021)
• Mutant Gene-Targeted Immunotherapy Approach Developed, Brookhaven National Laboratory (April 2, 2021)
• Advances in Off-the-Shelf Immunotherapy: Expert Discussion, Oncology Times (October 5, 2021)
• First soluble TCR therapy opens ‘new universe’ of cancer targets. Nature Biotechnology (March 24, 2022)
• Leukemia Lymphoma Society award recipient, Leukemia & Lymphoma Society
• Johns Hopkins Investigators Develop Novel Treatment for T-cell Leukemias and Lymphoma, HopkinsMedicine.org (April 2, 2024)

Research Interests

Bispecific Antibody Therapy, CAR T Cell Therapy, T-cell Acute Lymphoblastic Leukemias, T-cell Lymphomas

Lab Website

Suman Paul Laboratory - Lab Website

• At the Suman Paul laboratory, we are focused on developing new antibodies and cell therapies for cancer treatment. Our team of researchers are dedicated to identifying novel targets, mechanisms for cancer therapy and developing innovative solutions to improve patient outcomes. We work closely with basic science researchers and clinicians to accelerate the translation of our discoveries into clinical practice.

PubMed

https://www.ncbi.nlm.nih.gov/myncbi/suman.paul.1/bibliography/public/

Selected Publications

• Paul S, Pearlman A, Douglass J, Mog BJ, Hsiue EH, Hwang MS, DiNapoli S, Konig MF, Brown P, Wright KM, Gabelli SB, Li Y, Ghiaur G, Pardoll DM, Papadopoulos N, Bettegowda C, Kinzler KW, Zhou S, Vogelstein B. TCR beta chain-directed bispecific antibodies for the treatment of T-cell cancer. Science Translational Medicine. 2021 March. PMID: 33649188
• Paul S, Tsai HL, Fuchs EJ, Luznik L, Bolaños-Meade J, Swinnen LJ, Shanbhag S, Wagner-Johnston N, Varadhan R, Ambinder RF, Jones RJ, Gladstone DE. Allogeneic Haploidentical Blood or Marrow Transplantation with Post-Transplant Cyclophosphamide in Chronic Lymphocytic Leukemia. Biology of Blood and Marrow Transplantation. 2019 Nov. PMID: 31730920
• Paul S, Zahurak M, Fuchs EJ, Luznik L, Bolaños-Meade J, Swinnen LJ, Shanbhag S, Wagner-Johnston N, Varadhan R, Ambinder RF, Jones RJ, Gladstone DE. Non-Myeloablative Allogeneic Transplantation with Post-Transplant Cyclophosphamide after Immune Checkpoint Inhibition for Classic Hodgkin Lymphoma: a Retrospective Cohort Study. Biology of Blood and Marrow Transplantation. 2020 June. PMID: 32592857
• Paul S, Konig M, Pardoll D, Bettegowda C, Papadopoulos N, Wright KM, Gabelli SB, Ho Mitchell, Elsas AV, Zhou S. Cancer therapy with antibodies. Nature Reviews Cancer 2024 May. PMID 38740967
• Nichakawade T, Ge J, Mog B, Pearlman A, Hwang M, DiNapoli S, Wyhs N, Marcou N, Glavaris S, Konig M, Watson E, Sterling C, Wagner-Johnston N, Rozati S, Ambinder R, Pardoll DM, Papadopoulos N, Bettegowda C, Kinzler K, Zhou S, Sur S, Vogelstein B, Paul S. Cancer therapy with antibodies. Nature 2024 April. PMID: 38538786

Patents

• TRBC1 and TRBC2 bispecific antibodies for targeting T-cell cancers, 63/150,232
• Methods and materials for treating t cell cancers, 63/119,753,

Honors

• American Society of Hematology (ASH) Scholar Award, 1/1/22
• SITC-Amgen Cancer Immunotherapy in Hematologic Malignancies Fellowship, Society for Immunotherapy of Cancer, 7/1/20
• The MacMillan Pathway to Independence Program, Johns Hopkins School of Medicine, 7/1/20
• NIH T32 grant, 5T32CA009071-38, National Cancer Institute, 7/1/18
• Alpha Omega Alpha Honor Medical Society Resident Inductee, 2/2/17
• Young Investigator Award, American College of Physicians, 10/10/16
• Emma L. Bockman Award for outstanding scholastic achievement, Uniformed Services University, 3/4/13
• Val-G-Hemming Pre-doctoral Fellowship, Henry Jackson Foundation, 7/1/12
• Young Investigator Award, American Association of Immunologists, 2/2/12
• Pre-doctoral Fellowship, American Heart Association, 7/1/10

Memberships

• Society for Immunotherapy of Cancer
• American Society of Clinical Oncology
• American Society of Hematology