Stephen J. Meltzer, MD
Gastroenterology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Stephen J. Meltzer
Primary Academic Title
Professor of Medicine
Background
Dr. Stephen J. Meltzer is a Professor of Medicine and Oncology at Johns Hopkins University, Division of Gastroenterology. He is the Director of GI Early Detection Biomarkers Laboratory and a member of the Johns Hopkins Kimmel Cancer Center. His research interests are Gastrointestinal cancer and precancer biomarker discover, development and validation; genomics, epigenomics and bioinformatics, early detection of cancer, outcomes research in cancer and precancer, risk stratification prediction in cancer and precancer, Barrett's esophagus, inflammatory bowel disease-associated cancer, liver cancer and gastric cancer. After receiving degree in Medicine at the State University of New York Medical School, Dr. Meltzer interned at Tulane University in New Orleans and University of Texas Medical Branch in Galveston, TX. He completed his fellowship training program in the University of Colorado and the Lenox Hill Hospital. He was an Assistant Professor in UCLA, Center for Health Science in 1987. Prior to joining the faculty at Johns Hopkins in 2006, he was Professor of Medicine and Pharmacology, Founder and Head of Aero digestive Cancer/Biomarker Program in School of Medicine, University of Maryland at Baltimore. He is an Associate Editor of Cancer Research and a member of the editorial board of Esophageal. He has published 152 original scientific papers in high-impact scientific journals. He also has 43 chapters, review articles, editorials, or letters to the editor; 1 book; and 139 abstracts to his name. He has given a plethora of invited lectures around the world, all involving his principal field of esophageal and gastrointestinal cancer research. He has been the recipient of numerous prestigious national and international awards, including the Robert and Sally D. Funderburg Award in Gastric Cancer Biology and membership in the American Society for Clinical Investigation.
Special Interests: Gastrointestinal cancer and precancer biomarker discover, development and validation; genomics, epigenomics and bioinformatics, early detection of cancer, outcomes research in cancer and precancer, risk stratification prediction in cancer and precancer. Barrett's esophagus, inflammatory bowel disease-associated cancer, liver cancer, gastric cancer
Centers and Institutes
Recent News Articles and Media Coverage
Johns Hopkins Developing New Test for Esophageal Cancer, Inside Tract (Spring 2019)
Trouble on Line-1, Inside Tract (Winter 2016)
Additional Academic Titles
Professor of Oncology
Research Interests
Molecular pathophysiology and translational research in Barrett’s esophagus-associated neoplastic progression
Lab Website
GI Biomarkers Laboratory - Lab Website
- The GI Biomarkers Laboratory studies gastrointestinal cancer and pre-cancer biogenesis and biomarkers. The lab is led by Dr. Stephen Meltzer, who is known for his research in the molecular pathobiology of gastrointestinal malignancy and premalignancy. Research in the lab has led to several groundbreaking genomic, epigenomic and bioinformatic studies of esophageal and colonic neoplasms, shifting the gastrointestinal research paradaigm toward genome-wide approaches.
Selected Publications
Generation and multiomic profiling of a TP53/CDKN2A double-knockout gastroesophageal junction organoid model
HUA ZHAO, YULAN CHENG, ANDREW KALRA, KE MA, YUEYUAN ZHENG, BENJAMIN ZIMAN, CAITLIN TRESSLER, KRISTINE GLUNDE, EUN JI SHIN, SAOWANEE NGAMRUENGPHONG, MOUEN KHASHAB, VIKESH SINGH, ROBERT A. ANDERS, SIMRAN JIT, NICOLAS WYHS, WEI CHEN, XU LI, DE-CHEN LIN, AND STEPHEN J. MELTZER
SCIENCE TRANSLATIONAL MEDICINE, 30 Nov 2022 Vol 14, Issue 673
DOI: 10.1126/scitranslmed.abq6146
Hypermethylated APC DNA in plasma and prognosis of patients with esophageal adenocarcinoma K Kawakami, J Brabender, RV Lord, S Groshen, BD Greenwald, ... Journal of the National Cancer Institute 92 (22), 1805-1811
Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas KT Wilson, S Fu, KS Ramanujam, SJ Meltzer Cancer Research 58 (14), 2929-2934
Microsatellite instability in the insulin-like growth factor II receptor gene in gastrointestinal tumours. RF Souza, R Appel, J Yin, S Wang, KN Smolinski, JM Abraham, TT Zou, ... Nature genetics 14 (3), 255
PTEN1 is frequently mutated in primary endometrial carcinomas D Kong, A Suzuki, TT Zou, A Sakurada, LW Kemp, S Wakatsuki, ...Nature genetics 17 (2), 143-144
Lectures & Presentations
American Cancer Society Clinical Research Professor
The Harry & Betty Myerberg/Thomas R. Hendrix Professor of Gastroenterology
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Northwell Health Lenox Hill Hospital
Fellowship, Gastroenterology, 1985University of Colorado Anschutz
Fellowship, Gastroenterology, 1984University of Texas Medical Branch Galveston
Residency, Internal Medicine, 1982University at Buffalo Niagara Medical Center
Medical Education, MD, 1979Board Certifications
Gastroenterology
American Board of Internal Medicine, 1985Internal Medicine
American Board of Internal Medicine, 1982Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)