Stuart Grossman, MD

Professional Titles

• Co-Director, Brain Cancer Research Program, Sidney Kimmel Cancer Center

Primary Academic Title

Professor of Oncology

Background

Centers and Institutes

Sidney Kimmel Comprehensive Cancer Center

Clinical Trial Keywords

cancer pain; brain tumors

Research Interests

brain cancer, cancer pain

PubMed

http://www.ncbi.nlm.nih.gov/pubmed/?term=grossman+stuart+a

Selected Publications

• Blakeley, J.O.; Grossman, S.A. Management of pineal region tumors. Current Treatment Options in Oncology. 2006 Nov;7(6):505-516.
  
  Chu, L.C.; Eberhart, C.G.; Grossman, S.A.; Herman, J.G. Epigenetic silencing of multiple genes in primary CNS lymphoma. Int J Cancer. 2006 Nov 15;119(10):2487-2491.
  
  Gerber, D.E.; Grossman, S.A. Does decompressive surgery improve outcome in patients with metastatic epidural spinal-cord compression? Nature clinical practiceNeurology. 2006 Jan;2(1):10-11.
  
  Gerber, D.E.; Grossman, S.A.; Streiff, M.B. Management of venous thromboembolism in patients with primary and metastatic brain tumors. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2006 Mar 10;24(8):1310-1318.
  
  Grossman, S.A.; Carson, K.A.; Batchelor, T.T.; Lesser, G.; Mikkelsen, T.; Alavi, J.B.; Phuphanich, S.; Hammour, T.; Fisher, J.D.; Supko, J.G. The effect of enzyme-inducing antiseizure drugs on the pharmacokinetics and tolerability of procarbazine hydrochloride. Clinical Cancer Res:An Official Journal of the American Association for Cancer Res. 2006 Sep 1;12(17):5174-5181.
  
  Mathew, B.S.; Carson, K.A.; Grossman, S.A. Initial response to glucocorticoids. Cancer. 2006 Jan 15;106(2):383-387.
  
  Weaver, K.D.; Grossman, S.A.; Herman, J.G. Methylated tumor-specific DNA as a plasma biomarker in patients with glioma. Cancer investigation. 2006 Feb;24(1):35-40.
  
  Carson, K.A.; Grossman, S.A.; Fisher, J.D.; Shaw, E.G. Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium phase I and II clinical trials. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Jun 20;25(18):2601-2606.
  
  Gerber, D.E., T. Chan, S. A. Grossman, L. Kleinberg Intracranial Hemorrhage during GliaSite RTS manipulation in an anticoagulated patient. Journal Radiotherapy in Practice. 2007;6 (1):53-57.
  
  Gerber, D.E.; Grossman, S.A.; Batchelor, T.; Ye, X. Calculated versus measured creatinine clearance for dosing methotrexate in the treatment of primary central nervous system lymphoma. Cancer chemotherapy and pharmacology. 2007 May;59(6):817-823.
  
  Gerber, D.E.; Grossman, S.A.; Zeltzman, M.; Parisi, M.A.; Kleinberg, L. The impact of thrombocytopenia from temozolomide and radiation in newly diagnosed adults with high-grade gliomas. Neuro-oncology. 2007 Jan;9(1):47-52.
  
  Gerber, D.E.; Segal, J.B.; Salhotra, A.; Olivi, A.; Grossman, S.A.; Streiff, M.B. Venous thromboembolism occurs infrequently in meningioma patients receiving combined modality prophylaxis. Cancer. 2007 Jan 15;109(2):300-305.
  
  Kelloff, G.J.; Sullivan, D.C.; Baker, H.; Clarke, L.P.; Nordstrom, R.; Tatum, J.L.; Dorfman, G.S.; Jacobs, P.; Berg, C.D.; Pomper, M.G.; Birrer, M.J.; Tempero, M.; Higley, H.R.; Petty, B.G.; Sigman, C.C.; Maley, C.; Sharma, P.; Wax, A.; Ginsberg, G.G.; Dannenberg, A.J.; Hawk, E.T.; Messing, E.M.; Grossman, H.B.; Harisinghani, M.; Bigio, I.J.; Griebel, D.; Henson, D.E.; Fabian, C.J.; Ferrara, K.; Fantini, S.; Schnall, M.D.; Zujewski, J.A.; Hayes, W.; Klein, E.A.; DeMarzo, A.; Ocak, I.; Ketterling, J.A.; Tempany, C.; Shtern, F.; Parnes, H.L.; Gomez, J.; Srivastava, S.; Szabo, E.; Lam, S.; Seibel, E.J.; Massion, P.; McLennan, G.; Cleary, K.; Suh, R.; Burt, R.W.; Pfeiffer, R.M.; Hoffman, J.M.; Roy, H.K.; Wang, T.; Limburg, P.J.; El-Deiry, W.S.; Papadimitrakopoulou, V.; Hittelman, W.N.; MacAulay, C.; Veltri, R.W.; Solomon, D.; Jeronimo, J.; Richards-Kortum, R.; Johnson, K.A.; Viner, J.L.; Stratton, S.P.; Rajadhyaksha, M.; Dhawan, A. Workshop on imaging science development for cancer prevention and preemption. Cancer Biomark. 2007;3(1):1-33.
  
