Philip Chun Ying Wong, PhD
Highlights
Languages
- English
Gender
MaleJohns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Philip Chun Ying Wong
Primary Academic Title
Professor of Pathology
Background
Dr. Philip Wong is a professor of pathology and neuroscience at the Johns Hopkins University School of Medicine. His research focuses on understanding the molecular mechanisms of neurodegenerative disorders, such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) - frontotemporal dementia (FTD).
Dr. Wong’s team takes a molecular/cellular approach, including transgenic, gene targeting, and RNAi strategies in mice, to develop models that facilitate their understanding of pathogenesis of AD and ALS-FTD as well as the identification and validation of novel targets for mechanism-based therapeutics.
He received his undergraduate degree in biochemistry and his Ph.D. in biochemistry and molecular biology from the University of Western Ontario in Canada. He completed a postdoctoral fellowship in cellular and molecular biology at the Johns Hopkins University School of Medicine in the Department of Biological Chemistry. Dr. Wong joined the Johns Hopkins faculty in 1994.
Dr. Wong is a member of the Society of Neuroscience and a member of the editorial board for Molecular Neurodegeneration. Dr. Wong’s work has been recognized with the 2004 Zenith Fellow’s Award from the Alzheimer’s Association and the 2007 MetLife Foundation Award for Medical Research in AD.
Additional Academic Titles
Professor of Neuroscience
Contact for Research Inquiries
720 Rutland Avenue
558 Ross
Baltimore, MD 21205-2109
Research Interests
ALS-FTD and Inclusion Body Myositis, Alzheimer's disease
Lab Website
Philip Wong Lab - Lab Website
The focus of the Wong's lab is to clarify the main problem underlying Alzhemer's disease and related dementia using state-of-the-art technologies with the goal of developing appropriate therapies for these disorders.
Research Summary
The overarching themes of the Wong lab focus on the biology and pathobiology of an RNA splicing factor termed TDP-43 (TAR DNA/RNA binding protein 43kDa) that regulate the inclusion of cryptic exons, the loss of which underlies the pathogenic mechanism of several human age-related degenerative diseases, including Alzheimer’s Disease Related Dementia (ADRD), Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia (FTD) as well as Inclusion Body Myositis (IBM).
Selected Publications
Britson KA, Ling JP, Braunstein KE, Montagne J, Kastenschmidt J, Tsao W, Russel1 KA, Reed N, Wagner KR, Ostrow LW, Corse AM, Mammen AL, Villalta A, Larman HB, Wong PC* and Lloyd TE*: Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis. Science Translational Medicine 14, eabi9196, January 19, 2022
Chiang, P., Ling, J., Jeong, Y.H., Price, D.L., Aja, S.M. & Wong, P.C. (2010). Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism. PNAS, 107(37), 16320-16324. PMC2941284
Donde A, Sun M, Ling JP, Braunstein KE, Pang B, Wen X, Cheng X, Chen L and Wong PC (2019). Splicing repression is a major function of TDP 43 in motor neurons. Acta Neuropathologica July 22, (doi.org/10.1007/s00401-019-02042-8). PMC6802294
Li, T., Braunstein K.E., Zhang, J., Lau, A., Sibener, L., Deeble, C., Wong, P.C. (2016). The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nature Communications, 7, 12082. PMC4932197
Ling, J.P., Pletnikova, O., Troncoso, J.C. & Wong, P.C. (2015). TDP-43 repression of nonconserved cryptic exons is compromised in ALS-FTD. Science, 349(6248), 650-655. PMC4825810
Courses & Syllabi
Pathobiology for Graduate Students: Neuropathology, Johns Hopkins Medicine, ME300.715
Honors
- Zenith Fellows Award, Alzheimer's Association, 1/1/04
- Teacher of the Year Award (Pathobiology Graduate Program, Department of Pathology, 1/1/04
- CART Fund for Alzheimer's disease research, Rotary CART, 1/1/02
- Cal Ripken/Lou Gehrig Fund for Neuromuscular Research, Johns Hopkins School of Medicine, 1/1/97
- Leadership and Excellence in Alzheimer's Disease (LEAD) Award, National Institute of Aging, 1/1/94
- Postdoctoral Fellowship, Muscular Dystrophy Association, 1/1/90
Graduate Program Affiliations
Cellular and Molecular Medicine Program
Neuroscience Graduate Program
Pathobiology
Memberships
- Society for Neuroscience
Professional Activities
- Alzheimer's Association, 1/1/99
- American Federation for Aging Research, 1/1/99
- Canadian Institute of Health, Research grant review panel, 1/1/06
- Cellular & Molecular Medicine, Admissions Committee, 1/1/02
- CMM, Policy Committee, 1/1/02
- Department of Pathology, Ad hoc committee for Faculty Promotion, 1/1/01
- Division of Neuropathology, Chair, 1/1/04
- Division of Neuropathology, Research Advisory Committee, 1/1/05
- Drugs Discovery Today: Disease Models, Section Editor, 1/1/03
- Graduate Pathobiology Curriculum Committee, 1/1/02
- Neuro-Signals, Editorial board, 1/1/01
- Pathology Department, Molecular Pathology Seminar Series" Committee, 1/1/97
- Robert Packard Center for ALS Research at JHMI, Operating Committee, 1/1/03
- Rodent Research, Advisory Board, 1/1/01
Additional Training
Johns Hopkins University, Baltimore, MD, 1993, Cellular/Molecular Biology