Stuart Campbell Ray, MD
Infectious Diseases
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Stuart Campbell Ray
Professional Titles
- Vice Chair of Medicine for Data Integrity and Analytics, Department of Medicine
- Research Subcouncil Co-Chair of the JHM AI & Data Trust
Primary Academic Title
Professor of Medicine
Background
Stuart C. Ray, MD, FACP, FIDSA serves as Vice Chair of Medicine for Data Integrity and Analytics, and is a Professor in the Division of Infectious Diseases within the Department of Medicine, with a secondary appointment in Oncology. He is a virologist and clinical investigator in the Center for Viral Hepatitis Research in the Division of Infectious Diseases. He is a faculty member of the Janeway Firm of the Osler Medical Service, and the graduate programs in Immunology, Pharmacology, and Health Sciences Informatics. He is a member of the Johns Hopkins Medicine AI & Data Trust Council, and Co-Chair of the Research Subcouncil.
Dr. Ray received his M.D. from Vanderbilt University School of Medicine in 1990. After an internship and residency at Johns Hopkins Hospital, he continued there as an Assistant Chief of Service and fellow in Infectious Diseases. During his fellowship, he studied the immunology and sequence variation of HIV in the laboratory of Dr. Robert Bollinger. During that time, he developed an interest in RNA virus evolution in productive collaborations with Dr. Robert Siliciano.
In 1997 Dr. Ray joined the Johns Hopkins faculty, and under the mentorship of Dr. David Thomas shifted his primary research focus to hepatitis C virus (HCV). His laboratory work has focused on the evolution of HCV during acute and chronic infection, developing and applying computational and molecular biology tools to underlying mechanisms including stochastic variation, immune selection, and viral fitness. He continues to care for patients with HIV, HCV, and other infectious diseases.
Centers and Institutes
- Computational Medicine, Institute for
- Infectious Diseases Center for Viral ImmunoPathogenesis
- Institute for Data Intensive Engineering and Science
- NanoBio Technology, Institute for
- Sidney Kimmel Comprehensive Cancer Center
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Additional Academic Titles
Professor of Oncology
Contact for Research Inquiries
Center for Viral ImmunoPathogenesis
855 N. Wolfe St, Rangos bldg
Baltimore, MD 21205
Research Interests
Computational biology, Hepatitis C immunology, Hepatitis C virology, HIV pathogenesis, NanoDiagnostics, Viral Evolution
Research Summary
Dr. Ray's research focuses on viral evolution and human immunology, with a long-term interest in hepatitis C virus (HCV) sequence evolution and persistence. HCV affects more than millions of people in the United States and many millions of people worldwide. Current treatment is highly effective but most infected people are unaware of their infection, and an America newly contracts HCV every 30 seconds. Thus, Dr. Ray remains dedicated to enhanced screening, access to care, harm reduction, and rational vaccine development for HCV.
Google Scholar
Selected Publications
Bailey JR, Wasilewski LN, Snider AE, El-Diwany R, Osburn WO, Keck Z, Foung SK, Ray SC. Naturally selected hepatitis C virus polymorphisms confer broad neutralizing antibody resistance. The Journal of Clinical Investigation. 2015; 125(1):437-47
Newman RM, Lamers SL, Weiner B, Ray SC, Colgrove RC, Diaz F, Jing L, Wang K, Saif S, Young S, Henn M, Laeyendecker O, Tobian AA, Cohen JI, Koelle DM, Quinn TC, Knipe DM. Genome Sequencing and Analysis of Geographically Diverse Clinical Isolates of Herpes Simplex Virus 2. Journal of Virology. 2015; 89(16):8219-32
Ogega CO, Skinner NE, Blair PW, Park HS, Littlefield K, Ganesan A, Dhakal S, Ladiwala P, Antar AA, Ray SC, Betenbaugh MJ, Pekosz A, Klein SL, Manabe YC, Cox AL, Bailey JR. Durable SARS-CoV-2 B cell immunity after mild or severe disease. J Clin Invest. 2021 Apr 1;131(7). doi: 10.1172/JCI145516. PubMed PMID: 33571162; PubMed Central PMCID: PMC8011891
Thielen PM, Wohl S, Mehoke T, Ramakrishnan S, Kirsche M, Falade-Nwulia O, Trovão NS, Ernlund A, Howser C, Sadowski N, Morris CP, Hopkins M, Schwartz M, Fan Y, Gniazdowski V, Lessler J, Sauer L, Schatz MC, Evans JD, Ray SC, Timp W, Mostafa HH. Genomic diversity of SARS-CoV-2 during early introduction into the Baltimore-Washington metropolitan area. JCI Insight. 2021 Mar 22;6(6). doi: 10.1172/jci.insight.144350. PubMed PMID: 33749660; PubMed Central PMCID: PMC8026189
Woldemeskel BA, Kwaa AK, Garliss CC, Laeyendecker O, Ray SC, Blankson JN. Healthy donor T cell responses to common cold coronaviruses and SARS-CoV-2. J Clin Invest. 2020 Dec 1;130(12):6631-6638. doi: 10.1172/JCI143120. PubMed PMID: 32966269; PubMed Central PMCID: PMC7685719
Courses & Syllabi
Scientific Foundations of Medicine: Immunology, Johns Hopkins University School of Medicine, ME.250.631
Patents
- Use of consensus sequence as vaccine antigen to enhance recognition of virulent viral variants, USPTO 8168771, 1 May 2012
- Synthetic hepatitis C genome and methods of making and use, USPTO 9512183, 6 Dec 2016
- Aggregation-assisted separation of plasma from whole blood, USPTO 10788480, 29 Sept 2020
- Antiviral proteins and their uses in therapeutic methods, USPTO 11180758, 23 Nov 2021
- Hepatitis C virus gene sequences and methods of use thereof, USPTO 11596679, 7 March 2023
- Nucleoside-modified mRNA-lipid nanoparticle lineage vaccine for hepatitis C virus, USPTO 11660332,30 May 2023
Honors
- Elected Fellow, American College of Physicians, 1/1/16
- Elected Member, Interurban Clinical Club, 1/1/16
- Professors' Award for Excellence in Teaching, Basic and Clinical Sciences, Johns Hopkins University, 1/1/12
- Elected member and JHU Institutional Representative, American Society of Clinical Investigation, 1/1/09
- Elected Fellow, Infectious Diseases Society of America, 1/1/08
Graduate Program Affiliations
Memberships
- American Association for the Study of Liver Disease
- American College of Physicians
- American Society for Microbiology
- American Society for Virology
- American Society of Clinical Investigation
- European Association for the Study of the Liver
- Infectious Diseases Society of America
- International Society for Computational Biology
- Society for Molecular Biology and Evolution
- Society of Industrial and Applied Mathematics
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Infectious Diseases, 1997Johns Hopkins University School of Medicine
Fellowship, Infectious Diseases, 1994Johns Hopkins University School of Medicine
Residency, Internal Medicine, 1993Vanderbilt University School of Medicine
Medical Education, MD, 1990Board Certifications
Infectious Disease
American Board of Internal Medicine, 2014Internal Medicine
American Board of Internal Medicine, 1993Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)