  Mikkelsen, T.; Lush, R.; Grossman, S.A.; Carson, K.A.; Fisher, J.D.; Alavi, J.B.; Rosenfeld, S. Phase II clinical and pharmacologic study of radiation therapy and carboxyamido-triazole (CAI) in adults with newly diagnosed glioblastoma multiforme. Investigational new drugs. 2007 Jun;25(3):259-263.
  
  Nabors, L.B.; Mikkelsen, T.; Rosenfeld, S.S.; Hochberg, F.; Akella, N.S.; Fisher, J.D.; Cloud, G.A.; Zhang, Y.; Carson, K.; Wittemer, S.M.; Colevas, A.D.; Grossman, S.A. Phase I and correlative biology study of cilengitide in patients with recurrent malignant glioma. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 May 1;25(13):1651-1657.
  
  Peng, T.; Blakeley, J.; Cingolani, E.; Griffiths, E.; Grossman, S.A. Herpes simplex encephalitis in a patient with recurrent pituitary adenoma receiving radiation therapy. American journal of clinical oncology. 2007 Dec;30(6):664-665.
  
  Weingart, J.; Grossman, S.A.; Carson, K.A.; Fisher, J.D.; Delaney, S.M.; Rosenblum, M.L.; Olivi, A.; Judy, K.; Tatter, S.B.; Dolan, M.E. Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007 Feb 1;25(4):399-404.
  
  Blakeley, J.; Grossman, S. Anaplastic oligodendroglioma. Current treatment options in neurology. 2008 Jul;10(4):295-307.
  
  Brem, S.S.; Bierman, P.J.; Black, P.; Brem, H.; Chamberlain, M.C.; Chiocca, E.A.; DeAngelis, L.M.; Fenstermaker, R.A.; Friedman, A.; Gilbert, M.R.; Glass, J.; Grossman, S.A.; Heimberger, A.B.; Junck, L.; Linette, G.P.; Loeffler, J.J.; Maor, M.H.; Moots, P.; Mrugala, M.; Nabors, L.B.; Newton, H.B.; Olivi, A.; Portnow, J.; Prados, M.; Raizer, J.J.; Shrieve, D.C.; Sills, A.K., Jr. Central nervous system cancers. Journal of the National Comprehensive Cancer Network : JNCCN. 2008 May;6(5):456-504.
  
  Chen, H.; Shah, A.S.; Girgis, R.E.; Grossman, S.A. Transmission of glioblastoma multiforme after bilateral lung transplantation. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008 Jul 1;26(19):3284-3285.
  
  Easter, J.S.; Grossman, S.A.; Woodruff, M.M.; Rosen, C.L. When the rules do not work: head injury without loss of consciousness. The Journal of emergency medicine. 2008 Jul;35(1):77-80.
  
  Gerstner, E.R.; Carson, K.A.; Grossman, S.A.; Batchelor, T.T. Long-term outcome in PCNSL patients treated with high-dose methotrexate and deferred radiation. Neurology. 2008 Jan 29;70(5):401-402.
  
  Grossman, S.A.; Carson, K.A.; Phuphanich, S.; Batchelor, T.; Peereboom, D.; Nabors, L.B.; Lesser, G.; Hausheer, F.; Supko, J.G.; New Approaches to Brain Tumor Therapy, C.N.S.C. Phase I and pharmacokinetic study of karenitecin in patients with recurrent malignant gliomas. Neuro-oncology. 2008 Aug;10(4):608-616.
  
  Grossman, S.A.; Olson, J.; Batchelor, T.; Peereboom, D.; Lesser, G.; Desideri, S.; Ye, X.; Hammour, T.; Supko, J.G.; New Approaches to Brain Tumor Therapy, C.N.S.C. Effect of phenytoin on celecoxib pharmacokinetics in patients with glioblastoma. Neuro-oncology. 2008 Apr;10(2):190-198.
  
