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Mohammad Rezaee

Mohammad Rezaee, PhD

Johns Hopkins Affiliations:
  • Johns Hopkins School of Medicine Faculty

Languages

  • English

Gender

Male

About Mohammad Rezaee

Primary Academic Title

Assistant Professor of Radiation Oncology and Molecular Radiation Sciences

Background

Dr. Mohammad Rezaee is an assistant professor of radiation oncology and molecular radiation sciences at the Johns Hopkins University School of Medicine. His area of expertise is in medical physics and radiation biophysics.

Upon completion of undergraduate studies in radiological sciences and MSc in medical physics, Dr. Rezaee worked in life sciences industry for 8 years and implemented several industrial projects to validate and modernize various processes in hospitals, biological and pharmaceutical centers. He then completed his PhD study in Radiation Sciences and Biomedical Imaging in the University of Sherbrook in Canada. After graduate studies and postdoctoral training, Dr. Rezaee joined the Medical Physics Residency Program at Princess Margaret Cancer Centre in the University of Toronto and received his clinical certificate in therapeutic physics from Canadian College of Physicists in Medicine (CCPM). He had developed the expertise in the field of radiation sciences including physics and biophysics with therapeutic and diagnostic applications during his academic study, postdoctoral and residency training programs.

After completion of his residency, he joined the University Health Network and Acumyn Inc (TECHNA). Dr. Rezaee led Aqua Radiology project, a software platform that automates and unifies all quality assurance activities of medical imaging devices across various medical centers. In 2017, Dr. Rezaee joined the Department of Radiation Oncology and Molecular Radiation Sciences in the Johns Hopkins University as a clinical physicist.  He has been lead physicist in the brachytherapy program. He is also a member of the Radiation Core and physics advisor of advanced preclinical radiation research at the Sidney Kimmel Comprehensive Cancer Center in the Johns Hopkins University. He has invented an orthovoltage x-ray FLASH irradiation system for preclinical laboratory research on small animals and cell cultures. Dr. Rezaee has developed FLASH radiation research program at the Department of Radiation Oncology and Molecular Radiation Sciences at the Johns Hopkins University School of Medicine.

Additional Academic Titles

Assistant Professor of Oncology

Research Interests

Radiation Physics and Biophysics, Medical Physics

Research Summary

My research interest is radiation physics, biophysics, and their exploitation to improve the efficacy of radiation therapy using different methods including FLASH radiotherapy, high-LET charged particles, radiosensitizers, and Auger-electron emitting radionuclides. One of my major focuses is to develop FLASH radiotherapy for preclinical studies, and elucidation of biophysical and biological mechanisms, and its translation into clinical practices. My research program has three main fields of research:

Physics and Biophysics – researches in this field includes dosimetry of ultrahigh dose-rate (FLASH) kV x-ray irradiation system and FLASH proton beam, development of Monte-Carlo dose engine for preclinical radiation research and physicochemical/chemical processes in high-LET charged particles and FLASH radiotherapy, and development of molecular dosimeters.

Biology – researches in this field includes investigation of early biological events (e.g. DNA damage formation) induced by high-LET charged particles and FLASH irradiation, normal and tumor cell responses to these radiations, and their combination with chemotherapeutic agents,

Clinical Translation – Researches in this field focus on the translation of FLASH radiotherapy into clinic for both superficial and deep-seated tumors using kV x-rays and MeV proton FLASH beams, development of treatment planning system, and quality assurance of ultrahigh dose-rate irradiation systems.

Selected Publications

Patents

An ultra-high (FLASH) dose rate x-ray cabinet system for pre-clinical laboratory radiation research, US2021/055294

Additional Training

  • Postdoctoral Fellowship, Radiation Biophysics, University of Sherbrooke, Sherbrooke, QC, Canada (2013)

Expertise

Education

University of Sherbrooke - Quebec

Ph.D., 2013

Mashhad University of Medical Sciences

M.Sc., 2001

Shahid Beheshti University of Medical Sciences - Tehran

B.Sc., 1997