Ming-Tseh Lin, MD, PhD
Pathology
Highlights
Johns Hopkins Affiliations:
- Johns Hopkins School of Medicine Faculty
About Ming-Tseh Lin
Professional Titles
- Associate Director, Molecular Diagnostics Laboratory, Department of Pathology
Primary Academic Title
Associate Professor of Pathology
Background
Dr. Ming-Tseh Lin is an associate professor of pathology at the Johns Hopkins University School of Medicine and serves as the associate director of the Department of Pathology’s Molecular Diagnostics Laboratory.
A molecular pathologist, Dr. Lin is an expert in the development and validation of new assays, including the clinical application of next-generation sequencing (NGS) platforms.
Because he initially practiced as a hematologist and bone-marrow transplant specialist, Dr. Lin has a unique perspective on molecular diagnostics.
Dr. Lin earned his medical and doctoral degrees at National Taiwan University Medical School and Hospital (Taipei), where he trained in internal medicine and hematology. He completed pathology residencies at The Johns Hopkins Hospital and Albany Medical College, as well as two pathology fellowships at Hopkins.
Dr. Lin has published more than 100 academic journal articles.
Contact for Research Inquiries
1812 Ashland Avenue
Suite 200
Baltimore, MD 21205
Research Interests
Cancer biomarkers, Molecular diagnosis of solid tumors, Next-generation sequencing (NGS) platforms
Lab Website
Chung-Ming Tse
- The Tse Lab does basic and translational research on the function and regulation of sodium/hydrogen exchange-2 isoform, and molecular biology of nucleoside transporters.
Research Summary
Dr. Lin is an expert in the development and validation of new assays, including the clinical application of next-generation sequencing (NGS) platforms.
His current research aims to identify cancer biomarkers.
In addition, investigators in the CLIA-certified Molecular Diagnostics Laboratory led by Dr. Lin have validated the NGS platform for mutation detection of formalin-fixed, paraffin-embedded neoplastic tissues.
Dr. Lin has previously studied the association between single- nucleotide polymorphisms and the outcomes of patients who underwent hematopoietic cell transplantation.
Selected Publications
Lin MT, Mosier SL, Thiess M, Beierl KF, Debeljak M, Tseng LH, Chen G, Yegnasubramanian S, Ho H, Cope L, Wheelan SJ, Gocke CD, Eshleman JR. Clinical validation of KRAS, BRAF, and EGFR mutation detection using next-generation sequencing. Am J Clin Pathol. 2014;141:856-66.
Lin MT, Storer B, Martin PJ, Tseng LH, Gooley T, Chen PJ, Hansen JA. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med. 2003; 349:2201-10.
Belchis DA, Tseng LH, Gniadek T, Haley L, Lokhandwala p, Illei P, Gocke CD, Forde P, Brahmer J, Askin FB, Eshleman JR, Lin MT. Heterogeneity of resistance mutations detectable by next-generation sequencing in TKI-treated lung adenocarcinoma. Oncotarget. 2016;7:45237-48
Haley L, Tseng LH, Zheng G, Dudley J, Anderson DA, Azad NS, Gocke CD, Eshleman JR, Lin MT. Performance characteristics of next-generation sequencing in clinical mutation detection of colorectal cancers. Mod Pathol. 2015;28:1390-9.
Zheng G, Tseng LH, Chen G, Haley L, Illei P, Gocke CD, Eshleman JR, Lin MT. Clinical detection and categorization of uncommon and concomitant mutations involving BRAF. BMC Cancer. 2015;15:779.
Lectures & Presentations
Molecular Biology Advances in Myeloid Neoplasms, Invited speaker, Forth Dain-Hopkins Forum, Dain, China, Hangzhou, China, 6/30/18
Memberships
- Association of Molecular Pathology; United States and Canadian Academy of Pathology; College of American Pathologists
Locations
- The Johns Hopkins Hospital
- 1800 Orleans Street, Baltimore, MD 21287
- phone: 410-955-5000
- fax: 410-955-5001
Expertise
Education
Johns Hopkins University School of Medicine
Fellowship, Pathology, 2010Johns Hopkins University School of Medicine
Residency, Pathology, 2009Johns Hopkins University School of Medicine
Fellowship, Pathology, 2008Albany Medical Center
Residency, Pathology, 2006National Taiwan University Hospital
Graduate School, PhD, 1996National Taiwan University Hospital
Residency, Internal Medicine, 1991National Taiwan University Hospital
Fellowship, Hematology, 1991National Taiwan University School of Medicine
Medical Education, MD, 1984Board Certifications
Molecular Genetic Pathology
American Board of Pathology, 2011Anatomic Pathology
American Board of Pathology, 2009Insurance
- Aetna
- CareFirst
- Cigna
- First Health
- Geisinger Health Plan
- HealthSmart/Accel
- Humana
- Johns Hopkins Health Plans
- MultiPlan
- Pennsylvania's Preferred Health Networks (PPHN)
- Point Comfort Underwriters
- Private Healthcare Systems (PHCS)
- UnitedHealthcare
- Veteran Affairs Community Care Network (Optum-VACCN)