  Blakeley, J.O.; Olson, J.; Grossman, S.A.; He, X.; Weingart, J.; Supko, J.G.; New Approaches to Brain Tumor Therapy, C. Effect of blood brain barrier permeability in recurrent high grade gliomas on the intratumoral pharmacokinetics of methotrexate: a microdialysis study. Journal of neuro-oncology. 2009 Jan;91(1):51-58.
  
  De Jesus, A.; Grossman, S.A.; Paun, O. Cytomegalovirus associated colonic pseudotumor: a consequence of iatrogenic immunosuppression in a patient with primary brain tumor receiving radiation and temozolomide. Journal of neuro-oncology. 2009 Sep;94(3):445-448.
  
  Grossman, S.A.; Ye, X.; Chamberlain, M.; Mikkelsen, T.; Batchelor, T.; Desideri, S.; Piantadosi, S.; Fisher, J.; Fine, H.A. Talampanel with standard radiation and temozolomide in patients with newly diagnosed glioblastoma: a multicenter phase II trial. J Clin Oncol. 2009 Sep 1;27(25):4155-4161.
  
  Holdhoff, M.; Supko, J.G.; Gallia, G.L.; Hann, C.L.; Bonekamp, D.; Ye, X.; Cao, B.; Olivi, A.; Grossman, S.A. Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J Neurooncol. 2009 Sep 19;97(2):241-250.
  
  McGirt, M.J.; Than, K.D.; Weingart, J.D.; Chaichana, K.L.; Attenello, F.J.; Olivi, A.; Laterra, J.; Kleinberg, L.R.; Grossman, S.A.; Brem, H.; Quinones-Hinojosa, A. Gliadel (BCNU) wafer plus concomitant temozolomide therapy after primary resection of glioblastoma multiforme. Journal of neurosurgery. 2009 Mar;110(3):583-588.
  
  Grossman, R.; Mukherjee, D.; Chang, D.C.; Purtell, M.; Lim, M.; Brem, H.; Quinones-Hinojosa, A. Predictors of Inpatient Death and Complications among Postoperative Elderly Patients with Metastatic Brain Tumors. Annals of surgical oncology. 2010 (Journal Article).
  
  Grossman, S.A.; Ye, X.; Piantadosi, S.; Desideri, S.; Nabors, L.B.; Rosenfeld, M.; Fisher, J.; Consortium, N.C. Survival of patients with newly diagnosed glioblastoma treated with radiation and temozolomide in research studies in the United States. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010;16(8):2443-2449.
  
  Holdhoff, M.; Supko, J.G.; Gallia, G.L.; Hann, C.L.; Bonekamp, D.; Ye, X.; Cao, B.; Olivi, A.; Grossman, S.A. Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J Neurooncol. 2010 Apr;97(2):241-245.
  
  Peereboom, D.M.; Supko, J.G.; Carson, K.A.; Batchelor, T.; Phuphanich, S.; Lesser, G.; Mikkelsen, T.; Fisher, J.; Desideri, S.; He, X.; Grossman, S.A.; New Approaches to Brain Tumor Therapy, C. A phase I/II trial and pharmacokinetic study of ixabepilone in adult patients with recurrent high-grade gliomas. Journal of neuro-oncology. 2010;100(2):261-268.
  
  Phuphanich, S.; Supko, J.G.; Carson, K.A.; Grossman, S.A.; Burt Nabors, L.; Mikkelsen, T.; Lesser, G.; Rosenfeld, S.; Desideri, S.; Olson, J.J. Phase 1 clinical trial of bortezomib in adults with recurrent malignant glioma. Journal of neuro-oncology. 2010;100(1):95-103.
  
  Rosenfeld, M.R.; Chamberlain, M.C.; Grossman, S.A.; Peereboom, D.M.; Lesser, G.J.; Batchelor, T.T.; Desideri, S.; Salazar, A.M.; Ye, X. A multi-institution phase II study of poly-ICLC and radiotherapy with concurrent and adjuvant temozolomide in adults with newly diagnosed glioblastoma. Neuro-oncology. 2010;12(10):1071-1077.
  
  Zhou, J.; Tryggestad, E.; Wen, Z.; Lal, B.; Zhou, T.; Grossman, R.; Wang, S.; Yan, K.; Fu, D.X.; Ford, E.; Tyler, B.; Blakeley, J.; Laterra, J.; van Zijl, P.C. Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nat Med. 2011 Jan;17(1):130-134.