Scott Krummey, MD, PhD
Pathology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Scott Krummey
Primary Academic Title
Assistant Professor of Pathology
Background
Scott Krummey earned his B.A. in Molecular Biology at Colgate University. He earned M.D. and Ph.D. degrees from Emory University School of Medicine. He completed residency in Clinical Pathology and fellowship in Histocompatibility & Immunogenetics at Emory University. He is an Associate Director of the Immunogenetics Laboratory at Johns Hopkins.
Dr. Krummey’s research interests are in understanding cellular mechanisms of alloimmunity, with a focus on how cosignaling receptors and antigen recognition pathways can be exploited to restrain the lymphocytes that cause graft rejection. His laboratory studies mouse and human graft-specific CD8+ T cells, CD4+ T cells, and B cells using including MHC tetramers, transgenic mouse models, and high-dimensional flow cytometry.
Selected Publications
Krummey SM, Cheeseman JA, Conger JA, Jang PS, Mehta AK, Kirk AD, Larsen CP, Ford ML. High CTLA-4 Expression on Th17 Memory Cells Results in Increased Sensitivity to CTLA-4 Coinhibition and Resistance to Belatacept. Am J Transplant. 2014 Mar;14(3): 607-14. PMCID: 4124942
Krummey SM, Hartigan CR, Liu D, Ford ML. CD28-Dependent CTLA-4 Expression Fine Tunes the Activation of Human Th17 Cells. iScience. 2020. Feb 23(4): 100912 PMID: 32203908
Krummey SM, Martinez RJ, Andargachew R, Liu D, Wagener M, Kohlmeier JE, Evavold BD, Larsen CP, Ford ML. Low Affinity Memory CD8+ T Cells Mediate Robust Heterologous Immunity. J Immunol. 2016 Mar 196(6): 2838-46. PMID: 26864034
Krummey SM, Morris AB, Jacobs J, McGuire DJ, Ando S, Tong KP, Zhang W, Robertson J, Guasch SA, Araki K, Larsen CP, Evavold BD, Kissick HT, Ford ML. CD45RB Status Defines TCR Priming Affinity and CD8+ T Cell Memory Persistence. Cell Reports. 2020 Feb 30(5):1282-1291. PMID: 320203448
Liu D, Krummey SM, Badell IR, Wagener M, Schneeweis LA, Suchard SA, Nadler SG, Ford ML. 2B4 (CD244) Induced by Selective CD28 Blockade Functionally Regulates Allograft-Specific CD8+ T Cell Responses. J Exp Med. 2014 Feb 10;211(2): 297-311. PMCID: 3920565
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Emory University School of Medicine
Fellowship, Histocompatibility and Immunogenetics, 2020Emory University School of Medicine
Residency, Pathology Laboratory Medicine, 2019Emory University School of Medicine
Medical Education, MD, 2016Emory University School of Medicine
Graduate School, PhD, 2014Board Certifications
Clinical Pathology
American Board of Pathology, 2019Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)