Rachel D. Green, PhD
- Johns Hopkins School of Medicine Faculty
Languages
- English
Gender
FemaleAbout Rachel D. Green
Professional Titles
- Bloomberg Distinguished Professor of Molecular Biology and Genetics
- Daniel Nathans Director of the Department of Molecular Biology and Genetics and Professor in Molecular Biology and Genetics
- HHMI Investigator
Primary Academic Title
Professor of Molecular Biology and Genetics
Background
Dr. Rachel Green is a Bloomberg Distinguished Professor of Molecular Biology and Genetics at the Johns Hopkins University School of Medicine. She holds the Daniel Nathans Directorship of the Department of Molecular Biology and Genetics and Professorship in Molecular Biology and Genetics.
Dr. Green’s work has been supported by the Howard Hughes Medical Institute since 2000. Her laboratory focuses on examining the molecular mechanisms of translation and their implications for gene regulation in bacteria, yeast and higher eukaryotic systems. Recent work has focused on mechanistic aspects of ribosome-mediated quality control and with the intersection between ribosome function and cellular fate signaling pathways. These studies have direct relevance to cellular homeostasis in health and disease.
Dr. Green joined the Johns Hopkins faculty as an assistant professor in 1998. She earned her Ph.D. in biological chemistry at Harvard University before completing a postdoctoral fellowship at the University of California, Santa Cruz. She also holds a B.S. with honors in chemistry from the University of Michigan.
Dr. Green has published scores of journal articles and garnered a number of awards and honors, including being named the Johns Hopkins School of Medicine’s Teacher of the Year in 2005.
She serves on the SAB at Moderna and consults for numerous other biotech industries.
Dr. Green was elected to the National Academy of Sciences in 2012.
Centers and Institutes
Recent News Articles and Media Coverage
Additional Academic Titles
Professor of Oncology
Research Interests
and Translational Control in Health and Disease, Molecular Mechanisms of Protein Synthesis, Ribosome-Mediated Quality Control
Lab Website
Green Lab - Lab Website
The ribosome is a complex molecular machine that translates the genetic code into functional polypeptides. Our work focuses on understanding how the ribosome functions at a molecular level and how changes in its activity lead to mRNA quality control and the induction of cellular stress responses. Work in the Green lab ranges widely in scope, from detailed mechanistic questions in ribosome rescue to surveying global changes in gene expression and dissecting the complex interplay of mammalian signaling pathways. We use a wide range of genetic, genomic, and biochemical approaches to explore these questions in bacteria, yeast, and increasingly in mammalian systems. Much of our ongoing work focuses on the importance of ribosome collisions in activating signaling pathways such as the integrated stress response (ISR) and various MAP kinase cascades.
Honors
- Member, National Academy of Medicine, 10/16/17
- Teacher of the Year, Johns Hopkins University School of Medicine, 1/1/05
- Investigator, Howard Hughes Medical Institute, 1/1/00
- Assistant Investigator Award, Howard Hughes Medical Institute, 1/1/00
- David and Lucile Packard Fellowship Award, 1/1/00
- Searle Scholarship Award, 1/1/99
- Award for Young Scientists, RPI/RNA, 1/1/99
- Postdoctoral Fellowship, American Cancer Society (California Division), 1/1/96
- Burroughs Wellcome Career Award, 1/1/96
- Damon Runyon Walter Winchell Postdoctoral Fellowship, 1/1/93
- Predoctoral Fellowship, National Science Foundation, 1/1/87
Graduate Program Affiliations
Biochemistry, Cellular and Molecular Biology Graduate Program
Program in Molecular Biophysics
Additional Training
University of California, Santa Cruz, Santa Cruz, CA, 1998, Biology