Search
Loading Complete
Mei Wan

Mei Wan, PhD

Highlights

Languages

  • English

Gender

Female

Johns Hopkins Affiliations:

  • Johns Hopkins School of Medicine Faculty

About Mei Wan

Professional Titles

  • Frank J. Frassica Professor of Orthopaedic Surgery

Primary Academic Title

Professor of Orthopaedic Surgery

Background

Dr. Mei Wan is the Frank J. Frassica Professor of Orthopaedic Surgery. Her research has primarily focused on the mechanisms underlying the senescence of bone and bone marrow cells and the role of these senescent cells in skeletal disorders. Additionally, she has a keen interest in unraveling the impact of bone-derived signals on the aging processes of the central nervous system and vascular system.

Dr. Mei Wan has served as a Ph.D. program faculty for multiple JHU graduate programs, including BME, CMM, and Pathobiology.

Dr. Wan earned her Ph.D. degree from Hebei Medical University. She completed her postgraduate training at the University of Alabama at Birmingham. Prior to joining Johns Hopkins, Dr. Wan was an Associate Professor of Pathology at the University of Alabama at Birmingham.

Dr. Mei Wan has served on the editorial board for Bone Research and as a Reviewing Editor for eLife. Furthermore, she was previously a part of the editorial boards of The Journal of Bone and Mineral Research. In addition to her editorial roles, Dr. Wan has served as a standing member on the NIH SBSR study section.

Centers and Institutes

Musculoskeletal Center

Additional Academic Titles

Professor of Biomedical Engineering

Research Interests

Bone-Brain Crosstalk, Bone-Vascular Crosstalk, Cellular Senescence, Skeletal Disorders

Research Summary

Dr. Wan's research has primarily focused on the mechanisms underlying the senescence of bone and bone marrow cells and the role of these senescent cells in skeletal disorders. Additionally, she has a keen interest in unraveling the impact of bone-derived signals on the aging processes of the central nervous system and vascular system.

PubMed

https://www.ncbi.nlm.nih.gov/pubmed?term=wan%20mei

Selected Publications

  • Li C, Chai Y, Wang L, Gao B, Chen H, Zhou FQ, Luo X, Crane JL, Yu B, Cao X, and Wan M. Programmed Cell Senescence in Skeleton during Late Puberty. Nature Communications 2017; 8(1):1312. PMID:29101351

  • Liu G, Wang J, Wei Z, Fang CL, Shen K, Qian C, Qi C, Li T, Gao P, Wong PC, Lu H, Cao X, Wan M. Elevated PDGF-BB from bone impairs hippocampal vasculature by inducing PDGFRβ shedding from pericytes. Advanced Science 2023 Apr 27; e2206938.PMID: 37102631

  • Liu X, Chai Y, Liu G, Su W, Guo Q, Lv X, Gao P, Yu B, Ferbeyre G, Cao X, and Wan M. Osteoclasts Protect Bone Blood Vessels Against Senescence through the Angiogenin/Plexin-B2 Axis. Nature Communications 2021 ; 12:1706. PMCID: PMC7987975

  • Liu X, Gu Y, Kumar S, Amin S, Guo Q, Wang J, Fang C-L, Cao X, Wan M. Oxylipin-PPARγ-initiated adipocyte senescence propagates secondary senescence in the bone marrow. Cell Metabolism 2023 Apr 4;35(4):667-684.e6. PMCID: PMC10127143

  • Santhanam L, Liu G, Jandu S, Su W, Wodu BP, Savage W, Poe A, Liu X, Alexander LM, Cao X, Wan M. Skeleton-derived PDGF-BB mediates arterial stiffening. J Clin Invest. 2021; 130: e147116. PMCID: PMC8516464

Graduate Program Affiliations

  • BME Graduate Program

    CMM Graduate Program

    Pathobiology Graduate Program

Memberships

  • American Heart Association
  • American Society for Bone & Mineral Research
  • Endocrinology Society

Professional Activities

  • Bone Research, Editorial board, 7/1/12
  • eLife, Reviewing Editor, 7/1/21
  • The Journal of Bone and Mineral Research, Editorial board, 7/1/10 - 7/1/14